Gastrodin inhibits prostate cancer proliferation by targeting canonical Wnt/ß-catenin signaling pathway.

Prostate cancer is an epithelial malignant tumor occurring in the prostate and is the most common malignant tumor in the male genitourinary system. In recent years, the incidence of prostate cancer in China has shown a trend of sudden increase. The search for new and effective drugs to treat prostate cancer is therefore extremely important.The canonical Wnt/ß-catenin signaling pathway has been shown to be involved in the regulation of tumor proliferation, migration and differentiation. Activation of the canonical Wnt/ß-Catenin signaling pathway in the prostate has oncogenic effects. Drugs targeting the canonical Wnt/ß-catenin signaling pathway have great potential in the treatment of prostate cancer. In this study, we found that Gastrodin could significantly inhibit the proliferation of prostate cancer cell line PC3 and DU145. Oral administration Gastrodin could significantly inhibit the tumor growth of PC3 cells subcutaneously injected. Gastrodin has an inhibitory effect on canonical Wnt/ß-Catenin signaling pathway in Prostate cancer, and this inhibitory effect can be abolished by Wnt/ß-Catenin agonist LiCl. These findings raise the possibility that Gastrodin can be used in the treatment of Prostate cancer by targeting canonical Wnt/ß-Catenin signaling pathway.

Orientin regulates the proliferation and migration of hepatocellular carcinoma cells.

Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro. The effects of orientin in hepatoma carcinoma cells remain unknown. The aim of this paper is to investigate the effects of orientin on the viability, proliferation, and migration of hepatocellular carcinoma cells in vitro. In this study, we found that orientin could inhibit the proliferation, migration, and the activation of NF-κB signaling pathway in hepatocellular carcinoma cells. An activator of NF-κB signaling pathway, PMA, could abolish the inhibitory effect of orientin on NF-κB signaling pathway and proliferation and migration of Huh7 cells. These findings raise the possibility that orientin can be used in the treatment of hepatocellular carcinoma.

Applications of improved first Rayleigh-Sommerfeld method to analyze the performance of cylindrical microlenses with different f-numbers.

Based on the previous Letter [Opt. Lett. 29, 2345 (2004)], we significantly extend the applications of the improved first Rayleigh-Sommerfeld method (IRSM1) to analyze the focusing performance of cylindrical micro-lenses for different types of profile (continuous or stepwise), different f-numbers (from f/1.5 to f/0.75), and different polarizations (the TE or TM). A number of performance measures of the cylindrical microlenses, such as the focal spot size, the diffraction efficiency, the real focal position, and the normalized sidelobe power, are studied in detail. We compare numerical results obtained by the IRSM1, by the original first Rayleigh-Sommerfeld method (ORSM1), and by the rigorous boundary element method (BEM). For continuously refractive lenses, the results calculated by the IRSM1 are quite close to those obtained by the BEM; in contrast, the results calculated by the ORSM1 significantly deviate from those obtained from the rigorous BEM. For multilevel diffractive lenses, the IRSM1 also provides much more accurate results than the ORSM1. In addition, compared with the BEM, a notable advantage of the IRSM1 is much lower computer memory and time consumption in computations.

Improved first Rayleigh-sommerfeld method for analysis of cylindrical microlenses with small f-numbers.

An improved first Rayleigh-Sommerfeld method (IRSM1) is proposed and applied to the analysis of cylindrical microlenses with small f-numbers. Numerical results obtained by both the IRSM1 and the original Rayleigh-Sommerfeld method (ORSM1) are compared with those obtained by the rigorous boundary element method (BEM). For both refractive and diffractive lenses, the results obtained by the IRSM1 are close to those obtained by the BEM even for small f-numbers; by contrast, the results by the ORSM1 differ significantly from those obtained by the BEM. Moreover, the IRSM1 uses much less time and computer memory in the computations than the BEM.

Analysis of a cylindrical microlens array with long focal depth by a rigorous boundary-element method and scalar approximations.

We investigated the focal characteristics of open-regional cylindrical microlens arrays with long focal depth by using a rigorous boundary-element method (BEM) and three scalar methods, i.e., a Kirchhoff and two Rayleigh-Sommerfeld diffraction integral forms. Numerical analysis clearly shows that the model cylindrical microlens arrays with different f-numbers can generate focusing beams with both long focal depth and high transverse resolution. The performance of the cylindrical microlens arrays, such as extended focal depth, relative extended focal depth, diffraction efficiency, and focal spot size, is appraised and analyzed. From a comparison of the results obtained by the rigorous BEM and by scalar approximations, we found that the results are quite similar when the f-number equals f/1.6; however, they are quite different for f/0.8. We conclude that the BEM should be adopted to analyze the performance of a microlens array system whose f-number is less than f/1.0.

Analysis of a closed-boundary axilens with long focal depth and high transverse resolution based on rigorous electromagnetic theory.

We find that a microcylindrical axilens with a closed boundary and with an f-number less than 1 still can achieve the properties of long focal depth and high transverse resolution, unlike a microcylindrical axilens with an open boundary, which fails to maintain those properties for low f-numbers. The focusing characteristics of the closed-boundary axilens and the open-boundary axilens are numerically investigated based on the boundary integral method. The numerical results show that the ratio of the extended focal depth of the closed-boundary axilens to the focal depth of the conventional microlens can reach up to 1.26 and 2.12 for the preset focal depths 3 and 5 microm, respectively, even though the f-number is reduced to 1/3.