RESUMEN
OBJECTIVE: The purpose of this study was to evaluate the content and quality of internet information resources in Turkey about temporomandibular disorders (TMDs). METHODS: In July 2020, the keywords "jaw joint disease" (çene eklemi rahatsizligi) and "jaw joint pain" (çene eklemi agrisi) were searched on Google, Bing, YAHOO!, and Yandex. The first 20 websites were listed for 2 keywords on the 4 search engines. Scientific articles, product websites, repetitive sites, advertisements, and irrelevant websites were excluded from the list. The remaining 77 websites were assessed using the Quality Criteria for Consumer Health Information (DISCERN), Global Quality Score (GQS) and Journal of American Medical Association (JAMA) benchmarks. The topics related to TMDs that were thought to be important in informing the patient were determined and the Temporomandibular Disorder Content Score (TMDCS) was calculated to evaluate whether these contents were available on the website. RESULTS: The sources of the 77 websites included dentists in private practice (6.5%, n=5), hospitals/polyclinics (32.5%, n=25), universities (6.5%, n=5), and others (54.5%, n=42). The total DISCERN scores of all websites included were poor (average score 26.96). Mean scores of JAMA, GQS, and TMDCS were 1.75, 2.31, and 8.4, respectively. CONCLUSION: The quality and reliability of the information on the websites related to TMDs are poor. Clinicians should be aware that patients may have access to unreliable or incomplete information. There is a need for improvement on websites about TMDs, especially by professionals through imparting more comprehensive and reliable information.
RESUMEN
Cancer, which causes the deaths of millions of people, is an important public health problem worldwide. Despite significant advances in the diagnosis and treatment of cancer, survival rates are still insufficient in progressive cancers. Today, one of the most important reasons for not being able to reach the desired level in the fight against progressive cancer types is cancer stem cells (CSCs). The ineffectiveness of conventional therapies on CSCs has made it necessary to investigate the molecular mechanisms and signaling pathways used in the survival, drug resistance, and metastasis of CSCs. In this context, studies investigating the biology of CSCs suggest that lipid metabolism and extracellular vesicles are critical for understanding the stemness and metastasis of these cells. These studies have demonstrated that a number of molecules play a vital role in resistant to apoptosis in CSCs, including the cellular FLICE-inhibitor protein (c-FLIP), which inhibits TRAIL-induced extrinsic apoptosis. Another important output of these studies is the demonstration of the relationship of the cancer microenvironment in terms of epithelial-mesenchymal transition, which CSCs frequently use in the metastasis process. In addition, studies investigating the differences in glycosylation observed in CSCs and investigating cancer vaccines are promisng. These findings will strengthen our aresnal in the fight against cancer. In this article, we summarize current molecular studies on CSCs, an important target in novel cancer therapies.
