Ethyl 2-[(2-oxo-2H-chromen-6-yl)-oxy]acetate.

Ethyl 2-[(2-oxo-2H-chromen-6-yl)-oxy]acetate, C13H12O5, a member of the pharmacologically important class of coumarins, crystallizes in the monoclinic C2/c space group in the form of sheets, within which mol-ecules are related by inversion centers and 21 axes. Multiple C-H⋯O weak hydrogen-bonding inter-actions reinforce this pattern. The planes of these sheets are oriented in the approximate direction of the ac face diagonal. Inter-sheet inter-actions are a combination of coumarin system π-π stacking and additional C-H⋯O weak hydrogen bonds between ethyl acet-oxy groups.

Bis[tris-(diiso-butyl-dithio-carbamato)-µ3-sulfido-tri-µ2-di-sulfido-trimolybdenum(IV)] sulfide tetra-hydro-furan monosolvate.

The title compound, [Mo3(C9H18NS2)3(S2)3S]2S, crystallizes on a general position in the monoclinic space group P21/n (No. 14). The cationic [Mo3S7(S2CNiBu2)3]+ fragments are joined by a mono-sulfide dianion that forms close S⋯S contacts to each of the di-sulfide ligands on the side of the Mo3 plane opposite the µ3 2- ligand. The two Mo3 planes are inclined at an angle of 40.637 (15)°, which gives the assembly an open clamshell-like appearance. One µ6-S2-⋯S2 2- contact, at 2.4849 (14) Å, is appreciably shorter than the remaining five, which are in the range 2.7252 (13)-2.8077 (14) Å.

The single-atom R1: a new optimization method to solve crystal structures.

A crystal structure with N atoms in its unit cell can be solved starting from a model with atoms 1 to j - 1 being located. To locate the next atom j, the method uses a modified definition of the traditional R1 factor where its dependencies on the locations of atoms j + 1 to N are removed. This modified R1 is called the single-atom R1 (sR1), because the locations of atoms 1 to j - 1 in sR1 are the known parameters, and only the location of atom j is unknown. Finding the correct position of atom j translates thus into the optimization of the sR1 function, with respect to its fractional coordinates, xj, yj, zj. Using experimental data, it has been verified that an sR1 has a hole near each missing atom. Further, it has been verified that an algorithm based on sR1, hereby called the sR1 method, can solve crystal structures (with up to 156 non-hydrogen atoms in the unit cell). The strategy to carry out this calculation has also been optimized. The main feature of the sR1 method is that, starting from a single arbitrarily positioned atom, the structure is gradually revealed. With the user's help to delete poorly determined parts of the structure, the sR1 method can build the model to a high final quality. Thus, sR1 is a viable and useful tool for solving crystal structures.

Asymmetric by Design: Heteroleptic Coordination Compounds with Redox-Active Dithiolene and 1,2,4,5-Tetrakis(isopropylthio)benzene Ligands.

The 1,2,4,5-tetrakis(alkylthio)benzenes are redox-active organosulfur molecules that support oxidation to a stable radical cation. Their utility as ligands for the assembly of multimetal complexes with tailored functionality/property is unexamined. Here, 1,2,4,5-tetrakis(isopropylthio)benzene (tptbz, 1) is shown to bind PdCl2 at either one end, leaving the other open, or at both ends to form centrosymmetric [Cl2Pd(tptbz)PdCl2], 4. Ligand metathesis between Na2[(N≡C)2C2S2] (Na2mnt) and [Cl2M(tptbz)] (M = Pd, 2; M = Pt, 3) yields [(mnt)M(tptbz)] (M = Pd, 5; M = Pt, 6), but an alternative route involving transmetalation with [(mnt)SnMe2] delivers substantially greater yield. The mixed dithiolene-dithioether compound [(Ph2C2S2)Pt(tptbz)] (8) is formed by a similar transmetalation protocol using [(Ph2C2S2)SnnBu2]. Compounds 5, 6, and 8 are the first such heteroleptic complexes prepared by deliberate synthesis. The cyclic voltammetry of 8 reveals anodic waves at +0.14 and +0.97 V vs Fc+/Fc, which are attributed to successive dithiolene oxidation processes. While oxidized at +0.73 V as a free ligand, the redox-active MO of tptbz is pushed to a higher potential upon coordination to Pt2+ and is inaccessible. Calculations of the structures of [8]+ and of [((Cl2-3,5-C6H3)2C2S2)Pt(tptbz)]+ show that, in the latter, the dithiolene MOs are drawn down in energy into proximity with the tptbz MOs.

Fully Reduced and Mixed-Valent Multi-Copper Aggregates Supported by Tetradentate Diamino Bis(thiolate) Ligands.

Tetradentate diamino bis(thiolate) ligands (l-N2S2(2-)) with saturated linkages between heteroatoms support fully reduced [(Cu(l-N2S2))2Cu2] complexes that bear relevance as an entry point toward molecules featuring the Cu2ICu2II(µ4-S) core composition of nitrous oxide reductase (N2OR). Tetracopper [(Cu(l-N2(SMe2)2))2Cu2] (l-N2(SMe2H)2 = N1,N2-bis(2-methyl-2-mercaptopropane)-N1,N2-dimethylethane-1,2-diamine) does not support clean S atom oxidative addition but undergoes Cl atom transfer from PhICl2 or Ph3CCl to afford [(Cu(l-N2(SMe2)2))3(CuCl)5], 14. When introduced to Cu(I) sources, the l-N2(SArH)2 ligand (l-N2(SArH)2 = N1,N2-bis(2-mercaptophenyl)-N1,N2-dimethylethane-1,2-diamine), made by a newly devised route from N1,N2-bis(2-fluorophenyl)-N1,N2-dimethylethane-1,2-diamine, ultimately yields the mixed-valent pentacopper [(Cu(l-N2SAr2))3Cu2] (19), which has 3-fold rotational symmetry (D3) around a Cu2 axis. The single CuII ion of 19 is ensconced within an equatorial l-N2(SAr)2(2-) ligand, as shown by 14N coupling in its EPR spectrum. Formation of 19 proceeds from an initial, fully reduced product, [(Cu(l-N2SAr2))3Cu2(Cu(MeCN))] (17), which is C2 symmetric and exceedingly air-sensitive. While unreactive toward chalcogen donors, 19 supports reversible reduction to the all-cuprous state; generation of [19]1- and treatment with S atom donors only return 19 because structural adjustments necessary for oxidative addition are noncompetitive with outer-sphere electron transfer. Oxidation of 19 is marked by intense darkening, consistent with greater mixed valency, and by dimerization in the crystalline state to a decacopper species ([20]2+) of S4 symmetry.

Bis[1,2-bis-(4-tert-butyl-phen-yl)ethyl-ene-1,2-di-thiol-ato(1-)]nickel(II) pentane 0.25-solvate.

The title compound, [Ni(C22H26S2)2], 1, is a square-planar D 2h -symmetric compound that occurs on a general position in non-centrosymmetric tetra-gonal P41212 (No. 92) with » eq of n-pentane (C5H12) as co-crystallite. Intra-ligand bond lengths show the di-thiol-ene ligands to be in their half-oxidized radical monoanionic form. Inter-molecular t Bu-C-H⋯arenecentroid and t Bu-C-H⋯NiS2C2 centroid close contacts guide the packing arrangement for 1.

Bis[1,2-bis-(4-chloro-phen-yl)-ethyl-ene-1,2-dithiol-ato(1-)]nickel(II).

The title compound, [Ni(S2C2(C6H4-p-Cl)2)2] or [Ni(C14H8Cl2S2)2], crystallizes in the triclinic space group P as pairs of mol-ecules disposed about an inversion center at the bc face of the cell. Close inter-molecular C-H⋯S (2.884 Å) and C-H⋯Ni (3.032 Å) contacts that are less than the sum of the van der Waals radii appear to induce slight bowing of the mol-ecular planes toward one another. The angles at which the four p-ClC6H4- rings join the NiS2C2 chelate rings [39.37 (9)- 53.41 (6)°] are similarly influenced by these inter-molecular contacts. In the larger packing arrangement, sheets of mol-ecules extend in the direction of the ac face diagonal.

Crystal structure of 4,5-dimethyl-1,3-dioxol-2-one.

The planar title compound 4,5-dimethyl-1,3-dioxol-2-one, C5H6O3, 1, crystallizes with its mol-ecular C 2 axis coincident with a crystallographic mirror plane in space group P21/m. In the plane defined by the b axis and an ac face diagonal, anti-parallel linear strands of 1, formed by simple translation, associate to form sheets with close H⋯H and O⋯O inter-molecular contacts. Between the sheets, parallel strands of 1 place the carbonyl O atom near the five-membered ring centroid of a neighboring mol-ecule with close O⋯O and O⋯C contacts.

Heterotrimetallic Assemblies with 1,2,4,5-Tetrakis(diphenylphosphino)benzene Bridges: Constructs for Controlling the Separation and Spatial Orientation of Redox-Active Metallodithiolene Groups.

Metallodithiolene complexes of the type [(R2C2S2)M(η2-tpbz)] [R = CN, Ph, or p-anisyl; M = Ni2+, Pd2+, or Pt2+; tpbz = 1,2,4,5-tetrakis(diphenylphosphino)benzene] chelate transition metals ions to form trimetallic arrays [[(R2C2S2)M(tpbz)]2M']n+, where M' is square planar Pt2+, tetrahedral Cu+, Ag+, or Au+, or octahedral {ReBr(CO)}/{Re(CO)2}+. Forcing conditions (190 °C reflux in decalin, 72 h) are demanded for the Re+ compounds. With third-row metals at the nexus, the compounds are stable to air. Twelve members of the set have been characterized by X-ray diffraction and reveal dithiolene centroid-centroid distances ranging from 22.4 to 24.0 Å. Folding around each tpbz intrachelate P···P axis such that the MP2/M'P2 planes meet the tpbz P2C6P2 mean plane at non-zero values gives rise to core topologies that appear "S-like" or herringbone-like for M' = Pt2+ or {ReBr(CO)}/{Re(CO)2}+. Calculations reveal that departure from idealized D2h/D2d/C2v symmetries is induced by steric crowding between Ph groups and that dynamic, fluxional behavior is pertinent to the solution phase because multiple, lower-symmetry minima of comparable energy exist. Spectroscopically, the formation of the trimetallic arrays is marked by a shift of the open end 31P nuclear magnetic resonance signal from approximately -14.5 ppm to approximately +41, approximately +20.5, and approximately +28.5 ppm for M' = Pt2+, Au+, and {ReBr(CO)}/{Re(CO)2}+, respectively. Electrochemically, dithiolene-based oxidations are observed for the R = Ph and M' = Pt2+ or Au+ compounds but at potentials that are anodically shifted relative to charge-neutral [[(R2C2S2)M]2(µ-tpbz)]. The compounds reported clarify the possibilities for the synthesis of assemblies in which weakly coupled spins may be created in their modular (R2C2S2)M and M' parts.

Open-Ended Metallodithiolene Complexes with the 1,2,4,5-Tetrakis(diphenylphosphino)benzene Ligand: Modular Building Elements for the Synthesis of Multimetal Complexes.

Open-ended, singly metalated dithiolene complexes with 1,2,4,5-tetrakis(diphenylphosphino)benzene (tpbz) are prepared either by ligand transfer to [Cl2M(tpbz)] from (R2C2S2)SnR'2 (R = CN, R' = Me; R = Me, R' = nBu) or by a direct reaction between tpbz and [M(S2C2R2)2] (M = Ni, Pd, Pt; R = Ph, p-anisyl) in a 1:1 ratio. The formation of dimetallic [(R2C2S2)M(tpbz)M(S2C2R2)] attends these syntheses in modest amounts, but the open-ended compounds are readily separated by silica chromatography. As affirmed by X-ray crystallographic characterization of numerous members of the set, the [(R2C2S2)M(tpbz)] compounds show dithiolene ligands in their fully reduced ene-1,2-dithiolate form conjoined with divalent Group 10 ions. Minor amounts of octahedral [(Ph2C2S2)2PtIV(tpbz)], a presumed intermediate, are isolated from the preparation of [(Ph2C2S2)PtII(tpbz)]. Heterodimetallic [(Ph2C2S2)Pt(tpbz)Ni(S2C2Me2)] is prepared from [(Ph2C2S2)PtII(tpbz)]; its cyclic voltammogram, upon anodic scanning, shows two pairs of closely spaced, but resolved, 1e- oxidations corresponding first to [R2C2S22-] - 1e- → [R2C2S•S-] and then to [R2C2S•S-] - 1e- → [R2(C═S)2]. The open diphosphine of [(R2C2S2)M(tpbz)] can be oxidized to afford open-ended [(R2C2S2)M(tpbzE2)] (E = O, S). Synthesis of the octahedral [(dppbO2)3Ni][I3]2 [dppbO2 = 1,2-bis(diphenylphosphoryl)benzene] suggests that the steric profile of [(R2C2S2)M(tpbzE2)] is moderated enough that three could be accommodated as ligands around a metal ion.

Synthesis and Structures of Polyphenylphenanthrenes.

1,2,3,4,5,6,7,8-Octaphenylphenanthrene (4) and decaphenylphenanthrene (5) were prepared by very short syntheses (two or three steps) from tetraphenylfuran and polybrominated benzene derivatives. The X-ray structures of compounds 4 and 5 show them to be quite crowded, with the phenanthrene cores twisted by about 40° due to the clash of the C4 and C5 phenyl groups. Compound 4 was resolved by chromatography on a chiral support, and its free energy of activation for racemization was determined to be 24.6 kcal mol-1 at 40 °C. Computational studies indicate that compound 5 has a racemization barrier approximately 6 kcal mol-1 lower than 4, and thus 5 would not be configurationally stable at room temperature.

Tris[N,N-bis-(3,5-di-tert-butyl-benz-yl)di-thio-carbamato-κ2 S,S']-µ3-sulfido-tris-µ2-disulfido-triangulo-trimolybdenum(IV) iodide.

The title compound, [Mo3(C31H46NS2)3S7]I, crystallizes on a threefold rotational axis in P31c (space group No. 159). The [Mo3S7(S2CN(CH2C6H3-3,5- t Bu2)2)3]+ cations are arrayed in sheets in the ab plane with inter-ligand hydro-phobic inter-actions between tert-butyl groups guiding the packing arrangement. These cations form stacks parallel to the c axis with a separating distance of 10.9815 (6) Š(the c axis length) between the Mo3 centroids. On the underside of the cluster, opposite the µ3-S2- ligand, the iodide counteranion forms close contacts of 3.166 (2) Šwith the sulfur atoms of the µ2-S2 2- ligands. These contacts are less than the sum of the van der Waals radii of the atoms (1.8 and 2.1 Šfor S and I, respectively), thus indicating an appreciable degree of covalency to the [Mo3S7(S2CN(CH2C6H3-3,5- t Bu2)2)3]+⋯I- inter-actions.

Photocatalytic H2-Evolution by Homogeneous Molybdenum Sulfide Clusters Supported by Dithiocarbamate Ligands.

Irradiation at 460 nm of [Mo3(µ3-S)(µ2-S2)3(S2CNR2)3]I ([2a]I, R = Me; [2b]I, R = Et; [2c]I, R = iBu; [2d]I, R = CH2C6H5) in a mixed aqueous-polar organic medium with [Ru(bipy)3]2+ as photosensitizer and Et3N as electron donor leads to H2 evolution. Maximum activity (300 turnovers, 3 h) is found with R = iBu in 1:9 H2O:MeCN; diminished activity is attributed to deterioration of [Ru(bipy)3]2+. Monitoring of the photolysis mixture by mass spectrometry suggests transformation of [Mo3(µ3-S)(µ2-S2)3(S2CNR2)3]+ to [Mo3(µ3-S)(µ2-S)3(S2CNR2)3]+ via extrusion of sulfur on a time scale of minutes without accumulation of the intermediate [Mo3S6(S2CNR2)3]+ or [Mo3S5(S2CNR2)3]+ species. Deliberate preparation of [Mo3S4(S2CNEt2)3]+ ([3]+) and treatment with Et2NCS21- yields [Mo3S4(S2CNEt2)4] (4), where the fourth dithiocarbamate ligand bridges one edge of the Mo3 triangle. Photolysis of 4 leads to H2 evolution but at ∼25% the level observed for [Mo3S7(S2CNEt2)3]+. Early time monitoring of the photolyses shows that [Mo3S4(S2CNEt2)4] evolves H2 immediately and at constant rate, while [Mo3S7(S2CNEt2)3]+ shows a distinctive incubation prior to a more rapid H2 evolution rate. This observation implies the operation of catalysts of different identity in the two cases. Photolysis solutions of [Mo3S7(S2CNiBu2)3]+ left undisturbed over 24 h deposit the asymmetric Mo6 cluster [(iBu2NCS2)3(µ2-S2)2(µ3-S)Mo3](µ3-S)(µ3-η2,η1-S',η1-S″-S2)[Mo3(µ2-S)3(µ3-S)(S2CNiBu2)2(µ2-S2CNiBu2)] in crystalline form, suggesting that species with this hexametallic composition and core topology are the probable H2-evolving catalysts in photolyses beginning with [Mo3S7(S2CNR2)3]+. When used as solvent, N,N-dimethylformamide (DMF) suppresses H2-evolution but to a greater degree for [Mo3S4(S2CNEt2)4] than for [Mo3S7(S2CNEt2)3]+. Recrystallization of [Mo3S4(S2CNEt2)4] from DMF affords [Mo3S4(S2CNEt2)4(η1,κO-DMF)] (5), implying that inhibition by DMF arises from competition for a Mo coordination site that is requisite for H2 evolution. Computational assessment of [Mo3S4(S2CNMe2)3]+ following addition of 2H+ and 2e- suggests a Mo(H)-µ2(SH) intermediate as the lowest energy species for H2 elimination. An analogous pathway may be available to the Mo6 cluster via dissociation of one end of the µ2-S2CNR2 ligand, a known hemilabile ligand type, in the [Mo3S4]4+ fragment.

Ligand Radicals as Modular Organic Electron Spin Qubits.

The intrinsic redox activity of the dithiolene ligand is presented here as the novel spin host in the design of a prototype molecular electron spin qubit, where the traditional roles of the metal and ligand components in coordination complexes are inverted. A series of paramagnetic bis(dithiolene) complexes with group 10 metals-nickel, palladium, platinum-provides a backdrop to investigate the spin dynamics of the organic ligand radical using pulsed EPR spectroscopy. The temperature dependence of the phase memory time (TM ) is shown to be dependent on the identity of the diamagnetic metal ion, with the short times recorded for platinum a consequence of a diminishing spin-lattice (T1 ) relaxation time driven by spin-orbit coupling. The utility of the radical ligand spin center is confirmed when it delivers one of the longest phase memory times ever recorded for a molecular two-qubit prototype.

Redox-Active Metallodithiolene Groups Separated by Insulating Tetraphosphinobenzene Spacers.

Compounds of the type [(S2C2R2)M(µ-tpbz)M(S2C2R2)] (R = CN, Me, Ph, p-anisyl; M = Ni, Pd, Pt; tpbz = 1,2,4,5-tetrakis(diphenylphosphino)benzene) have been prepared by transmetalation with [(S2C2R2)SnR'2] reagents, by direct displacement of dithiolene ligand from [M(S2C2R2)2] with 0.5 equiv of tpbz, or by salt metathesis using Na2[S2C2(CN)2] in conjunction with X2M(µ-tpbz)MX2 (X = halide). X-ray crystallography reveals a range of topologies (undulating, chair, bowed) for the (S2C2)M(P2C6P2)M(S2C2) core. The [(S2C2R2)M(µ-tpbz)M(S2C2R2)] (R = Me, Ph, p-anisyl) compounds support reversible or quasireversible oxidations corresponding to concurrent oxidation of the dithiolene terminal ligands from ene-1,2-dithiolates to radical monoanions, forming [(-S•SC2R2)M(µ-tpbz)M(-S•SC2R2)]2+. The R = Ph and p-anisyl compounds support a second, reversible oxidation of the dithiolene ligands to their α-dithione form. In contrast, [(S2C2(CN)2)Ni(tpbz)Ni(S2C2(CN)2)] sustains only reversible, metal-centered reductions. Spectroscopic examination of [(-S•SC2( p-anisyl)2)Ni(µ-tpbz)Ni(-S•SC2( p-anisyl)2)]2+ by EPR reveals a near degenerate singlet-triplet ground state, with spectral simulation revealing a remarkably small dipolar coupling constant of 18 × 10-4 cm-1 that is representative of an interspin distance of 11.3 Å. This weak interaction is mediated by the rigid tpbz ligand, whose capacity to electronically insulate is an essential quality in the development of molecular-based spintronic devices.

A dibenzofuran derivative: 2-(pentyloxy)dibenzo[b,d]furan.

The title compound, C17H18O2, crystallizes in two-dimensional sheets, in which the 2-(pentyloxy)dibenzo[b,d]furan molecules are arranged in a head-to-head and tail-to-tail fashion that enables hydrophobic interactions between fully extended 2-pentoxy chains and π-π stacking between dibenzofuran rings in adjacent rings. Nearest intermolecular π-π stacking contacts are 3.3731 (12) Å. The molecule is nearly planar with an r.m.s. deviation of 0.0803 Å from the mean plane defined by the nineteen non-hydrogen atoms.

Ethyl 2-[2-(4-oxo-4H-chromen-2-yl)phenoxy]acetate.

In the title flavonoid derivative, C19H16O5, the chromene portion is planar (r.m.s. deviation = 0.022 Å) with the substituents lying closely to the same plane. The dihedral angle between its mean plane and that of the benzene ring is 4.9 (1)°. This planarity is due, in part, to the presence of a strong intramolecular C-H⋯O hydrogen bond and to two weak C-H⋯O contacts. In the crystal, neighboring molecules are linked by a C-H⋯O hydrogen bond and a C-H⋯π interaction, forming chains along the a-axis direction.

Crystal structure of tetra-iso-butyl-thiuram di-sulfide.

Tetra-kis(2-methyl-prop-yl)thio-per-oxy-dicarbonic di-amide, or tetra-iso-butyl-thiuram di-sulfide, C18H36N2S4, crystallizes in a general position in the triclinic space group P-1 but shows pseudo-C2 symmetry about the di-sulfide bond. The C-S-S-C torsion angle [-85.81 (2)°] and the dihedral angle between the two NCS2 mean planes [85.91 (5)°] are within the range observed for this compound type. Multiple intra- and inter-molecular S⋯H-C close contacts appear to play a role in assisting the specific conformation of the pendant isobutyl groups and the packing arrangement of mol-ecules within the cell. Tetra-iso-butyl-thiuram di-sulfide mol-ecules of one optical configuration form sheets in the plane of the a and b axes. Inversion centers exist between adjoining sheets, which stack along the c axis and alternate in the handedness of their constituent mol-ecules.

Expanding the Scope of Ligand Substitution from [M(S2C2Ph2] (M = Ni2+, Pd2+, Pt2+) To Afford New Heteroleptic Dithiolene Complexes.

The scope of direct substitution of the dithiolene ligand from [M(S2C2Ph2)2] [M = Ni2+ (1), Pd2+ (2), Pt2+ (3)] to produce heteroleptic species [M(S2C2Ph2)2Ln] (n = 1, 2) has been broadened to include isonitriles and dithiooxamides in addition to phosphines and diimines. Collective observations regarding ligands that cleanly produce [M(S2C2Ph2)Ln], do not react at all, or lead to ill-defined decomposition identify soft σ donors as the ligand type capable of dithiolene substitution. Substitution of MeNC from [Ni(S2C2Ph2)(CNMe)2] by L provides access to a variety of heteroleptic dithiolene complexes not accessible from 1. Substitution of a dithiolene ligand from 1 involves net redox disproportionation of the ligands from radical monoanions, -S•SC2Ph2, to enedithiolate and dithione, the latter of which is an enhanced leaving group that is subject to further irreversible reactions.

Binding of carboxylate and trimethylammonium salts to octa-acid and TEMOA deep-cavity cavitands.

In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests (3-8) to two hosts (1 and 2) were measured by 1H NMR and ITC. Each host possessed a unique and well-defined binding pocket, whilst the wide array of amphiphilic guests possessed binding moieties that included: a terminal alkyne, nitro-arene, alkyl halide and cyano-arene groups. Solubilizing head groups for the guests included both positively charged trimethylammonium and negatively charged carboxylate functionality. Measured association constants (K a ) covered five orders of magnitude, ranging from 56 M-1 for guest 6 binding with host 2 up to 7.43 × 106 M-1 for guest 6 binding to host 1.