Effect of a simplified approach on recovery of children 6-59 months with wasting in Ethiopia: A noninferiority, cluster randomized controlled trial.

Worldwide, nearly 45 million children under the age of 5 years were affected by wasting in 2022. Ethiopia has been challenged by disasters increasing the caseload of children with wasting. This study aimed to determine the effect of a simplified approach on recovery of children with acute malnutrition as compared with the standard protocol. A cluster randomized, controlled, noninferiority trial was carried out in three regions of Ethiopia from December 4, 2021, to July 30, 2022. A total of 58 clusters (health posts) were randomized into intervention and control groups. Children with SAM in the intervention groups received two sachets of Ready-to-Use Therapeutic Food (RUTF), whereas children in the control groups received RUTF based on their body weight. Children with moderate acute malnutrition (MAM) received one sachet of RUTF and one sachet of Ready-to-Use Supplementary Food (RUSF) daily in the intervention and control groups, respectively. Per protocol (PP) and intention-to-treat analysis were used to compare recovery at a noninferiority margin of 15%. Data were collected from 55 health posts and 1032 children. In the PP analysis, the recovery rate of children with wasting among the simplified group (97.8%) was noninferior to the standard protocol group (97.7%), p = 0.399. The RUTF cost per treatment of child with SAM was 56.55 USD for the standard versus 42.78 USD for the simplified approach. The simplified approach is noninferior to the standard protocol in terms of recovery and has a lower cost of RUTF. Further study is recommended to assess the effectiveness of the simplified approach in emergency contexts.

Association of undernutrition and female infertility in East Africa: Finding from multi-country demographic and health surveys.

Introduction: Infertility is one of the public health problems affecting a significant number of women in the reproductive age group. Although female fertility is predominantly affected by gynecological and systemic diseases, lifestyle and nutritional factors also play an important role in secondary female infertility. Therefore, this study aimed to determine the pooled prevalence of secondary female infertility and its association with undernutrition using nationwide data from the Demographic and Health Surveys (DHS) of eastern African countries. Methods: The data of ten East African countries that comprise a weighted sample of 38,020 women data were accessed from measure DHS. Data processing and analysis were performed using STATA 15 software. A multilevel mixed-effect logistic regression model was fitted to examine the association between undernutrition and secondary infertility. Variables with a p-value < 0.05 were declared as significant factors associated with secondary infertility. Model comparison was done based on Akaike and Bayesian Information Criteria (AIC and BIC). To measure variation (random effects), Community-level variance with standard deviation and intra-cluster correlation coefficient (ICC) was used. Result: The proportion of women who have secondary infertility was 16.32% with 95%CI (15.96, 16.69), of which 26.94% were undernourished. This study found that being undernutrition (AOR = 1.74; 95%CI: 1.54-1.98) and overweight (AOR = 1.72; 95%CI: 1.62-1.86) were significantly associated with secondary infertility. Women aged >35 years (AOR = 3.47; 95%CI: 2.66-4.55), and rural residents (AOR = 1.16; 95%CI: 1.02-1.37) are other factors that are positively associated with secondary infertility. However, primary education (AOR = 0.87; 95%CI: 0.77-0.97) and richer wealth index (AOR = 0.84; 95%CI: 0.73-0.97) are protective factors for secondary infertility. Conclusion: This study indicated that there is a strong association between secondary infertility and undernutrition growing in Eastern Africa. Therefore, Health information dissemination and awareness creation on the impact of malnutrition on infertility should be given to the community and health care providers. Given this, it may lead to integrating nutrition counseling into both clinical settings for infertility management as well as national dietary guidelines for individuals of reproductive age.

Wasted Children and Wasted Time: A Challenge to Meeting the Nutrition Sustainable Development Goals with a High Economic Impact to Ethiopia.

Despite some progress in the reduction of the prevalence of child wasting in Ethiopia, the pace of progress has been slow. Despite millions of dollars being spent on the treatment of wasting every year, the increased frequency and magnitude of environmental and anthropogenic shocks has halted progress. This study aimed to present the trends of child wasting in Ethiopia and estimate the economic losses related to the slow progress towards meeting the sustainable development goal (SDG) targets. Weather shocks and civil unrest between 2015 and 2018 have halted progress. We used a "consequence model" to apply the coefficient risk-deficit on economic losses established in the global scientific literature to the Ethiopian health, demographic, and economic data to estimate economic losses related to child wasting. The impact of wasting on the national economy of Ethiopia is estimated to be 157.8-230.2 million United States dollars (USD), annually. The greatest contributor to the economic burden (43.5-63.5% of the burden depending on the discount rate) is the cost of supplies and human resources to treat wasting. To reach the 2030 SDGs, Ethiopia should increase its annual average reduction rate (AARR) in the numbers of child (<59 months) wasting from 0.1% to 5.4%. This will avert the wasting in 7.9 million cases and prevent additional economic costs of up to 803.7 million USD over the next decade. Increasing the reach of therapeutic interventions, but also identifying and implementing wasting prevention interventions, will be critical if the SDG targets are to be met and the opportunity of the children to thrive is not to be wasted.

Magnitude and predictors of undernutrition among children aged six to fifty nine months in Ethiopia: a cross sectional study.

BACKGROUND: Undernutrition among children continues to be a major public health problem in developing countries. In Ethiopian, 44% of under-five children were stunted while 29% and 10% were underweight and wasted respectively. However, predictors of undernutrition among children were not clearly known in the study area. Therefore, this study was aimed at determining prevalence and predictors of undernutrition among children aged 6-59 months in Hawassa town. METHOD: A community based cross-sectional study was conducted among 811 randomly selected children paired with their mothers/caregivers. Mothers/caregivers were interviewed to obtain social-demographic data and feeding practice. Anthropometric measurement was conducted to obtain anthropometric data. Data were entered into EPI info 6.04 and exported to SPSS 16 for analysis. Bivariate logistic regression analysis with Crude Odds Ratio at 95%CI was used to assess presence of association among variables. Multivariate logistic regression analysis with Adjusted Odds Ratio at 95%CI was conducted to determine predictors of undernutrition and association was declared significant at p ≤ 0.05. RESULT: The result of our study indicated that 39.3%, 15.8% and 6.3% of children were stunted, underweighted and wasted respectively. Multivariate logistic regression analysis identified male sex, mother older than 35 years, not fed on colostrum, cessation of breastfeeding before two years of age, frequency of complementary feeding per day and diarrheal morbidity in the last 12 months were statistically associated with stunting. Maternal education, family sizes and diarrheal morbidity in the past 12 months were significantly associated with underweight. Similarly, frequency of complementary feeding per day, age at cessation of breastfeeding, preceding birth interval and not fed on colostrum were associated to wasting. CONCLUSION: The prevalence of undernutrition; stunting, underweight and wasting, among under-five children is very common in the study area. Inappropriate feeding practice and diarrheal morbidity were found to be the main risk factors for undernutrition. Appropriate factor specific interventions including counseling on optimal child feeding practice and diarrhea prevention should be strengthened in the study area.