Quantitative assessment of anterior chamber parameters in pigmentary glaucoma using slit-lamp optical coherence tomography.

PURPOSE: To quantitatively assess the parameters of anterior chamber and angle dimensions by slit-lamp optical coherence tomography (SL-OCT) in eyes with pigmentary glaucoma (PG). METHODS: A total of 18 eyes of 11 patients with PG and 18 eyes of 11 healthy volunteers were included in the study. Anterior chamber depth (ACD), anterior chamber volume (ACV), spur distance (internal horizontal anterior chamber diameter), central corneal thickness (CCT), angle opening distance at 500 microm from the scleral spur (AOD 500), and trabecular iris space area at 500 microm from the scleral spur (TISA 500) parameters were detected by SL-OCT. The differences of anterior chamber parameters between patients with PG and the control group were analyzed by Mann-Whitney U test. RESULTS: Mean ACD and ACV were measured as 3.28 +/- 0.38 mm and 191.6 +/- 39.7 mm3 respectively in the PG group. Mean AOD 500 and TISA 500 were 0.88 +/- 0.47 mm and 0.29 +/- 0.15 mm2 at the nasal angle and 1.14 +/- 0.67 mm and 0.41 +/- 0.23 mm2 at the temporal angle, respectively. Nasal and temporal angles were 49.83 +/- 11.1 degrees and 53.83 +/- 10.46 degrees. In eyes with PG, the midperipheral iris configuration was found to be considerably concave in 15 eyes (83.3%). Except CCT and spur distance, all anterior chamber dimension and angle parameters detected by SL-OCT were found to be significantly higher in the eyes with PG (Mann-Whitney U test, p < 0.05). CONCLUSIONS. SL-OCT provided highly quantitative data on the parameters of anterior chamber and angle dimensions in PG. The evaluation of the anterior segment anatomy using SL-OCT revealed increased anterior chamber dimensions and posterior bowing of the iris consistent with the increase in angle parameters in patients with PG.

A case of sterile endophthalmitis after repeated intravitreal bevacizumab injection.

PURPOSE: The aim of this study was to describe a case of sterile endophthalmitis after repeated intravitreal bevacizumab injections for the treatment of choroidal neovascularization secondary to angioid streaks. METHODS: This study was done as a case report. RESULTS: A 57-year-old man who received a third injection of intravitreal bevacizumab for the treatment of choroidal neovascularization owing to angioid streaks developed sterile endophthalmitis. The patient's condition improved after hourly topical steroid and antibiotic drops without a sequele. CONCLUSIONS: The intravitreal injection of bevacizumab has the potential for the development of sterile endophthalmitis. The patients should be warned against this possible adverse reaction, especially after repeated injections.