RESUMEN
Traditional light sources cannot emit an electromagnetic (EM) field with an orbital angular momentum (OAM), limiting their applications in modern optics. The recent development of the OAM laser, mainly based on micro- and nanostructures, can satisfy the increasing requirements for on-chip photonics and information capacities. Nevertheless, the photonic structures have fixed parameters that prevent these OAM lasers from being dynamically tuned. Here, we propose tunable vortex lasing from a microring cavity integrated by a phase change material, Ge2Sb2Te5 (GST225). By modulating the complex refractive index to create an exceptional point (EP) to break the degeneracy of whispering gallery modes with opposite orientations, the microlaser working at the EP can impart an artificial angular momentum, thus emitting vortex beams with well-defined OAM. The grating scatter on the edge of the microring can provide efficient vertical radiation. The vortex laser wavelength from the GST225/InGaAsP dual-layered microring cavity can be dynamically tuned by switching the state of GST225 between amorphous and crystalline without changing the microring geometry. We construct an electric-thermal model to show the tuning range of operating wavelengths (EPs) from 1544.5 to 1565.9 nm in ~25 ns. Our study on high-speed tunable PT-symmetry vortex lasers facilitates the next generation of integrated optoelectronic devices for optical computing and communications in both classical and quantum regions.
RESUMEN
A mastitis model in rats, induced by Staphylococcus aureus infection, was established and the protective effect of CpG-DNA on this model was determined. A S. aureus suspension containing 2 x 10(3) CFU.mL(-1) (SL group), 2 x 10(5) CFU.mL(-1) (SH group) or 100 microL PBS (CON group) was inoculated into the mammary glands of rats 72 h after parturition. The rats were euthanized at 24 h post-infection. The histopathologic changes in mammary tissue from SL were mild, whereas the structural changes of the mammary gland from SH were severe and polymorphonuclear leukocytes (PMNs) accumulated in mammary alveoli. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and N-acetyl-beta-d-Glucosaminidase (NAGase) in mammary tissue from SH were significantly increased, however, those from SL were not significantly changed. Therefore, 2 x 10(5) CFU.mL(-1) was selected to test the potential protective effect of CpG-DNA on mammary glands. CpG-DNA (200 microg) or PBS (100 microL) controls were intramuscularly injected right after parturition of rats. At 72 h post-partum, 2 x 10(5) CFU.mL(-1)of S. aureus (100 microL) were inoculated into the mammary gland of all rats and at pre-infection (0 h), 8, 16, 24, 48 and 72 h after inoculation six rats were euthanatized. CpG-DNA induced more rapid migration of PMNs from blood to mammary tissue at the initial stage of infection, stimulated the secretion of IL-6 and TNF-alpha at different time points, reduced viable S. aureus in mammary tissue and decreased the activity of NAGase. CpG-DNA also promoted the expression of its specific receptor TLR-9 mRNA in mammary tissue. In conclusion, CpG-DNA protected against S. aureus mastitis in a rat model.