We report the clinical and histologic features of 2 cutaneous tumors demonstrating many of the usual features of sclerotic fibroma, an entity that is well described in the literature. Our cases differed from the usual form of sclerotic fibroma in that they demonstrated marked focal cellular pleomorphism without increased mitotic activity. We suggest the term pleomorphic sclerotic fibroma for these lesions.
Fibroma/pathology , Skin Neoplasms/pathology , Actins/analysis , Female , Fibroma/metabolism , Hand , Humans , Immunohistochemistry , Middle Aged , Proliferating Cell Nuclear Antigen/analysis , Skin/chemistry , Skin/pathology , Skin Neoplasms/metabolism
We report a 73-year-old woman presenting with recurrent eruptions of generalized follicular pustules. Histological examination revealed several palisading necrobiotic granulomas with mucin deposits, with a perifollicular distribution. A dense neutrophilic infiltrate in the upper portion of affected follicular structures gave rise to pustulous lesions. Scaly papules and pseudovesiculous lesions over the palms with deeper necrobiotic granulomas involving sweat glands and epidermal perforation coexisted in some of the eruptions with generalized pustules. We propose the term follicular pustulous granuloma annulare for this peculiar form of granuloma annulare, which widens the clinicopathological spectrum of presentation of this disease.
Granuloma Annulare/pathology , Aged , Anti-Inflammatory Agents/therapeutic use , Female , Granuloma Annulare/drug therapy , Hair Follicle/pathology , Humans , Prednisone/therapeutic use
