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1.
Eur Radiol ; 32(5): 3447-3457, 2022 May.
Article En | MEDLINE | ID: mdl-34997284

OBJECTIVE: The aim of the current study was to systematically assess coronary artery calcium (CAC) detection and quantification for spectral photon-counting CT (SPCCT) in comparison to conventional CT and, in addition, to evaluate the possibility of radiation dose reduction. METHODS: Routine clinical CAC CT protocols were used for data acquisition and reconstruction of two CAC containing cylindrical inserts which were positioned within an anthropomorphic thorax phantom. In addition, data was acquired at 50% lower radiation dose by reducing tube current, and slice thickness was decreased. Calcifications were considered detectable when three adjacent voxels exceeded the CAC scoring threshold of 130 Hounsfield units (HU). Quantification of CAC (as volume and mass score) was assessed by comparison with known physical quantities. RESULTS: In comparison with CT, SPCCT detected 33% and 7% more calcifications for the small and large phantoms, respectively. At reduced radiation dose and reduced slice thickness, small phantom CAC detection increased by 108% and 150% for CT and SPCCT, respectively. For the large phantom size, noise levels interfered with CAC detection. Although comparable between CT and SPCCT, routine protocols CAC quantification showed large deviations (up to 134%) from physical CAC volume. At reduced radiation dose and slice thickness, physical volume overestimations decreased to 96% and 72% for CT and SPCCT, respectively. In comparison with volume scores, mass score deviations from physical quantities were smaller. CONCLUSION: CAC detection on SPCCT is superior to CT, and was even preserved at a reduced radiation dose. Furthermore, SPCCT allows for improved physical volume estimation. KEY POINTS: • In comparison with conventional CT, increased coronary artery calcium detection (up to 156%) for spectral photon-counting CT was found, even at 50% radiation dose reduction. • Spectral photon-counting CT can more accurately measure physical volumes than conventional CT, especially at reduced slice thickness and for high-density coronary artery calcium. • For both conventional and spectral photon-counting CT, reduced slice thickness reconstructions result in more accurate physical mass approximation.


Calcinosis , Coronary Artery Disease , Calcinosis/diagnostic imaging , Calcium , Coronary Artery Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Humans , Phantoms, Imaging , Radiation Dosage , Tomography, X-Ray Computed/methods
2.
Eur Radiol ; 32(1): 152-162, 2022 Jan.
Article En | MEDLINE | ID: mdl-34255159

OBJECTIVE: The aim of the current study was, first, to assess the coronary artery calcium (CAC) scoring potential of spectral photon-counting CT (SPCCT) in comparison with computed tomography (CT) for routine clinical protocols. Second, improved CAC detection and quantification at reduced slice thickness were assessed. METHODS: Raw data was acquired and reconstructed with several combinations of reduced slice thickness and increasing strengths of iterative reconstruction (IR) for both CT systems with routine clinical CAC protocols for CT. Two CAC-containing cylindrical inserts, consisting of CAC of different densities and sizes, were placed in an anthropomorphic phantom. A specific CAC was detectable when 3 or more connected voxels exceeded the CAC scoring threshold of 130 Hounsfield units (HU). For all reconstructions, total CAC detectability was compared between both CT systems. Significant differences in CAC quantification (Agatston and volume scores) were assessed with Mann-Whitney U tests. Furthermore, volume scores were compared with the known CAC physical. RESULTS: CAC scores for routine clinical protocols were comparable between SPCCT and CT. SPCCT showed 34% and 4% higher detectability of CAC for the small and large phantom, respectively. At reduced slice thickness, CAC detection increased by 142% and 169% for CT and SPCCT, respectively. In comparison with CT, volume scores from SPCCT were more comparable with the physical volume of the CAC. CONCLUSION: CAC scores using routine clinical protocols are comparable between conventional CT and SPCCT. The increased spatial resolution of SPCCT allows for increased detectability and more accurate CAC volume estimation. KEY POINTS: • Coronary artery calcium scores using routine clinical protocols are comparable between conventional CT and spectral photon-counting CT. • In comparison with conventional CT, increased coronary artery calcium detectability was shown for spectral photon-counting CT due to increased spatial resolution. • Volumes scores were more accurately determined with spectral photon-counting CT.


Calcium , Coronary Artery Disease , Coronary Artery Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Humans , Phantoms, Imaging , Tomography, X-Ray Computed
3.
Eur Radiol ; 31(7): 5324-5334, 2021 Jul.
Article En | MEDLINE | ID: mdl-33449188

OBJECTIVES: To compare the spectral performance of dual-energy CT (DECT) platforms using task-based image quality assessment based on phantom data. MATERIALS AND METHODS: Two CT phantoms were scanned on four DECT platforms: fast kV-switching CT (KVSCT), split filter CT (SFCT), dual-source CT (DSCT), and dual-layer CT (DLCT). Acquisitions on each phantom were performed using classical parameters of abdomen-pelvic examination and a CTDIvol at 10 mGy. Noise power spectrum (NPS) and task-based transfer function (TTF) were evaluated from 40 to 140 keV of virtual monoenergetic images. A detectability index (d') was computed to model the detection task of two contrast-enhanced lesions as function of keV. RESULTS: The noise magnitude decreased from 40 to 70 keV for all DECT platforms, and the highest noise magnitude values were found for KVSCT and SFCT and the lowest for DSCT and DLCT. The average NPS spatial frequency shifted towards lower frequencies as the energy level increased for all DECT platforms, smoothing the image texture. TTF values decreased with the increase of keV deteriorating the spatial resolution. For both simulated lesions, higher detectability (d' value) was obtained at 40 keV for DLCT, DSCT, and SFCT but at 70 keV for KVSCT. The detectability of both simulated lesions was highest for DLCT and DSCT. CONCLUSION: Highest detectability was found for DLCT for the lowest energy levels. The task-based image quality assessment used for the first time for DECT acquisitions showed the benefit of using low keV for the detection of contrast-enhanced lesions. KEY POINTS: • Detectability of both simulated contrast-enhanced lesions was higher for dual-layer CT for the lowest energy levels. • The image noise increased and the image texture changed for the lowest energy levels. • The detectability of both simulated contrast-enhanced lesions was highest at 40 keV for all dual-energy CT platforms except for fast kV-switching platform.


Radiography, Dual-Energy Scanned Projection , Tomography, X-Ray Computed , Abdomen/diagnostic imaging , Humans , Phantoms, Imaging , Signal-To-Noise Ratio
4.
Diagn Interv Imaging ; 101(5): 299-310, 2020 May.
Article En | MEDLINE | ID: mdl-32173289

PURPOSE: To compare the quantitative and qualitative lung perfusion data acquired with dual energy CT (DECT) to that acquired with a large field-of-view cadmium-zinc-telluride camera single-photon emission CT coupled to a CT system (SPECT-CT). MATERIALS AND METHODS: A total of 53 patients who underwent both dual-layer DECT angiography and perfusion SPECT-CT for pulmonary hypertension or pre-operative lobar resection surgery were retrospectively included. There were 30 men and 23 women with a mean age of 65.4±17.5 (SD)years (range: 18-88years). Relative lobar perfusion was calculated by dividing the amount (of radiotracer or iodinated contrast agent) per lobe by the total amount in both lungs. Linear regression, Bland-Altman analysis, and Pearson's correlation coefficient were also calculated. Kappa test was used to test agreements in morphology and severity of perfusion defects assessed on SPECT-CT and on DECT iodine maps with a one-month interval. Wilcoxon rank sum test was used to compare the sharpness of perfusion defects and radiation dose among modalities. RESULTS: Strong correlations for relative lobar perfusion using linear regression analysis and Pearson's correlation coefficient (r=0.93) were found. Bland-Altman analysis revealed a -0.10 bias, with limits of agreement between [-6.01; 5.81]. With respect to SPECT- CT as standard of reference, the sensitivity, specificity, PPV, NPV, accuracy for lobar perfusion defects were 89.4% (95% CI: 82.6-93.4%), 96.5% (95% CI: 92.1-98.5%), 95.6% (95% CI: 90.9-97.8%), 91.4% (95% CI: 85.6-94.9%) and 93.0% (95% CI: 87.6-96.1%) respectively. High level of agreement was found for morphology and severity of perfusion defects between modalities (Kappa=0.84 and 0.86 respectively) and on DECT images among readers (Kappa=0.94 and 0.89 respectively). A significantly sharper delineation of perfusion defects was found on DECT images (P<0.0001) using a significantly lower equivalent dose of 4.1±2.3 (SD) mSv (range: 1.9-11.85mSv) compared to an equivalent dose of 5.3±1.1 (SD) mSv (range: 2.8-7.3mSv) for SPECT-CT, corresponding to a 21.2% dose reduction (P=0.0004). CONCLUSION: DECT imaging shows strong quantitative correlations and qualitative agreements with SPECT-CT for the evaluation of lung perfusion.


Lung , Tomography, X-Ray Computed , Adolescent , Aged , Female , Humans , Lung/diagnostic imaging , Male , Middle Aged , Perfusion , Retrospective Studies , Sensitivity and Specificity , Tomography, Emission-Computed, Single-Photon , Young Adult
5.
Diagn Interv Imaging ; 101(5): 289-297, 2020 May.
Article En | MEDLINE | ID: mdl-31932228

PURPOSE: To determine the lowest suitable dose level for the detection of pulmonary arteriovenous malformation (PAVM) using a task-based image quality assessment. MATERIAL AND METHODS: A phantom was scanned using the standard chest protocol (STD) and 4 other ultra-low dose protocols (ULD) using various kVp. Raw data were reconstructed using level 5 of the hybrid iterative reconstruction algorithm (iDose4) for the STD protocol, and level 6 of iDose4 and levels 1 to 3 of model-based iterative reconstruction (IMR) for the ULD protocols. Both quantitative criteria and qualitative analysis were used to compare protocols. Noise-power-spectrum and Task-based transfer function were computed using imQuest software. The detectability-index (d') was computed for the detection of PAVM. A subjective analysis was performed by 2 chest radiologists to validate the image-quality obtained on the anthropomorphic phantom for all protocols. RESULTS: Similar d' values were found for ULD-140 using iDose4 6 compared to STD protocol. Greater d' values were found for all ULD protocols using IMR compared to STD. Subjective image quality was rated as acceptable to excellent for ULD-140 and ULD-120 for all reconstruction types, for ULD-100 and ULD-80 using IMR2, and for ULD-100 using IMR1. Image smoothing was poor for IMR3 for ULD-100 and ULD-80. Finally, the ULD-80 protocol reconstructed with IMR2 was chosen for the detection of PAVM. With this protocol, the dose (CTDIvol of 0.3mGy) was reduced by 91% compared with the STD protocol. CONCLUSION: A dose level as low as 0.3mGy reconstructed with IMR2 provides an image quality suitable for the detection of PAVM.


Arteriovenous Malformations , Radiographic Image Interpretation, Computer-Assisted , Algorithms , Arteriovenous Malformations/diagnostic imaging , Humans , Phantoms, Imaging , Radiation Dosage , Tomography, X-Ray Computed
6.
Diagn Interv Imaging ; 100(3): 177-183, 2019 Mar.
Article En | MEDLINE | ID: mdl-30497958

INTRODUCTION: The purpose of this study was to develop a convolutional neural network (CNN) to determine the extent of over-scanning in the Z-direction associated with lung computed tomography (CT) examinations. MATERIALS AND METHODS: The CT examinations of 250 patients were used to train the machine learning software and 100 were used to validate the results. Each lung CT examination was divided into cervical, lung, and abdominal areas by the CNN and 2 independent radiologists, and the length of each area was measured. Every part above or below the lung marks was labeled as over-scanning. The accuracy of the CNN was calculated after the training phase and agreement between CNN and radiologists was assessed using kappa statistics during the validation phase. After validation the software was used to estimate the length of each of the three areas and the total over-scanning in further 1000 patients. RESULTS: An accuracy of 0.99 was found for the testing dataset and a very good agreement (kappa=0.98) between the CNN and the radiologists' evaluation was found for the validation dataset. Over-scanning was 22.8% with the CNN and 22.2% with the radiologists. The degree of over-scanning was 22.6% in 1000 lung CT examinations. CONCLUSION: Our study shows a substantial over estimation of the length of the area to be scanned during lung CT and thus an unnecessary patient's over-exposure to ionizing radiation. This over-scanning can be assessed easily, reliably and quickly using CNN.


Lung/diagnostic imaging , Machine Learning , Neural Networks, Computer , Tomography, X-Ray Computed/methods , Artificial Intelligence , Humans , Sensitivity and Specificity
8.
Diagn Interv Imaging ; 96(9): 885-90, 2015 Sep.
Article En | MEDLINE | ID: mdl-25697831

Cardiac magnetic resonance (CMR) provides a high signal-to-noise ratio, high spatial and temporal resolutions, as well as a delayed-enhancement sequence and is therefore considered a reference technique in the field of cardiac imaging. However, currently available sequences are not adequate to assess some pathologic conditions, such as myocardial edema. T2 mapping sequences generate parametric images that are based on the transverse relaxation time (T2) for each voxel. In case of edema, the T2 relaxation time is longer. This review summarizes current knowledge on CMR T2 mapping for assessing myocardial edema.


Cardiomyopathies/diagnosis , Edema/diagnosis , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Myocardium/pathology , Biopsy , Cardiomyopathies/pathology , Edema/pathology , Endocardium/pathology , Humans , Sensitivity and Specificity
9.
Radiat Prot Dosimetry ; 164(1-2): 116-9, 2015 Apr.
Article En | MEDLINE | ID: mdl-25342609

The objective of this study was to propose diagnostic reference levels (DRLs) for coronary computed tomography angiography (CCTA), in the context of a large variability in patient radiation dose, and the lack of European recommendations. Volume Computed Tomography Dose Index (CTDIvol) and dose-length product (DLP) were collected from 460 CCTAs performed over a 3-month period at eight French hospitals. CCTAs (∼50 per centre) were performed using the routine protocols of the centres, and 64- to 320-detector CT scanners. ECG gating was prospective (n = 199) or retrospective (n = 261). The large gap in dose between these two modes required to propose specific DRLs: 26 and 44 mGy for CTDIvol, and 370 and 970 mGy cm for DLP, respectively. This study confirms the large variability in patient doses during CCTA and underlines the need for the optimisation of cardiac acquisition protocols. Availability of national DRLs should be mandatory in this setting.


Coronary Angiography/statistics & numerical data , Coronary Angiography/standards , Radiometry/statistics & numerical data , Radiometry/standards , Tomography, X-Ray Computed/statistics & numerical data , Tomography, X-Ray Computed/standards , Radiation Dosage , Reference Values , Surveys and Questionnaires
10.
Diagn Interv Imaging ; 96(3): 265-72, 2015 Mar.
Article En | MEDLINE | ID: mdl-25543870

OBJECTIVE: Despite the obligatory recording of doses administered to patients during CT scans, this data is not easily accessible. The objective of this study was to implement and validate a computerised automated dose-recording system for CT scans, for a single radiology department. MATERIAL AND METHODS: Every patient undergoing a CT scan in our department over a one-year period was included in the study. The CT scanner was upgraded after eight months (installation of iterative reconstruction and choice of an additional voltage of 100 kV). The system recorded, from DICOM image headers, the patient data and technical acquisition parameters. The statistical analysis compared the dose length products (DLP) before and after the upgrade, and compared them with the diagnostic reference levels (DRL). RESULTS: Four thousand seven hundred and ninety-five CT scans were included (2141 before the upgrade and 2654 after). For all of the acquisition protocols tested, there was a reduction in DLP after the upgrade. The mean reduction was 30%, with a range of 17% to 44% depending on the protocol. After the upgrade, all of the mean DLPs were under the DRL thresholds (P<0.0001). CONCLUSION: The proposed tool enabled systematic recording of the doses of radiation used in CT scans. It confirmed the significant reduction in the dose resulting from the implementation of iterative reconstruction, and enabled an exhaustive and rapid control of the respect of DRLs.


Image Processing, Computer-Assisted , Medical Records Systems, Computerized , Radiation Dosage , Radiation Exposure , Tomography, X-Ray Computed/methods , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Radiology Department, Hospital , Young Adult
11.
Magn Reson Imaging ; 32(10): 1237-41, 2014 Dec.
Article En | MEDLINE | ID: mdl-25159472

PURPOSE: To compare diffusion weighted imaging with background suppression (DWIBS) sequence with classic spectral diffusion sequence (DWI) with and without respiratory gating in mediastinal lymph node analysis at 3T. MATERIALS AND METHODS: 26 patients scheduled for mediastinoscopic lymph node analysis, prospectively undergone a thoracic 3T MRI with DWIBS (FatSat=STIR; TR/TE=6674.1/44.7ms; IR=260 ms) and DWI sequences (FatSat=SPIR; TR/TE=1291/59.6 ms) (b=0-400-800 s/mm2) with and without (free breathing) respiratory gating. Images at b=800 were analyzed by two radiologists. They performed qualitative analysis of fat-sat homogeneity and motion artifacts, rated from 0 to 4, and quantitative evaluation by studying signal to background (STB) of lymph nodes. RESULTS: Quality of fat suppression was significantly higher for DWIBS than for DWI both for free-breathing (score 3.48±0.65 vs. 1.76±0.96, p<0.0001) and respiratory-gated scans (3.17±0.77 vs. 1.72±0.73, p=0.0001). Similarly, artifacts were reduced with DWIBS (3.16±0.47 vs. 1.76±0.59, p<0.0001; 3.0±0.73 vs. 2.04±0.53, p=0.0001). Quantitative analysis showed higher STB with DWIBS (3.26±1.83 vs. 0.98±0.44, p<0.0001; 3.56±, 2.09 vs. 0.92±0.59, p<0.0001). Gating did not improve image quality and STB on DWIBS (p>0.05). CONCLUSION: In thoracic MRI, ungated DWIBS sequence improves fat-sat homogeneity, reduces motion artifacts and increases STB of lymph nodes. Respiratory gating does not improve DWIBS image quality.


Diffusion Magnetic Resonance Imaging , Image Processing, Computer-Assisted , Lymph Nodes/pathology , Magnetic Resonance Imaging , Mediastinum/pathology , Adipose Tissue/pathology , Adult , Aged , Artifacts , Female , Humans , Male , Middle Aged , Motion , Prospective Studies , Radiology , Respiration , Water/chemistry
12.
Br J Radiol ; 87(1040): 20130798, 2014 Aug.
Article En | MEDLINE | ID: mdl-24874766

OBJECTIVE: To evaluate the capabilities of photon counting spectral CT to differentiate components of coronary atherosclerotic plaque based on differences in spectral attenuation and iodine-based contrast agent concentration. METHODS: 10 calcified and 13 lipid-rich non-calcified histologically demonstrated atheromatous plaques from post-mortem human coronary arteries were scanned with a photon counting spectral CT scanner. Individual photons were counted and classified in one of six energy bins from 25 to 70 keV. Based on a maximum likelihood approach, maps of photoelectric absorption (PA), Compton scattering (CS) and iodine concentration (IC) were reconstructed. Intensity measurements were performed on each map in the vessel wall, the surrounding perivascular fat and the lipid-rich and the calcified plaques. PA and CS values are expressed relative to pure water values. A comparison between these different elements was performed using Kruskal-Wallis tests with pairwise post hoc Mann-Whitney U-tests and Sidak p-value adjustments. RESULTS: RESULTS for vessel wall, surrounding perivascular fat and lipid-rich and calcified plaques were, respectively, 1.19 ± 0.09, 0.73 ± 0.05, 1.08 ± 0.14 and 17.79 ± 6.70 for PA; 0.96 ± 0.02, 0.83 ± 0.02, 0.91 ± 0.03 and 2.53 ± 0.63 for CS; and 83.3 ± 10.1, 37.6 ± 8.1, 55.2 ± 14.0 and 4.9 ± 20.0 mmol l(-1) for IC, with a significant difference between all tissues for PA, CS and IC (p < 0.012). CONCLUSION: This study demonstrates the capability of energy-sensitive photon counting spectral CT to differentiate between calcifications and iodine-infused regions of human coronary artery atherosclerotic plaque samples by analysing differences in spectral attenuation and iodine-based contrast agent concentration. ADVANCES IN KNOWLEDGE: Photon counting spectral CT is a promising technique to identify plaque components by analysing differences in iodine-based contrast agent concentration, photoelectric attenuation and Compton scattering.


Coronary Artery Disease/diagnostic imaging , Plaque, Atherosclerotic/diagnostic imaging , Tomography, X-Ray Computed/methods , Autopsy , Contrast Media , Humans , Photons , Radiographic Image Interpretation, Computer-Assisted , Scattering, Radiation
13.
AJNR Am J Neuroradiol ; 35(3): 568-72, 2014 Mar.
Article En | MEDLINE | ID: mdl-24136645

BACKGROUND AND PURPOSE: The first part of this study assessed the potential of MDCT with a CTA examination of the aorta and the coronary, cervical, and intracranial vessels in the etiologic work-up of TIA or ischemic stroke compared with established imaging methods. The objective of the second part of this study was to assess the atherosclerotic extent by use of MDCT in these patients. MATERIALS AND METHODS: From August 2007 to August 2011, a total of 96 patients with ischemic stroke or TIA without an evident cardioembolic source were enrolled. All patients underwent MDCT. Atherosclerotic extent was classified in 0, 1, 2, 3, and 4 atherosclerotic levels according to the number of arterial territories (aortic arch, coronary, cervical, intracranial) affected by atherosclerosis defined as ≥ 50% cervical, intracranial, or coronary stenosis or ≥ 4-mm aortic arch plaque. RESULTS: There were 91 patients who had an interpretable MDCT. Mean age was 67.4 years (± 11 years), and 75 patients (83.3%) were men. The prevalence of 0, 1, 2, 3, and 4 atherosclerotic levels was 48.3%, 35.2%, 12.1%, 4.4%, and 0%, respectively. Aortic arch atheroma was found in 47.6% of patients with 1 atherosclerotic level. The combination of aortic arch atheroma and cervical stenosis was found in 63.6% of patients with ≥ 2 atherosclerotic levels. Patients with ≥ 2 atherosclerotic levels were older than patients with < 2 atherosclerotic levels (P = .04) in univariate analysis. CONCLUSIONS: MDCT might be useful to assess the extent of atherosclerosis. It could help to screen for high-risk patients who could benefit from a more aggressive preventive strategy.


Atherosclerosis/complications , Atherosclerosis/diagnostic imaging , Brain Ischemia/etiology , Ischemic Attack, Transient/etiology , Multidetector Computed Tomography/methods , Stroke/etiology , Aged , Female , Humans , Male , Middle Aged
15.
Med Image Anal ; 15(4): 477-88, 2011 Aug.
Article En | MEDLINE | ID: mdl-21419689

This paper describes an evaluation framework that allows a standardized and objective quantitative comparison of carotid artery lumen segmentation and stenosis grading algorithms. We describe the data repository comprising 56 multi-center, multi-vendor CTA datasets, their acquisition, the creation of the reference standard and the evaluation measures. This framework has been introduced at the MICCAI 2009 workshop 3D Segmentation in the Clinic: A Grand Challenge III, and we compare the results of eight teams that participated. These results show that automated segmentation of the vessel lumen is possible with a precision that is comparable to manual annotation. The framework is open for new submissions through the website http://cls2009.bigr.nl.


Angiography/methods , Carotid Arteries/diagnostic imaging , Carotid Stenosis/diagnostic imaging , Imaging, Three-Dimensional/methods , Pattern Recognition, Automated/methods , Radiographic Image Interpretation, Computer-Assisted/methods , Tomography, X-Ray Computed/methods , Algorithms , Humans , Radiographic Image Enhancement/methods , Reproducibility of Results , Sensitivity and Specificity
16.
Br J Radiol ; 84(997): 51-7, 2011 Jan.
Article En | MEDLINE | ID: mdl-21172966

OBJECTIVE: Our aim was to compare image quality, coronary segment assessability and radiation dose in prospectively gated axial (PGA) coronary CT angiography (CTA) and conventional retrospectively gated helical (RGH) coronary CTA. METHODS: Institutional review committee approval and informed consent were obtained. RGH CTA was performed in 41 consecutive patients (33 males, 8 females; mean age 52.6 years), then the PGA CTA technique was evaluated in 41 additional patients (24 males, 17 females; mean age 57.3 years) all with a pre-scan heart rate of ≤70 beats per minute (bpm). Two radiologists, blinded to clinical information, independently scored subjective image quality on a five-point ordinal scale. RESULTS: The mean effective dose in the PGA group was 4.7±0.9 mSv, representing a 69% dose reduction compared with the RGH CTA group (15.1±1.9 mSv, p<0.001). The mean segmental image quality score was significantly higher in the PGA group (3.4 vs 3.2) than in the RGH CTA group (p<0.005). The percentage of assessable segments was 98.1% in the PGA group and 97.3% in the RGH group (p = 0.610). CONCLUSION: PGA CTA offers a significant reduction in radiation dose compared with RGH CTA, with comparable image quality for patients with heart rates below 70 bpm.


Coronary Angiography/methods , Coronary Artery Disease/diagnostic imaging , Tomography, Spiral Computed/methods , Electrocardiography/methods , Female , Humans , Image Processing, Computer-Assisted , Male , Middle Aged , Prospective Studies , Radiation Dosage , Retrospective Studies
17.
J Neuroradiol ; 38(3): 148-55, 2011 Jul.
Article En | MEDLINE | ID: mdl-20728218

PURPOSE: To evaluate the agreement and diagnostic accuracy of Contrast enhanced magnetic resonance angiography (CE-MRA), Doppler ultrasound (DUS) and Digital subtraction angiography (DSA) in the assessment of carotid stenosis. METHODS: DUS, CE-MRA and DSA were performed in 56 patients included in the Carotide-angiographie par résonance magnétique-échographie-doppler-angioscanner (CARMEDAS) multicenter study with a carotid stenosis ≥ 50%. Three readers evaluated stenoses on CE-MRA and DSA (NASCET criteria). Velocities criteria were used for stenosis estimation on DUS. RESULTS: CE-MRA had a sensitivity and specificity of 96-98% and 66-83% respectively for carotid stenoses ≥ 50% and a sensitivity and specificity of 94% and 76-84% respectively for carotid stenoses ≥ 70%. The interobserver agreement of CE-MRA was excellent, except for moderate stenoses (50-69%). DUS had a sensitivity and specificity of 88 and 75% respectively for carotid stenoses ≥ 50% and a sensitivity and specificity of 83 and 86% respectively for carotid stenoses ≥ 70%. Combined concordant CE-MRA and DUS had a sensitivity and specificity of 100 and 85-90% respectively for carotid stenoses ≥ 50% and a sensitivity and specificity of 96-100% and 80-87% respectively for carotid stenoses ≥ 70%. The positive predictive value of the association CE-MRA and DUS for carotid stenoses ≥ 70% is calculated between 77 and 82% while the negative predictive value is calculated between 97 and 100%. CE-MRA and DUS have concordant findings in 63-72%, and the overestimations cases were recorded only for carotid stenosis ≤ 69%. CONCLUSION: Combined DUS-CE-MRA is excellent for evaluation of severe stenosis but remains debatable in moderate stenosis (50-69%) due to the risk of overestimations.


Carotid Stenosis/diagnosis , Imaging, Three-Dimensional , Magnetic Resonance Angiography , Ultrasonography, Doppler , Aged , Aged, 80 and over , Carotid Stenosis/diagnostic imaging , Carotid Stenosis/pathology , Contrast Media , Female , Humans , Image Interpretation, Computer-Assisted , Male , Middle Aged , Predictive Value of Tests , Sensitivity and Specificity
18.
J Radiol ; 91(2): 185-94, 2010 Feb.
Article Fr | MEDLINE | ID: mdl-20389265

A third of cerebrovascular accidents are a complication from carotid artery plaque. In addition to the degree of stenosis, plaque composition and morphology are key elements in determining the probability of complication from the atherosclerotic plaque. High resolution MRI can characterize plaque composition and morphology and therefore help identify unstable plaque. The purpose of this review is to summarize recent concepts on unstable plaque and underlying inflammation. The signal characteristics of the different components of plaque on high resolution MRI then be reviewed. Finally, current morphological and functional criteria for unstable plaque will be discussed.


Carotid Artery Diseases/diagnosis , Magnetic Resonance Imaging , Humans
19.
J Radiol ; 90(9 Pt 2): 1172-5, 2009 Sep.
Article Fr | MEDLINE | ID: mdl-19752827

The recent and future advancements that are known in the field of cardiac imaging imply an optimal training of the operators. This training concerns medical specialists whether originating from radiology or cardiology. The training of the medical specialists in cardiac imaging entitles 3 main essential steps: The basic training taking place within each specialty, allowing the fellow to get acquainted with the clinical and technical basics. The specialized training, delivered principally in post-residency. This training must include an upgrading of each specialty in the domain that does not concern it (a technical base for the cardiologist, a physio-pathological and clinical base for the radiologist). It must include a specific theoretical training covering all aspects of cardiac imaging as well as practical training in a certified training centre. The continuous medical training and maintenance of skills that allow a sustained activity in the field and the obligation to regularly participate in the actions of specific validated training. The different aspects of these rules are exposed in this chapter.


Heart Diseases/diagnosis , Radiology/education , Diagnostic Imaging , Guidelines as Topic , Humans
20.
Eur J Pediatr Surg ; 19(2): 113-6, 2009 Apr.
Article En | MEDLINE | ID: mdl-19242907

Pseudoaneurysm of the dorsalis pedis artery is an extremely rare entity with only 3 pediatric cases previously presented in the English literature. We describe a new case and discuss the clinical presentation and surgical management. A 6-year-old boy was referred to our clinic because of a pulsatile tumor of the right dorsal foot increasing in size. A focused history found a low grade trauma to the dorsal foot one year previously. Magnetic resonance imaging revealed a pseudoaneurysm of the DPA. Resection of the pseudoaneurysm was completed without complications. Pseudoaneurysm of the DPA is a very uncommon cause of soft tissue mass of the dorsal foot. It can appear after low grade trauma. Treatment is surgical.


Aneurysm, False/diagnosis , Aneurysm, False/surgery , Foot/blood supply , Thrombosis/surgery , Tibial Arteries , Aneurysm, False/etiology , Child , Foot Injuries/complications , Humans , Male , Thrombosis/diagnosis , Thrombosis/etiology , Treatment Outcome , Vascular Surgical Procedures/methods
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