Desaparición simultánea de nevus en un paciente con procesos autoinmunes asociados / Simultaneous Disappearance of Various Nevi in a Patient with Autoimmune Disorders

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Actualización en la dermatitis de contacto alérgica por parafenilendiamina / Allergic Contact Dermatitis Due to Paraphenylenediamine: An Update

La parafenilendiamina (PPD) es una amina empleada en la actualidad principalmente como componente de tintes capilares y en tatuajes de henna. Se ha observado un incremento en la incidencia de la dermatitis alérgica de contacto por PPD, y en edades cada vez más tempranas. En el presente trabajo se realiza una revisión de las principales fuentes que contienen PPD, así como de las sustancias con las que puede interaccionar, y se propone un algoritmo de manejo diagnóstico y terapéutico desde un enfoque práctico, para los pacientes que presenten una clínica compatible con sospecha de alergia a PPD

Paraphenylenediamine (PPD) is an amine that is mainly used as an ingredient in hair dyes and henna tattoos. The incidence of allergic contact dermatitis to PPD is increasing, particularly in younger patients. In this article, we review the main sources of PPD and the substances with which it can interact and present a practical algorithm for diagnosing and treating suspected cases of PPD allergy

Ampliando el perfil genético del síndrome de Hay-Wells / Expanding the genetic profile of Hay-Wells síndrome

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Allergic Contact Dermatitis Due to Paraphenylenediamine: An Update. / Actualización en la dermatitis de contacto alérgica por parafenilendiamina.

Paraphenylenediamine (PPD) is an amine that is mainly used as an ingredient in hair dyes and henna tattoos. The incidence of allergic contact dermatitis to PPD is increasing, particularly in younger patients. In this article, we review the main sources of PPD and the substances with which it can interact and present a practical algorithm for diagnosing and treating suspected cases of PPD allergy.

Atopic Dermatitis in Adults: A Diagnostic Challenge.

Atopic dermatitis (AD) has a prevalence of 1%-3% in adults. Adult-onset AD has only been defined recently, and lack of familiarity with this condition and confusion regarding the appropriate terminology persist. AD may first appear in childhood or de novo in adults and is characterized by pronounced clinical heterogeneity. The disease often deviates from the classic pattern of flexural dermatitis, and there are forms of presentation that are specific to adults, such as head-and-neck dermatitis, chronic eczema of the hands, multiple areas of lichenification, or prurigo lesions. Although diagnosis is clinical, adult-onset AD frequently does not fit the traditional diagnostic criteria for the disease, which were developed for children. Thus, AD is often a diagnosis of exclusion, especially in de novo cases. Additional diagnostic tests, such as the patch test, prick test, skin biopsy, or blood test, are usually necessary to rule out other diseases or other types of eczema appearing concomitantly with AD. This article presents an update of the different forms of clinical presentation for AD in adults along with a proposed diagnostic approach, as new treatments will appear in the near future and many patients will not be able to benefit from them unless they are properly diagnosed.

Reply to 'Adult atopic dermatitis: less certainty, more challenges'

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Atopic dermatitis in adults: a diagnostic challenge

Atopic dermatitis (AD) has a prevalence of 1%-3% in adults. Adult-onset AD has only been defined recently, and lack of familiarity with this condition and confusion regarding the appropriate terminology persist. AD may first appear in childhood or de novo in adults and is characterized by pronounced clinical heterogeneity. The disease often deviates from the classic pattern of flexural dermatitis, and there are forms of presentation that are specific to adults, such as head-and-neck dermatitis, chronic eczema of the hands, multiple areas of lichenification, or prurigo lesions. Although diagnosis is clinical, adult-onset AD frequently does not fit the traditional diagnostic criteria for the disease, which were developed for children. Thus, AD is often a diagnosis of exclusion, especially in de novo cases. Additional diagnostic tests, such as the patch test, prick test, skin biopsy, or blood test, are usually necessary to rule out other diseases or other types of eczema appearing concomitantly with AD. This article presents an update of the different forms of clinical presentation for AD in adults along with a proposed diagnostic approach, as new treatments will appear in the near future and many patients will not be able to benefit from them unless they are properly diagnosed (AU)

La dermatitis atópica (DA) en el adulto tiene una prevalencia del 1-3%. Es una entidad de reciente acuñamiento, que no todo el mundo conoce y sobre la que existe una gran confusión terminológica. Puede iniciarse en la infancia o presentarse de «novo» en el adulto. Presenta una gran heterogeneidad clínica y con frecuencia no sigue el patrón clásico de dermatitis flexural. Además, existen formas de presentación más propias de adulto como son la dermatitis de la cabeza y el cuello, eczema crónico de manos, áreas de liquenificación múltiple o lesiones de prurigo. Aunque su diagnóstico es clínico, muchas veces la DA del adulto no cumple los criterios diagnósticos «clásicos» de DA, pues están pensados para niños. Por eso, suele ser un diagnóstico de exclusión, sobre todo los casos de «novo». Suele precisar de la realización de pruebas diagnósticas para descartar otras enfermedades distintas u otro tipo de eczema sobreañadido a la DA. Las pruebas diagnósticas que pueden resultar útiles para ello son: pruebas epicutáneas, prick test, biopsia cutánea y una analítica sanguínea. Realizamos una actualización de las distintas formas de presentación clínica de la DA del adulto y establecemos unas pautas para llegar a su diagnóstico, pues en un futuro inmediato, con la aparición de nuevos tratamientos, muchos de estos pacientes no podrán beneficiarse de los mismos por no estar adecuadamente diagnosticados (AU)

Pseudolinfomas cutáneos / Cutaneous lymphoid hyperplasia

El término pseudolinfoma cutáneo designa proliferaciones linfoides cutáneas benignas de naturaleza reactiva que simulan linfomas cutáneos. Se trata de un término puramente descriptivo que engloba diferentes entidades reactivas, con diversa etiología, patogénesis, presentación clínica, histología y comportamiento. En el presente artículo revisaremos los distintos tipos de pseudolinfoma cutáneo. Como veremos, para llegar al correcto diagnóstico de los mismos será preciso en cada caso la integración de los datos clínicos con los histopatológicos, inmunofenotípicos y moleculares. Incluso entonces, en ocasiones solo la evolución confirmará el diagnóstico, por lo que el seguimiento será esencial

The term cutaneous pseudolymphoma refers to benign reactive lymphoid proliferations in the skin that simulate cutaneous lymphomas. It is a purely descriptive term that encompasses various reactive conditions with a varied etiology, pathogenesis, clinical presentation, histology, and behavior. We present a review of the different types of cutaneous pseudolymphoma. To reach a correct diagnosis, it is necessary to contrast clinical, histologic, immunophenotypic, and molecular findings. Even with these data, in some cases only the clinical course will confirm the diagnosis, making follow-up essential

Cutaneous Pseudolymphomas. / Pseudolinfomas cutáneos.

The term cutaneous pseudolymphoma refers to benign reactive lymphoid proliferations in the skin that simulate cutaneous lymphomas. It is a purely descriptive term that encompasses various reactive conditions with a varied etiology, pathogenesis, clinical presentation, histology, and behavior. We present a review of the different types of cutaneous pseudolymphoma. To reach a correct diagnosis, it is necessary to contrast clinical, histologic, immunophenotypic, and molecular findings. Even with these data, in some cases only the clinical course will confirm the diagnosis, making follow-up essential.