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Genetically determined resistance to infection with group B arboviruses. I. Distribution of the resistance gene among various mouse populations and characteristics of gene expression in vivo.

Darnell, M B; Koprowski, H; Lagerspetz, K.

J Infect Dis ; 129(3): 240-7, 1974 Mar.

Article En | MEDLINE | ID: mdl-4816304

Arbovirus Infections/immunology , Genes, Dominant , Mice, Inbred Strains/immunology , West Nile virus/immunology , Yellow fever virus/immunology , Alleles , Animals , Antigen-Antibody Reactions , Arbovirus Infections/genetics , Body Temperature Regulation , Complement System Proteins , Gene Frequency , Hemolysis , Homozygote , Immune Sera , Mice , Snakes , Venoms

Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice.

Darnell, M B; Koprowski, H.

J Infect Dis ; 129(3): 248-56, 1974 Mar.

Article En | MEDLINE | ID: mdl-4593241

Arbovirus Infections/immunology , Interferons , Mice, Inbred Strains/immunology , West Nile virus/immunology , Alleles , Animals , Arbovirus Infections/genetics , Cell Line , Cells, Cultured , Fluorescent Antibody Technique , Genes, Dominant , Hemolytic Plaque Technique , Homozygote , Mice , Viral Interference , Virus Replication , West Nile virus/growth & development

Physical properties of lactic dehydrogenase-elevating virus and its ribonucleic acid.

Darnell, M B; Plagemann, P G.

J Virol ; 10(5): 1082-5, 1972 Nov.

Article En | MEDLINE | ID: mdl-4344253

Infectious lactic dehydrogenase-elevating virus propagated in primary cultures of mouse peritoneal macrophages in the presence of (3)H-uridine and isolated by isopycnic centrifugation was found to have a density of 1.12 g/cm(3). Ribonucleic acid extracted from the virus by treatment with sodium dodecyl sulfate was single stranded with a sedimentation coefficient of approximately 48S.

RNA Viruses , RNA, Viral , Animals , Cells, Cultured , Centrifugation, Density Gradient , Centrifugation, Zonal , Dimethyl Sulfoxide , Hot Temperature , L Cells , L-Lactate Dehydrogenase , Macrophages , Mice , Nucleic Acid Denaturation , Peritoneum , RNA Viruses/analysis , RNA Viruses/growth & development , RNA, Viral/analysis , Retroviridae/analysis , Retroviridae/growth & development , Ribonucleases , Sodium Dodecyl Sulfate , Thymidine , Tritium , Uridine , Virus Cultivation