[Immune activation and inflammation in chronic heart failure].

This survey shows that among chronic heart failure (CHF) and its characteristic inflammation observed mutual activation. Given the role of inflammation in the pathophysiology of heart failure, it is to study how the combination drug treatment of CHF, its variants influence on markers of inflammation. It is expedient to determine not only the level of cytokines, but also acute phase proteins (haptoglobin, seroglikoidy C3-complement, transferrin), reflecting inflammation and necrosis in the connective tissue, as well as IgA, IgG, IgM and protein spectrum. The importance of the study of haptoglobin due to its involvement in the metabolism of hemoglobin and transferrin--the exchange of iron.

[CHAPERONES FUNCTION HSP60 AND HSP90 AND THEIR ROLE IN CARDIAC PATHOLOGY].

In review provides information about the function oft the body of chaperones and their role in the development of pathological processes, including--atherosclerosis and coronary heart disease. Marked comminications systems chaperones to the immune and endocrine systems, and inflammation.

[Effect of pharmacotherapy of chronic heart failure (CHF) on the parameters of hemogram].

Found that different versions of the combined drug therapy of chronic heart failure accompanied by an increase of erythrocytes, hemoglobin in the blood of patients, color index, tended to increase hematocrit. The most pronounced changes are marked valid in the group of patients receiving the combination of ACE inhibitors + ARB-II + beta-blockers + diuretics. Found to have a direct positive correlation between hemoglobin levels and distance 6-minute test, the back - between hemoglobin and end-diastolic volume of the left ventricle, the functional class of heart failure. The number of red blood cells inversely correlated with functional class of heart failure, a direct positive - with a distance of 6-minute test.

[Biomarkers of iron metabolism and inflammation in patients with chronic heart failure and various types of left ventricular dysfunction].

Study the level of some of the indicators of iron metabolism and inflammatory markers in patients with chronic heart failure due to hypertension and coronary heart disease. The results of the study in systolic and diastolic dysfunction of the left ventricle, the varying degrees of severity of heart failure. The level of the studied parameters determined by the severity of heart failure and does not depend on the nature of left ventricular dysfunction.

[The role of the killer activity of the peripheral blood lymphocytes in the pathogenesis of rheumatism]. / Rol' killernoi aktivnosti limfotsitov perifericheskoi krovi v patogeneze revmatizma.

A total of 49 patients with rheumatism running a sluggish course, were examined, as were those with decompensated tonsillitis, systemic lupus erythematosus, and 20 essentially healthy subjects. In inactive rheumatism an increase in the killer activity of lymphocytes and augmentation of amounts of Fc+lymphocytes were revealed, which values were significantly different from those in the other groups. The detected changes in the activity of lymphocytes may serve as differential-diagnostic criteria.

[The activity of natural and antibody-dependent leukocyte cytotoxicity in lympholeukemia and multiple myeloma]. / Aktivnost' estestvennoi i antitelozavisimoi tsitotoksichnosti leikotsitov pri limfoleikoze i mielomnoi bolezni.

A study was made of cytotoxic activity of lymphocytes and neutrophils in the peripheral blood of 16 patients with advanced stage Kahler's disease, 4 patients in terminal stage, 14 patients with advanced stage chronic lymphoid leukosis, and 6 patients in the terminal stage disease. It has been shown that the level of cytotoxic activity of leucocytes in tumor diseases on the immunity B-system is a criterion for the extent to which the tumor process has been disseminated.