[Hyperbaric oxygenation and antianginal preparations: the effect of a single combined use on the functional indices of the state of the heart in patients with angina pectoris]. / Giperbaricheskaia oksigenatsiia i antianginal'nye preparaty: vliianie odnokratnogo sochetannogo primeneniia na pokazateli funktsional'nogo sostoianiia serdtsa u bol'nykh stenokardiei.

Using electrocardiographic technique, the effect of a single hyperbaric oxygenation session (O2 pressure 1.5 atm, duration 40 min) in combination with antianginal drugs (nifedipine--20 mg, propranolol--40 mg, nitrong--6.5 mg, orally) on central hemodynamics and myocardial contractility has been studied in 35 patients with ischemic heart disease and angina pectoris of effort, NYHA functional class II-III. It has been shown that hyperbaric oxygenation reduced the degree of indirect hemodynamic effect of nifedipine, potentiated negative chronotropic and inotropic effects of propranolol and had no impact on the degree of hemodynamic effect of depot-glycerol trinitrate.

[Interaction of hyperbaric oxygenation with nifedipine and propranolol at the level of autonomic regulation of the heart in patients with angina pectoris]. / Vzaimodeistvie giperbaricheskoi oksigenatsii s nifedipinom i propranolonom na urovne vegetativnoi reguliatsii serdtsa u bol'nykh so stenokardiei.

Thirty three males suffering from coronary heart disease, Functional Classes II-III exercise-induced angina pectoris were examined for changes occurred in autonomic cardiac regulatory parameters under the influence of a normobaric oxygenation session (control), a hyperbaric oxygenation session (oxygen pressure 1.5 atm, duration 40 min), and combined normo- and hyperbaric oxygenation with nifedipine (oral corinfar, 20 mg, n = 18), and propranolol (oral inderal, 40 mg, n = 15) sessions. Variation of pulse and statistical analysis of cardiac rhythm were used in the study. The baseline autonomic tone and autonomic provision isometric exercise were evaluated. A single hyperbaric oxygenation session in this mode during isometric exercise was shown to diminish the sympathetic activation and increased heart rate which had been caused by nifedipine, by decreasing its central sympathetic effect and increasing neuroeffector cholinergic activity. The hyperbaric oxygenation session in combination with propranolol induced a supplementary reduction in sympathetic activity and its effects on cardiac rhythm via the humoral regulatory pathway by potentiating the negative chronotropic effect of the drug.

[Effect of hyperbaric oxygenation on central hemodynamics and oxygenating function of the lungs in open-heart surgery]. / Vliianie giperbaricheskoi oksiganatsii na tsentral'nuiu gemodinamiku i oksigeniruiushchuiu funktsiiu legkikh pri operatsiiakh na otkrytom serdtse.

The dynamics of some oxygenating pulmonary function (OPF) indices has been studied in 33 patients with coronary cardiac disease and rheumatic lesions of cardiac valves 4-6 hours after surgery in response to a single hyperbaric oxygenation (HBO) session (1.5 ata, 45 min) in the immediate postoperative period. It is found that in the presence of slight or, on the contrary, pronounced arterial hypoxemia, no significant negative OPF changes were observed. At the same time, a temporary increase in the alveolo-arterial gradient has been found in some patients. The comparison of data on the systemic blood flow with the OPF indices permits suggesting the prevalent role of the membrane component in a PaO2 decrease in patients after using assisted circulation.

Changes in the properties of plasma fibronectin in Shigella-induced endotoxaemia and the responses to hyperbaric oxygenation and indomethacin.

In rabbits, Shigella endotoxin causes hypoxaemia, metabolic acidosis, and hypocapnia. These changes are more marked at a dose of 1 mg kg-1 than with one of 0.5 mg kg-1 body weight. The endotoxin also reduces the plasma level and heparin-binding activity of fibronectin (FN). During convalescence, FN activity recovers at a slower rate than its level. Hyperbaric oxygenation (HBO; 2 atm for 1 h) normalizes blood gas composition and acid-base and electrolyte balance, improves the clinical picture of endotoxaemia, enhances FN activity and, to a lesser degree, its concentration, and lowers mortality. Indomethacin (IN) (5 mg kg-1 orally) has a similar action. When HBO and IN are used in combination, there is no enhancement of the therapeutic effect and mortality increases.

[The role of hyperbaric oxygenation in the complex treatment of patients with type 1 diabetes mellitus]. / Rol' giperbaricheskoi oksigenatsii v kompleksnom lechenii bol'nykh sakharnym diabetom 1 tipa.

The results of management of decompensated type I diabetes patients were evaluated. The first group (152 patients), in addition to the traditional therapy (diet No. 9, insulin), underwent hyperbaric oxygenation (10-15 sessions, 60 min exposure at 1.7 ATA). The second group (137 patients) underwent traditional therapy. The treatments' efficacy was compared according to the indices of the hormonal status, blood gas, cell metabolism, oxygen transport function of erythrocytes, and microcirculation status. The application of HBO in the complex management of severe DM allowed for early (12-19th day) compensation of carbohydrate metabolism, reduction of anti-insulin hormone level and of the total secretory activity of the sympathoadrenal system, stimulation of the residual pancreatic beta-cell function, and insulin dose reduction. HBO facilitated normalization of blood gas content, improvement of cell metabolism, oxygen transport, and microcirculation status. The traditional therapy resulted in less pronounced (or absent) positive changes in these indices which were manifest on the 25-27th day of treatment.

[Characteristics of the antihypoxic action of piracetam]. / Osobennosti protivogipoksicheskogo deistviia piratsetama.

Pyracetam was found to inhibit free-radical lipid peroxidation, slow oxygen consumption in the liver mitochondria and increase hemoglobin oxygen-binding properties. It is assumed that the ability of pyracetam to inhibit lipid peroxidation is a mechanism which determines its antihypoxic effect.

[Effect of hyperbaric oxygenation on the extrasystole in ischemic heart disease patients]. / Vliianie giperbaricheskoi oksigenatsii na ékstrasistoliiu u bol'nykh ishemicheskoi bolezn'iu serdtsa.

A study of the effect of hyperbaric oxygenation (HBO), applied as single sessions or a treatment course, on cardiac rhythm in 82 coronary patients with chronic extrasystole demonstrated positive therapeutic effect to be achieved after the first 5 or 6 HBO sessions in all patients. Further treatment may provoke an aggravation of arrhythmia in some patients. Positive antiarrhythmic effect of a complete HBO course is doubtful, where ectopic activity is increased following the 7th session. There is a correlation between the results of ECG monitoring from the hyperbaric chamber, from session 7 onwards, and 24-hour ECG recording before and after a HBO course. As shown by 24-hour ECG monitoring, positive effect was obtained in 67% of patients with ventricular extrasystole, the number of ventricular extrasystoles remained basically unchanged after a HBO course in 17%, and ectopic activity increased in 15.4%.

[Superoxide dismutase inhibition as a prerequisite for disordered myocardial function under oxygen loading]. / Ingibirovanie superoksiddismutazy kak predposylka narusheniia funktsii miokarda pri kislorodnoi nagruzke.

Changes in the contractility of rabbit myocardium following administration of diethyl dithiocarbamate were studied to determine the role of superoxide dismutase (SOD) in cardiac support function. It was observed that in healthy rabbits, a 50% decrease in the left ventricle SOD level induced by the inhibitor was not followed by any considerable disturbances in myocardial contractility as determined without additional stimulation and load. HBO sessions caused appreciable disorders in heart contractility which could be partly prevented by SOD administration. In rabbits with adrenaline-induced heart lesions, depression of myocardial contractility induced by the inhibitor alone or in combination with intensive oxygenation was also observed.

[Characteristics of the chemiluminescence of the system containing H202 in the presence of iron compounds]. / Osobennosti khemiliuminestsentsii sistemy, soderzhashchei H202 v prisutstvii soedinenii zheleza.

The relative effectiveness of radical formation by different concentrations of hemoglobin, hemin and Fe2+ in the reaction with H2O2 evaluated by the intensity of chemiluminescence was studied. Hemoglobin was shown to be remarkably effective at the concentrations close to those in blood plasma. It is suggested that exoerythrocyte hemoglobin and the products of its destruction up to hemin are the most effective prooxidants and potential centers of radical formation in the blood.