What's going on with teleworking? a scoping review of its effects on well-being.

Studies of teleworking and well-being increased dramatically during the COVID-19 pandemic. This article aims to provide an overview of this emerging body of knowledge. Following the PRISMA guidelines, we performed a scoping review using Social Sciences Citation Index (Web of Science), Sociological Abstracts (PROQUEST), and SocINDEX with full text (EBSCOhost). Articles published in English up to December 2022 were included. The result was a total of 2695 potentially relevant studies. After a double-screening procedure, 132 studies were chosen for data extraction. A content analysis was carried out to provide a summary of the social mechanisms linking teleworking to indicators of well-being related to mental health and quality of life. A complex picture of variables emerges on the impact of teleworking through direct or indirect mechanisms and a number of interactions with worker's characteristics. First, the features of the environment matter, as it affects well-being, for example, depending on a better digital infrastructure, access to daylight and sufficient space. Second, it is not only a question of "where" we telework, but also "how much". The advantages of a hybrid mode seem to be emerging to avoid an excessive lack of in-person social interaction, while offering greater flexibility in organizing daily life and reducing commuting times. Third, beyond the modalities of teleworking per se, it is key to take into account how these interact with workers' personalities, their choices and preferences, which are often dictated by the stage of life they are in, e.g., parenting and career stages. In sum, the literature suggests that a straight answer on the positive or negative effects of teleworking is neither useful nor necessary. Multiple answers are possible to unveil the specific working arrangements that makes workers' lives better according to their different needs. It seems essential to continue research on teleworking away from the exceptional stressors of the COVID-19 pandemic, which have greatly skewed the evidence on the detrimental effects of teleworking. Planning more complex research designs using longitudinal data and network analyses could improve understanding of how teleworking is changing careers, lifestyles and social relationships.

Prevalence of and risk factors for suicidal ideation in adolescents during the COVID-19 pandemic: a cross-sectional study.

BACKGROUND AND OBJECTIVES: Pandemic-related life changes may have had a deleterious impact on suicidal behaviours. Early detection of suicidal ideation and identification of subgroups at increased risk could help prevent suicide, one of the leading causes of death among adolescents worldwide. Here, we aimed to investigate the prevalence of and risk factors for suicidal ideation in adolescents using a population-based sample from Switzerland, two years into the pandemic. METHODS: Between December 2021 and June 2022, adolescents aged 14 to 17 years already enrolled in a population-based cohort study (State of Geneva, Switzerland) were asked about suicidal ideation over the previous year. In addition to a regression model, we conducted a network analysis of exposures which identified direct and indirect risk factors for suicidal ideation (i.e. those connected through intermediate risk factors) using mixed graphical models. RESULTS: Among 492 adolescents, 14.4% (95% CI: 11.5-17.8) declared having experienced suicidal ideation over the previous year. Using network analysis, we found that high psychological distress, low self-esteem, identifying as lesbian, gay or bisexual, suffering from bullying, extensive screen time and a severe COVID-19 pandemic impact were major risk factors for suicidal ideation, with parent-adolescent relationship having the highest centrality strength in the network. CONCLUSION: Our results show that a significant proportion of adolescents experience suicidal ideation, yet these rates are comparable with pre-pandemic results. Providing psychological support is fundamental, with a focus on improving parent-adolescent relationships.

JAK/STAT autocontrol of ligand-producing cell number through apoptosis.

During development, specific cells are eliminated by apoptosis to ensure that the correct number of cells is integrated in a given tissue or structure. How the apoptosis machinery is activated selectively in vivo in the context of a developing tissue is still poorly understood. In the Drosophila ovary, specialised follicle cells [polar cells (PCs)] are produced in excess during early oogenesis and reduced by apoptosis to exactly two cells per follicle extremity. PCs act as an organising centre during follicle maturation as they are the only source of the JAK/STAT pathway ligand Unpaired (Upd), the morphogen activity of which instructs distinct follicle cell fates. Here we show that reduction of Upd levels leads to prolonged survival of supernumerary PCs, downregulation of the pro-apoptotic factor Hid, upregulation of the anti-apoptotic factor Diap1 and inhibition of caspase activity. Upd-mediated activation of the JAK/STAT pathway occurs in PCs themselves, as well as in adjacent terminal follicle and interfollicular stalk cells, and inhibition of JAK/STAT signalling in any one of these cell populations protects PCs from apoptosis. Thus, a Stat-dependent unidentified relay signal is necessary for inducing supernumerary PC death. Finally, blocking apoptosis of PCs leads to specification of excess adjacent border cells via excessive Upd signalling. Our results therefore show that Upd and JAK/STAT signalling induce apoptosis of supernumerary PCs to control the size of the PC organising centre and thereby produce appropriate levels of Upd. This is the first example linking this highly conserved signalling pathway with developmental apoptosis in Drosophila.