RESUMEN
Several antineuronal antibodies are associated with paraneoplastic cerebellar degeneration. Anti-Ri is one of these antibodies in some cases but it is more commonly associated with paraneoplastic opsoclonus myoclonus in the context of gynecological neoplasia. Anti-Ri autoantibodies are thought to be directed against onconeural antigens, NOVA-1 and NOVA-2, that are expressed by the tumor as well as by neurons. The results of the treatment of both syndromes have been disappointing, although aggressive multimodality immunosuppressive treatments have been used. There are few cases of anti-Ri paraneoplastic cerebellar degeneration and none has been pathologically studied. We report the pathological study of a patient who died from anti-Ri-positive paraneoplastic cerebellar degeneration associated with breast cancer only confirmed at autopsy.
Asunto(s)
Autoanticuerpos/análisis , Neoplasias de la Mama/inmunología , Degeneración Cerebelosa Paraneoplásica/inmunología , Anciano , Antígenos de Neoplasias/inmunología , Autoanticuerpos/sangre , Autoanticuerpos/líquido cefalorraquídeo , Autopsia , Neoplasias de la Mama/patología , Resultado Fatal , Femenino , Humanos , Degeneración Nerviosa/inmunología , Degeneración Nerviosa/patología , Neuronas/inmunología , Neuronas/patología , Degeneración Cerebelosa Paraneoplásica/patologíaRESUMEN
OBJECTIVES: To evaluate the clinical significance of Streptomyces isolates in different clinical samples. MATERIAL AND METHODS: Review of the records of all cases of Streptomyces isolated from any clinical sample at a tertiary Hospital, during a seven-year period. RESULTS: Streptomyces was isolated from 13 patients. All of them had underlying diseases. Only in one patient Streptomyces was considered to have a pathogenic role in the clinical picture. We report the third case of catheter-related infection caused by this microorganism. CONCLUSIONS: Streptomyces is usually isolated from patients with underlying diseases. Before considering them significative, Streptomyces isolates must be interpreted in the clinical context.
Asunto(s)
Bacteriemia/etiología , Cateterismo , Contaminación de Equipos , Infecciones por Bacterias Grampositivas/etiología , Infecciones por Bacterias Grampositivas/microbiología , Streptomyces/crecimiento & desarrollo , Streptomyces/aislamiento & purificación , Adulto , Humanos , MasculinoRESUMEN
Objetivo. Evaluar el significado clínico del aislamiento de Streptomyces en distintas muestras clínicas. Material y métodos. Se revisaron historias clínicas de los pacientes con aislamiento de Streptomyces en cualquier muestra clínica durante un período de siete años en un hospital terciario. Resultados. Se aisló Streptomyces en 13 pacientes. todos tenían enfermedades subyacentes. Sólo en un paciente Streptomyces fue considerado responsable del cuadro clínico. Se presenta el tercer caso de infección asociada a catéter por este microorganismo. Conclusiones. Streptomyces habitualmente se aísla en pacientes con patología subyacente. Su aislamiento debe interpretarse en el contexto clínico del paciente para considerarlo significativo
OBJECTIVES: To evaluate the clinical significance of Streptomyces isolates in different clinical samples. MATERIAL AND METHODS: Review of the records of all cases of Streptomyces isolated from any clinical sample at a tertiary Hospital, during a seven-year period. RESULTS: Streptomyces was isolated from 13 patients. All of them had underlying diseases. Only in one patient Streptomyces was considered to have a pathogenic role in the clinical picture. We report the third case of catheter-related infection caused by this microorganism. CONCLUSIONS: Streptomyces is usually isolated from patients with underlying diseases. Before considering them significative, Streptomyces isolates must be interpreted in the clinical context
