Effects of a cardiopulmonary telerehabilitation using functional exercises in individuals after COVID-19 hospital discharge: A randomized controlled trial.

INTRODUCTION: Individuals with severe coronavirus disease 2019 (COVID-19) may present respiratory and motor complications, requiring rehabilitation programs (RP) for long periods. However, access to cardiopulmonary rehabilitation is poor. Cardiopulmonary telerehabilitation is an alternative for cardiopulmonary dysfunction, improving functional capacity, dyspnea, and quality of life. Moreover, few clinical trials verified the effectiveness of telerehabilitation using functional exercise for post-COVID symptoms. Thus, the present study aimed to verify the effects of cardiopulmonary telerehabilitation using functional and accessible exercises in individuals after COVID-19 hospital discharge. METHODS: This blinded, randomized, and controlled clinical trial and included 67 adult individuals after COVID-19 hospital discharge. Participants were randomized into the groups of telerehabilitation (TG; n = 33) and control (CG; n = 34). TG underwent an individualized exercise program (functional and accessible exercises) supervised by a physical therapist (videoconference), and CG received guidance on general care and self-monitoring of vital signs (videoconference). The primary outcome was performance and physiological responses on the 6-minute step test (6MST). Secondary outcomes were performance on the 2-minute stationary walk test (2MSWT), 30-second chair stand test (30CST), and quality of life using the 36-Item Short Form Health Survey (SF-36) questionnaire physical functioning concept (PF). RESULTS: Functional capacity (6MST) improved by 28 ± 17 steps in TG and 15 ± 26 in CG (p = 0.04). For secondary outcomes, performance on 2MSWT increased by 39 ± 6 steps in TG and 10 ± 6 in CG (p = 0.00); 30CST by 3 ± 1 repetitions in TG and 1.5 ± 0.5 in CG (p = 0.05); and PF (SF-36) by 17 ± 4 points in TG and 12 ± 4 in CG (p = 0.00). Also, peak oxygen uptake VO2peak (6MST) improved by 3.8 ± 1 mL min-1 kg-1 in TG and 4.1 ± 1 in CG (p = 0.6), and heart rate demand (6MST) by 11 ± 37% in TG and -4 ± 19% in CG (p = 0.04). CONCLUSIONS: Cardiopulmonary telerehabilitation using functional exercises improved the exercise and functional capacity assessed using 6MST, 30CST, and 2MSWT and the quality of life of individuals after COVID-19 hospital discharge.

Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis.

BACKGROUND: Conventional measures to evaluate COPD may fail to capture systemic problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying these manifestations and assessing their association with clinical outcomes (ie, mortality, exacerbation and COPD hospital admission) is of increasing clinical importance. OBJECTIVE: To assess associations between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes in patients with stable COPD. METHODS: We systematically searched electronic databases (August 2018) and identified 61 studies, which were synthesised, including meta-analyses to estimate pooled HRs, following Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RESULTS: Shorter 6MWD and elevated heart rate, fibrinogen, CRP and WCC were associated with higher risk of mortality. Pooled HRs were 0.80 (95% CI 0.73 to 0.89) per 50 m longer 6MWD, 1.10 (95% CI 1.02 to 1.18) per 10 bpm higher heart rate, 3.13 (95% CI 2.14 to 4.57) per twofold increase in fibrinogen, 1.17 (95% CI 1.06 to 1.28) per twofold increase in CRP and 2.07 (95% CI 1.29 to 3.31) per twofold increase in WCC. Shorter 6MWD and elevated fibrinogen and CRP were associated with exacerbation, and shorter 6MWD, higher heart rate, CRP and IL-6 were associated with hospitalisation. Few studies examined associations with musculoskeletal measures. CONCLUSION: Findings suggest 6MWD, heart rate, CRP, fibrinogen and WCC are associated with clinical outcomes in patients with stable COPD. Use of musculoskeletal measures to assess outcomes in patients with COPD requires further investigation. TRIAL REGISTRATION NUMBER: CRD42016052075.

Reproducibility of inspiratory muscle endurance testing using PowerBreathe for COPD patients.

BACKGROUND: Assessing the strength and endurance of respiratory muscles is fundamental for characterizing respiratory muscle dysfunction. Although a variety of tests are used to evaluate respiratory muscle endurance, not all of them are applicable in clinical practice. Assessments can be made using a practical device called PowerBreathe®, but its reproducibility has not been tested in chronic obstructive pulmonary disease (COPD) patients. AIM: To verify the reproducibility of the inspiratory muscle endurance test using a manometer and PowerBreathe® in COPD patients. METHODS: A cross-sectional study was used. In total, 19 moderate-severe COPD patients, male and female, aged 50 to 80 years took part in the research. This evaluation consisted of 2 tests: an incremental test and a constant one held on the same day and repeated after 48 hr. The incremental test started with 10-cm H2 O, adding 10-cm H2 O every 2 min and taking 1 min of rest before increasing the load. The highest load that could be sustained for at least 1 min was considered the sustained maximum inspiratory pressure (SMIP) value. The constant test was performed at an intensity of 80% of the SMIP and the maximum time limit was 30 min. RESULTS: In the incremental test, there was a significant increase in the SMIP compared to the test-retest (61 ± 24/64.7 ± 23.8; p = .015); the value of the relative reproducibility was 0.96, the standard error of the absolute measurement was 4.7 (95% confidence interval 9.2), and the minimum detectable difference was 10.9. In the Bland-Altman analysis, the mean error was 4.2 (confidence interval -7.6 to 16.1). The constant test was not reproducible. CONCLUSION: It was observed that the incremental test was reproducible to evaluate inspiratory muscle endurance in COPD patients. Furthermore, 2 tests needed to be carried out due to the learning effect.

Assessment of exercise capacity among asthmatic and healthy adolescents.

OBJECTIVES: To compare the physical performance and responses obtained in the six-minute walking test (6MWT) and the six-minute step test (6MST) between asthmatic and healthy adolescents; and to investigate the relationship between the responses obtained in the tests and the body mass index (BMI), physical activity level and spirometric variables. METHODS: Nineteen asthmatic adolescents (AG) and 19 healthy adolescents (HG) of both sexes, aged between 11 and 15 years, were assessed by means of spirometry, the 6MWT and the 6MST, and their physical activity levels were quantified using the International Physical Activity Questionnaire (IPAQ). RESULTS: The AG had poorer physical performance, lower heart rate (HR) and greater lower-limb (LL) fatigue in the 6MST. In the 6MWT, the AG had positive correlations between walked distance (WD) and duration of intense activity, and between HR and BMI, whereas the HG had positive correlations between WD and HR and between WD and respiratory rate (RR). In the 6MST, the AG showed positive correlations between RR and maximum voluntary ventilation (MVV) and between duration of moderate activity and physical performance. The AG also showed negative correlations between physical performance in the 6MST and BMI, and between sensation of dyspnea and duration of walking. Also in the 6MST, the HG showed positive correlations between RR and MVV, and between BMI and LL fatigue (p < or = 0.05). CONCLUSION: The 6MST demonstrated differences in exercise capacity between the asthmatic and healthy individuals. Furthermore, the physical performance and responses obtained in the tests were correlated with the MVV, BMI and physical activity level.

Avaliação da capacidade de exercício em adolescentes asmáticos e saudáveis / Assessment of exercise capacity among asthmatic and healthy adolescents

OBJETIVOS: Comparar o desempenho físico e as respostas obtidas nos testes de caminhada de seis minutos (TC6) e do degrau de seis minutos (TD6) entre adolescentes asmáticos e saudáveis e correlacionar o índice de massa corpórea (IMC), o nível de atividade física e as variáveis espirométricas com as variáveis obtidas nos testes. MÉTODOS: Foram avaliados 19 adolescentes asmáticos (GA) e 19 saudáveis (GS), com idades entre 11 e 15 anos, de ambos os sexos, por meio da espirometria, do TC6 e do TD6 e foi quantificado o nível de atividade física pelo Questionário Internacional de Atividade Física (IPAQ). RESULTADOS: No TD6, observaram-se menores valores de desempenho físico (TD6-T) e frequência cardíaca (FC) e maiores valores de fadiga de membros inferiores (MMII) no GA. No TC6, houve correlação positiva no GA da distância percorrida (DP) com o tempo de atividade intensa e da FC com o IMC e, no GS, da DP com a FC e com a frequência respiratória (FR). No TD6, houve correlação positiva no GA da ventilação voluntária máxima (VVM) com a FR; do tempo de atividade moderada com o TD6-T; além de correlação negativa do TD6-T com o IMC e da dispneia com o tempo de caminhada; no GS, correlações positivas da VVM com a FR e da fadiga de MMII com IMC (p<0,05). CONCLUSÃO: O TD6 demonstrou diferença na capacidade para o exercício entre asmáticos e saudáveis. Além disso, o desempenho físico e as respostas obtidas nos testes correlacionaram-se com os valores de VVM, IMC e nível de atividade física.

OBJECTIVES: To compare the physical performance and responses obtained in the six-minute walking test (6MWT) and the six-minute step test (6MST) between asthmatic and healthy adolescents; and to investigate the relationship between the responses obtained in the tests and the body mass index (BMI), physical activity level and spirometric variables. METHODS: Nineteen asthmatic adolescents (AG) and 19 healthy adolescents (HG) of both sexes, aged between 11 and 15 years, were assessed by means of spirometry, the 6MWT and the 6MST, and their physical activity levels were quantified using the International Physical Activity Questionnaire (IPAQ). RESULTS: The AG had poorer physical performance, lower heart rate (HR) and greater lower-limb (LL) fatigue in the 6MST. In the 6MWT, the AG had positive correlations between walked distance (WD) and duration of intense activity, and between HR and BMI, whereas the HG had positive correlations between WD and HR and between WD and respiratory rate (RR). In the 6MST, the AG showed positive correlations between RR and maximum voluntary ventilation (MVV) and between duration of moderate activity and physical performance. The AG also showed negative correlations between physical performance in the 6MST and BMI, and between sensation of dyspnea and duration of walking. Also in the 6MST, the HG showed positive correlations between RR and MVV, and between BMI and LL fatigue (p<0.05). CONCLUSION: The 6MST demonstrated differences in exercise capacity between the asthmatic and healthy individuals. Furthermore, the physical performance and responses obtained in the tests were correlated with the MVV, BMI and physical activity level.