1.
Eur J Pediatr
; 167(9): 1021-3, 2008 Sep.
Article
En
| MEDLINE
| ID: mdl-18205013
This manuscript reports on two very low birth weight premature infants with respiratory distress, receiving parenteral nutrition and broad-spectrum antibiotics for about 3 weeks, who developed Candida albicans sepsis associated with fungal mycoses and endocarditis, despite treatment with Amphotericin B and Caspofungin. On days 40 and 47, respectively, antifungal therapy was modified to liposomal Amphotericin B combined with Fluconazole 6 mg/kg/day for 4 weeks, resulting in complete resolution of the mycetomas. Our observations suggest that the combination of liposomal Amphotericin B with Fluconazole is able to result in complete resolution of cardiac mycetomas in preterm infants.
Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Candidiasis/complications , Candidiasis/drug therapy , Endocarditis/complications , Fluconazole/therapeutic use , Mycetoma/complications , Mycetoma/drug therapy , Amphotericin B/administration & dosage , Antifungal Agents/administration & dosage , Drug Combinations , Endocarditis/drug therapy , Female , Fluconazole/administration & dosage , Humans , Infant, Newborn , Infant, Premature , Liposomes , Male