RESUMEN
Masitinib mesylate is a tyrosine kinase inhibitor approved for the treatment of gross, non-metastatic grade II and III canine mast cell tumours (MCTs). This study evaluated the use of masitinib as a frontline and rescue agent for metastatic and non-metastatic canine MCTs. Identification of toxicities and prognostic factors in these dogs was of secondary interest. Twenty-six dogs were included in this study. The overall response rate to masitinib was 50%. The median survival time for dogs that responded to masitinib was 630 days versus 137 days for dogs that did not respond (P = 0.0033). Toxicity was recorded in 61.5% of treated dogs, but the majority of adverse events were mild and self-limiting. Response to masitinib, not tumour grade, stage or location, was the most significant prognostic factor for survival in dogs with MCTs.
Asunto(s)
Enfermedades de los Perros/tratamiento farmacológico , Mastocitosis Cutánea/veterinaria , Inhibidores de Proteínas Quinasas/uso terapéutico , Neoplasias Cutáneas/veterinaria , Tiazoles/uso terapéutico , Animales , Benzamidas , Supervivencia sin Enfermedad , Perros , Femenino , Estimación de Kaplan-Meier , Masculino , Mastocitosis Cutánea/tratamiento farmacológico , Estadificación de Neoplasias , Piperidinas , Inhibidores de Proteínas Quinasas/farmacología , Piridinas , Facultades de Medicina Veterinaria , Neoplasias Cutáneas/tratamiento farmacológico , Tennessee , Tiazoles/farmacologíaRESUMEN
When observed in their home cages, cats fed commercial tuna fish cat food were less active, vocalized less, and spent more time on the floor and more time eating than cats fed commercial beef cat food. There were no differences in response to human handling between the two groups. There were no differences in learning ability on a two-choice point maze or in reversal learning in the same maze between beef- and tuna-fed cats. The behavior of the groups differed in a 15-min open field test only in the number of toys contacted. Cats fed the tuna had elevated tissue levels of mercury and selenium.