Neuropsychiatric Adverse Effects of Trimethoprim-Sulfamethoxazole: A Rare Case of Acute Psychosis in an Immunocompetent Patient.

Trimethoprim-sulfamethoxazole (TMP-SMX) is a combination of two antibiotics used to treat various bacterial infections, generally well-tolerated but can rarely cause neuropsychological adverse effects, including psychosis. This case report describes a 69-year-old immunocompetent female who developed acute visual and auditory hallucinations three days after starting TMP-SMX for a urinary tract infection (UTI). The patient had a history of depression, successfully treated with mirtazapine a decade ago, and no other psychiatric or medical conditions. Laboratory tests and imaging were unremarkable. Symptoms resolved completely within two days of discontinuing TMP-SMX, suggesting a causal relationship. This case highlights the need for vigilance regarding the neuropsychiatric side effects of TMP-SMX, even in immunocompetent individuals, and underscores the importance of considering medication-induced psychosis in differential diagnoses. Further research is warranted to elucidate the mechanisms underlying this adverse drug reaction.

Clinical Reasoning and Challenges Faced With Onset Psychotic Symptoms in a Case of Combined Huntington's Disease and Gayet-Wernicke Encephalopathy.

Physicians are occasionally confronted with patients presenting psychotic symptoms of organic origin. Therefore, precision in diagnosing the organic basis is pivotal for targeted treatment, addressing the underlying etiology. This case study delineates the nuanced phases of clinical reasoning employed to ascertain a diagnosis of Huntington's disease (HD), notably amidst concurrent alcohol dependence. A comprehensive clinical examination and meticulous review of the patient's medical history served as linchpins in guiding subsequent investigations toward identifying the etiological underpinnings of the psychotic symptomatology. Furthermore, this case sheds light on the uncommon overlap of HD and Wernicke's encephalopathy, compounding diagnostic complexities, especially given the polymorphic nature of HD. The diagnostic intricacies needed precise analysis of the clinical picture and a deep understanding of potential interactions between neurological pathologies and the deleterious effects of alcoholism on the nervous system.

Psychological Outcomes and Quality of Life After Hysterectomy for Benign Diseases: A Prospective Cohort Study.

Background Hysterectomy is a common surgical procedure performed for benign gynecological diseases. While the physical benefits have been extensively studied, less attention has been given to its impact on psychological well-being and overall quality of life (QoL). This study aimed to assess the psychological outcomes and QoL before and after hysterectomy for benign diseases. Methodology This prospective cohort study included women undergoing hysterectomy for benign diseases at Ibn El Jazzar Hospital in Kairouan, Tunisia. The study was conducted from January 2, 2020, to December 31, 2021. We used the Short-Form-36 Health Survey (SF-36) to evaluate the QoL and the Hospital Anxiety and Depression Scale (HADS) to assess psychological outcomes preoperatively and after six months. Data entry and analysis were performed using SPSS version 26 (IBM Corp., Armonk, NY, USA) with the significance level (p) set to 0.05. Results Of 84 assessed patients, 60 were included. Following the hysterectomy, there were improvements in QoL and psychological outcomes across all domains, regardless of whether total or subtotal hysterectomy was performed. The mean HADS score for anxiety decreased from 12.57 to 8.77 after hysterectomy and from 14.83 to 9.57 for depression. Moreover, the median SF-36 total score increased from 29.81 to 68.1. We found no statistically significant difference between the two groups in all assessed outcomes. Conclusions Hysterectomy for benign conditions, whether total or subtotal, positively impacted symptoms of depression and anxiety, as well as the overall QoL for patients. A thorough preoperative psychiatric assessment is recommended to address and support mental health outcomes in these patients. Future research should consider a larger multicenter approach for a broader application of findings.

Myxedema Psychosis: Diagnostic Challenges and Management Strategies in Hypothyroidism-Induced Psychosis.

Myxedema psychosis (MP), a rare psychiatric manifestation of hypothyroidism, presents significant diagnostic and therapeutic challenges. This case report details the presentation, diagnosis, and successful management of a 60-year-old woman with MP, who was initially admitted to the psychiatric department for new-onset psychosis following the cessation of hormone replacement therapy after a subtotal thyroidectomy performed 20 years prior. Despite the rarity of psychosis as an initial presentation of hypothyroidism, this case underscores the critical importance of considering endocrine disorders in the differential diagnosis of unexplained psychotic symptoms. The clinical findings included a polymorphic delusional system and auditory hallucinations, without significant abnormalities on magnetic resonance imaging. Elevated thyroid-stimulating hormone (TSH) levels confirmed hypothyroidism, leading to the diagnosis of MP. Treatment with l-thyroxine resulted in complete resolution of symptoms in three weeks, highlighting the efficacy of hormone replacement therapy. This case contributes to the limited literature on MP and echoes the need for awareness among clinicians to ensure timely and accurate diagnosis and treatment.

Body Image Misperceptions Among Tunisian Adolescents.

Background Obesity is a globally recognized health concern with profound consequences for individual health, especially among adolescents. Tunisia, like many countries, is experiencing alarming rates of adolescent obesity. Understanding adolescents' perceptions of their weight status and the factors influencing these perceptions is pivotal for developing targeted interventions and policies to counteract the rising obesity trends. Objective To determine the accuracy of weight status perceptions among Tunisian adolescents compared to objective metrics and to identify sociodemographic characteristics associated with the inaccurate estimation of weight status. Methods A cross-sectional, school-based study was conducted among adolescents attending secondary schools in Sousse, Tunisia, during the 2017-2018 academic year. A total of 1399 students participated, with anthropometric measurements taken, and a pre-tested Arabic questionnaire administered to gather sociodemographic data and perceived weight status, assessed using the Figure Rating Scale (FRS). The accuracy of perceived weight status was determined by comparing the measured weight status with participants' self-reported perceptions. Results The study achieved an 86.68% response rate, with over half of the participants being female (60.5%), and the average age being 17 years. The majority of adolescents (41%) perceived themselves as having normal body weight, while 34.5% perceived themselves as underweight, 16.6% as overweight, and 7.9% as obese. However, based on BMI categories, 72.6% had a normal measured weight, 20.4% were overweight, and 6.9% were obese. A substantial proportion of participants (45.6%) underestimated their weight status, with a significant proportion being objectively overweight or obese (26%). Furthermore, we found a significant association between the perception of weight accuracy and both gender (p = 0.010) and the mother's educational level (p = 0.035). Conclusions The findings revealed a disparity between perceived and actual weight status among Tunisian adolescents, with a significant underestimation of weight status, particularly among those who are overweight or obese. The results highlighted the crucial need for interventions that address weight perception inaccuracies and promote healthy weight awareness and management among adolescents in Tunisia.

Clitoral Abscess: A Case Report Highlighting an Uncommon Source of Gynecological Emergency.

Clitoral abscess is a rare gynecological condition with limited literature reports. This case report aimed to contribute to the understanding and management of clitoral abscesses, particularly in cases without identifiable causes. A 26-year-old sexually active woman with no significant medical history presented with severe perineal pain originating specifically in the clitoral region. The onset of symptoms, characterized by pulsatile perineal pain worsening over several days, was localized to the clitoris. Clinical examination indicated a clitoral abscess, confirmed through surgical incision and drainage. The medical treatment consisted of the administration of oral analgesics, flucloxacillin at a dose of 500 mg for seven days, and non-steroidal anti-inflammatory agents. The procedure preserved the dorsal artery of the clitoris, with bacteriological analysis revealing polymicrobial organisms. Post surgery, the patient recovered fully with no complications. By sharing details about this unusual clinical case and its effective treatment, we contribute to advancing the collective knowledge in the field. This dissemination supports a deeper understanding and facilitates informed decision-making for healthcare professionals.

Focal epilepsy and psychosis symptoms: A case report and review of the literature.

Background: Epilepsy is still a real mental health problem; although most epilepsies are curable, their psychopathological consequences are often significant and complex to manage. In this framework, the association of epilepsy with psychotic disorders has long been known. Case presentation: To discuss the links between epilepsy and psychosis, we report the observation of a 52-year-old man, treated for complex focal epilepsy, admitted to a psychiatric department for auditory and visual hallucinations and a behavioural disorder not improved by antiepileptic treatment alone or an antipsychotic alone. Discussion: Psychotic symptoms in epilepsy can be part of intercritical, post-critical or alternative psychoses. In our patient's case, the psychotic symptoms were post-critical and alternative. It was probably an associated schizophreniform disorder. Emotional indifference and activity restriction are rarely encountered in this setting, while rapid mood fluctuations are frequent. Delusional themes are often mystical, fueled by auditory and unusual visual hallucinations. Negative disorders are rare. Conclusion: Epileptic psychoses have not been identified as nosographic entities in the psychiatric classification systems (DSM-V and ICD-10), which poses a problem in recognizing these disorders. Therefore, a collaboration between psychiatrists and neurologists is necessary to understand this complex comorbidity better, avoid diagnostic errors, and optimize management.