The mediation effect of treatment fatigue in the association between memory and health-related quality of life in men with HIV who have sex with men.

Approximately half of all adults living with the Human Immunodeficiency Virus (HIV) experience cognitive alterations related to difficulties in treatment adherence and, therefore, to a significant decrease in quality of life. In this sense, new studies are needed to identify potential mediators related to treatment in this association, such as treatment fatigue. This fact is especially important in at specific groups of individuals with HIV, namely men with HIV who have sex with men (MSM). The objective of this study was to analyze the association between cognitive functioning, Health-Related Quality of Life (HRQoL), and treatment fatigue in MSM with HIV. A cross-sectional study was developed with a sample of 70 MSM, from the Infectious Diseases Unit of the General University Hospital of Alicante (Spain). Participants completed questionnaires related to sociodemographic data, HRQoL, and treatment fatigue in an initial phase; in a second phase, they were administered a computerized cognitive evaluation. Our results demonstrate a significant relationship between a lower cognitive performance in the memory domain and worse HRQoL. Mediation analysis has revealed the total mediation effect of treatment fatigue, specifically, the treatment cynicism domain, on this relationship. This mediation effect remained significant after controlling the sociodemographic and clinical HIV-related variables in the model. No significant mediation effects of the rest of evaluated cognitive domains (attention, perception, reasoning, or coordination) were found in this relationship. The results of this study highlight how MSM with a significant deterioration of memory are at greater risk of developing high levels of treatment fatigue, and, therefore, a lower adherence to the same and a significant deterioration in their HRQoL.

Lights4Violence: a quasi-experimental educational intervention in six European countries to promote positive relationships among adolescents.

BACKGROUND: Preventing intimate partner violence or dating violence (DV) among adolescents is a public health priority due to its magnitude and damaging short and long-term consequences for adolescent and adult health. In our study protocol, we complement prior experiences in DV prevention by promoting protective factors (or assets) against gender violence such as communication skills, empathy and problem-solving capability through "Cinema Voice", a participatory educational intervention based on adolescents' strengths to tackle DV. METHODS/DESIGN: A longitudinal quasi-experimental educational intervention addressed to boys and girls ages 13-17 years, enrolled in secondary education schools in Alicante (Spain), Rome (Italy), Cardiff (UK), Iasi (Romania), Poznan (Poland) and Matosinhos (Portugal). Both process and results evaluations will be carried out with 100-120 intervention and 120-150 control group students per city at three time periods: before, after and 6 months after the implementation of the following interventions: 1) Training seminar with teachers to promote knowledge and skills on the core issues of intervention; 2) Workshops with intervention groups, where participants produce their own digital content presenting their perspective on DV; and 3) Short film exhibitions with participants, their families, authorities and other stakeholders with the objective of share the results and engage the community. Outcome measures are self-perceived social support, machismo, sexism, tolerance towards gender violence, social problem-solving and assertiveness as well as involvement in bullying/cyberbullying. Other socio-demographic, attitudes and violence-related co-variables were also included. DISCUSSION: This study may provide relevant information about the effectiveness of educational interventions that combine a positive youth development framework with educational awareness about the importance of achieving gender equality and preventing and combating gender violence. To our knowledge, this is the first study that involves six European countries in an educational intervention to promote violence protective assets among enrolled adolescents in secondary schools. This study may provide the needed tools to replicate the experience in other contexts and other countries. TRIAL REGISTRATION: Clinicaltrials.gov: NCT03411564 . Unique Protocol ID: 776905. Date registered: 18-01-2018.

Evaluation of Mediterranean diet adherence scores: a systematic review.

OBJECTIVE: The aim of this review was to evaluate the conceptual suitability, applicability and psychometric properties of scores used internationally to measure adherence to the Mediterranean diet (MD). DESIGN: This was a systematic review to identify original articles that examined some aspects of the conceptual suitability, applicability or psychometric properties of the MD adherence score. Electronic searches were carried out on the international databases MEDLINE, Scopus, Web of Science and EMBASE (from January 1980 to 31 December 2015). ELIGIBILITY CRITERIA FOR SELECTING STUDIES: The study included original articles that examined some aspects of the conceptual suitability, applicability or psychometric properties of the MD adherence score. The studies where MD adherence scores were administered but did not bring forward any evidence about their performance related to conceptual suitability, applicability or psychometric properties were excluded. DATA EXTRACTION: Information relating to the scales was extracted in accordance with the quality criteria defined by the Scientific Advisory Committee of the Medical Outcomes Trust for measurement of health results and the quality criteria recommended by Terwee: (1) conceptual, (2) applicability and (3) psychometric properties. Three authors independently extracted information from eligible studies. RESULTS: Twenty-seven studies were identified as meeting the inclusion criteria, yielding 28 MD adherence scores. The results showed that evidence is scarce and that very few scores fulfilled the applicability parameters and psychometric quality. The scores developed by Panagiotakos et al, Buckland et al and Sotos-Prieto et al showed the highest levels of evidence. CONCLUSIONS: Scores measuring adherence to MD are useful tools for identifying the dietary patterns of a given population. However, further information is required regarding existing scores. In addition, new instruments with greater conceptual and methodological rigour should be developed and evaluated for their psychometric properties.

Relationship between Adherence to the Mediterranean Diet and Health-Related Quality of Life and Life Satisfaction among Older Adults.

OBJECTIVES: Evaluate the relationship between adherence to the Mediterranean diet and health-related quality of life and degree of life satisfaction among older adults. DESIGN AND SETTING: Cross-sectional descriptive study. PARTICIPANTS: A total of 351 people older than 60 years participated in the study. MEASUREMENTS: The Mediterranean Diet Score (MDS) was calculated to assess the degree of adherence to the MD. MD adherence was related to health-related quality of life using the Short Form Healthy Survey (SF-12) questionnaire, to life satisfaction using the Satisfaction with Life Scale (SWLS), and to sociodemographic, clinical and lifestyle variables. Multiple logistic regression models were used to analyse this relationship. RESULTS: Mediterranean diet adherence was related to health- related quality of life. Participants with better adherence to the MD were more physically active (p=0.01) and had better health-related quality of life (p<0.05) and lower consumption of alcoholic beverages (p=0.04). The age-adjusted model showed a significant association between the MD and mental function for both sexes and with physical function only for men. The fully adjusted model showed a direct relationship between the MD and life satisfaction of women (p>0.05) but not for that of men (p=0.31). CONCLUSIONS: The adherence to the MD is directly associated with the self-perceived physical and mental function of both sexes and with the life satisfaction of women. Further studies in older adult populations should be performed to obtain conclusive results on the MD effect on health-related quality of life, including wellness indicators.

Trail Making Test: Normative data for the Latin American Spanish-speaking pediatric population.

OBJECTIVE: To generate normative data for the Trail Making Test (TMT) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 3,337 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TMT as part of a larger neuropsychological battery. The TMT-A and TMT-B scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS: The final multiple linear regression models showed main effects for age on both scores, such that as children needed less time to complete the test while they become older. TMT-A scores were affected by age2 for all countries except, Cuba, Guatemala, and Puerto. TMT-B scores were affected by age2 for all countries except, Guatemala and Puerto Rico. Models indicated that children whose parent(s) had a MLPE >12 years of education needed less time to complete the test compared to children whose parent(s) had a MLPE ≤12 years for Mexico and Paraguay in TMT-A scores; and Ecuador, Mexico, Paraguay, and Spain for TMT-B scores. Sex affected TMT-A scores for Chile, Cuba, Mexico, and Peru, in that boys needed less time to complete the test than girls. Sex did not affect TMT-B scores. CONCLUSIONS: This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate approach to interpret the TMT in pediatric populations.

Newly developed Learning and Verbal Memory Test (TAMV-I): Normative data for Spanish-speaking pediatric population.

OBJECTIVE: To generate normative data for the Learning and Verbal Memory Test (TAMV-I) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the TAMV-I as part of a larger neuropsychological battery. Free recall, memory delay and recognition scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS: The final multiple linear regression models indicated main effects for age on all scores, such that scores increased linearly as a function of age. Age2 had a significant effect in all countries except Cuba, and Puerto Rico for free recall score; a significant effect for memory delay score in all countries except Cuba and Puerto Rico; and a significant effect for recognition score in in all countries except Guatemala, Honduras, and Puerto Rico. Models showed an effect for MLPE in Chile (free recall), Honduras (free recall), Mexico (free recall), Puerto Rico (free recall, memory delay, and recognition), and Spain (free recall and memory delay). Sex affected free recall score for Cuba, Ecuador, Guatemala, Mexico, Paraguay, Peru, and Spain, memory delay score for all countries except Chile, Paraguay, and Puerto Rico, and recognition score for Ecuador, Mexico, Peru, and Spain, with girls scoring higher than boys. CONCLUSIONS: This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate way to interpret the TAMV-I with pediatric populations.

Rey-Osterrieth Complex Figure - copy and immediate recall (3 minutes): Normative data for Spanish-speaking pediatric populations.

OBJECTIVE: To generate normative data for the Rey-Osterrieth Complex Figure (ROCF) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the ROCF as part of a larger neuropsychological battery. The ROCF copy and immediate recall (3 minutes) scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS: The final multiple linear regression models showed main effect for age on copy and immediate recall scores, such that scores increased linearly as a function of age. Age2 affected ROCF copy score for all countries, except Puerto Rico; and ROCF immediate recall scores for all countries, except Chile, Guatemala, Honduras, Paraguay, and Puerto Rico. Models indicated that children whose parent(s) had a MLPE >12 years obtained higher scores compared to children whose parent(s) had a MLPE≤12 years for Chile, Puerto Rico, and Spain in the ROCF copy, and Paraguay and Spain for the ROCF immediate recall. Sex affected ROCF copy and immediate recall score for Chile and Puerto Rico with girls scoring higher than boys. CONCLUSIONS: This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate approach to interpret the ROCF Test in pediatric populations.

Verbal fluency tests: Normative data for Spanish-speaking pediatric population.

OBJECTIVE: To generate normative data for the phonological and semantic verbal fluency tests (VFT) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the VFT as part of a larger neuropsychological battery. Scores for letters F, A, S, and animals and fruit categories were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS: The final multiple linear regression models showed main effects for age on all scores, such that scores increased linearly as a function of age. Age2 had a significant effect in Chile (animals), Cuba (A letter, fruits), Ecuador (animals, fruits), Honduras (F letter), Mexico (animals, fruits), Peru (fruits), and Spain (S letters, animals, fruits). Models showed an effect for MLPE in Chile (A letters, animals, fruits), Ecuador (S letter, animals, fruits), Guatelama (F, S letter, animals), Honduras (animals), Mexico (F, A, S letters, animals, fruits), Puerto Rico (A, letters, animals), and Spain (all scores). Sex scores were found significant in Chile (animals), Ecuador (A letter, fruits), Mexico (F letter, fruits), Paraguay (F, A, S letters, fruits), Puerto Rico (F letter, animals, fruits), and Spain (F letter, fruits). CONCLUSIONS: This is the largest multi-national Spanish speaking-pediatric normative study in the world, and as such it will allow neuropsychologists from these countries to have a more accurate way to interpret the phonological and semantic VFT in pediatric populations.

[Sexual function and quality of life in hemodialysis male patients]. / Función sexual y calidad de vida en pacientes varones de hemodiálisis.

BACKGROUND: The sexual dysfunction is a highly prevalent problem among uremic men that limits their quality of life. The aim of this study was to determine the sexual function in chronic renal failure in males patients on hemodialysis and to find the nature of the problem. Also, we explored the impact of sexual dysfunction on health-related quality of life. METHODS: 103 male patients older than 18 years and receiving HD treatment were studied. The sexual function was evaluated with the International Index of Erectile Function, and the health-related quality of life was quantified with the COOP-WONCA Charts, both in their Spanish versions. RESULTS: 47% of the patients didn't have any kind of sexual activity. These ones presented a more advanced age (p < 0.001), a longer stay on dialysis (p < 0.001), a greater comorbidity index (p < 0.05) and smaller levels of seric albumin (p < 0.05). The sexually active patients presented a better physical fitness (p < 0.001) and overall health (p < 0.05), and a smaller difficulty to carry out the daily activities (p < 0.05) and pain (p < 0.05). A 40% of the patients with some kind of sexual function had a good erectile function, the 34.5% suffered a slight erectile dysfunction, the 16.4% a moderate one and the 9.1% a severe one. Multiple linear regression analysis demonstrated that the main determinant of the sexual activity was the age, followed by the physical fitness and the time on HD (32.7% of the variance explained). We found statistically significative correlation between the total score of IIEF and felings (r = -0.34; p < 0.05), daily activities (r = -0.27; p < 0.05), social activities (r = -0.30; p < 0.05), social support (r = -0.45; p < 0.01) and quality of life (r = -0.29; p < 0.05). The patients without sexual activity didn't perceive their deficiency as a problem and considered this situation inherent to the ageing process. CONCLUSIONS: The sexual dysfunction is a highly prevalent problem in the uremic male, but it doesn't have to be necessarily associated to a serious deterioration of the HRQOL. In this way, the presence or not of sexual activity doesn't present significant effect on the things that one has or wants to do. With everything, the patient without sexual activity frequently has advanced age, refers worse state of health and presents more problems of physical functioning and at the moment of taking to daily activities.

Función sexual y calidad de vida en pacientes varones de hemodiálisis / Sexual function and quality of life in hemodialysis male patients

Introducción: La disfunción sexual es un síntoma altamente prevalente en lospacientes con insuficiencia renal crónica. En el presente estudio nos proponemosdeterminar la función sexual en los pacientes varones de nuestro programa de hemodiálisis(HD), identificar la naturaleza del problema en caso de disfunción yanalizar su repercusión sobre la calidad de vida relacionada con la salud (CVRS).Métodos: Para ello se estudiaron 103 varones en programa de HD crónica ennuestro Centro. La función sexual y la CVRS se determinaron mediante la cumplimentacióndel test internacional de función eréctil (IIEF) y las láminasCOOP/WONCA respectivamente.Resultados: El 47% de los pacientes carecía de actividad sexual. Estos tenían unaedad más avanzada (p < 0,001), llevaban más tiempo en diálisis (p < 0,01), teníanmayor índice de comorbilidad (p < 0,05) y menores niveles séricos de albúmina(p < 0,05) que los sexualmente activos. Los pacientes activos sexualmente teníanmejor forma física (p < 0,001), estado de salud (p < 0,05) y presentaron menor dificultadpara realizar las actividades cotidianas (p < 0,05) y dolor (p < 0,05) que lossexualmente inactivos. De acuerdo a la puntuación en función eréctil sólo el 40%carecía de problemas de impotencia, el 34,5% padecía una disfunción eréctil leve,el 16,4% moderada y el 9,1% severa. Los principales determinantes para la existenciade actividad sexual fueron la edad, la forma física y el tiempo de permanenciaen HD, explicando entre los tres el 32,7% de la varianza. Existe una correlación estadísticamentesignificativa de la puntuación global del IIEF con las láminas sentimientos(r = -0,34; p < 0,05), actividades cotidianas (r = -0,27; p < 0,05), actividadessociales (r = -0,30; p < 0,05), apoyo social (r = -0,45; p < 0,01) y calidad devida (r = -0,29; p < 0,05). Los pacientes sin actividad sexual no percibieron esta carenciacomo un problema, asimilándola dentro del proceso natural de envejecimiento.Conclusiones: Aunque la disfunción sexual es un problema altamente prevalenteentre los varones en HD, no se asocia necesariamente con un deterioro severoen la CVRS. De hecho, la presencia o no de actividad sexual no presenta efectosignificativo sobre las cosas que uno tiene o desea hacer. Con todo, el pacientesin actividad sexual suele ser mayor, refiere peor estado de salud y presenta másproblemas de funcionamiento físico y a la hora de llevar a cabo las diversas actividadesde la vida cotidiana

Background: The sexual dysfunction is a highly prevalent problem among uremicmen that limits their quality of life. The aim of this study was to determinethe sexual function in chronic renal failure in males patients on hemodialysis andto find the nature of the problem. Also, we explored the impact of sexual dysfunctionon health-related quality of life.Methods: 103 male patients older than 18 years and receiving HD treatmentwere studied. The sexual function was evaluated with the International Index ofErectile Function, and the health-related quality of life was quantified with theCOOP-WONCA Charts, both in their Spanish versions.Results: 47% of the patients didn’t have any kind of sexual activity. These onespresented a more advanced age (p < 0,001), a longer stay on dialysis (p < 0,001),a greater comorbidity index (p < 0,05) and smaller levels of seric albumin (p <0,05). The sexually active patients presented a better physical fitness (p < 0,001)and overall health (p < 0,05), and a smaller difficulty to carry out the daily activities(p < 0,05) and pain (p < 0,05). A 40% of the patients with some kind ofsexual function had a good erectile function, the 34,5% suffered a slight erectiledysfunction, the 16,4% a moderate one and the 9,1% a severe one. Multiple linearregression analysis demonstrated that the main determinant of the sexual activitywas the age, followed by the physical fitness and the time on HD (32,7%of the variance explained). We found statistically significative correlation betweenthe total score of IIEF and felings (r = -0,34; p < 0,05), daily activities (r = -0,27;p < 0,05), social activities (r = -0,30; p < 0,05), social support (r = -0,45; p <0,01) and quality of life (r = -0,29; p < 0,05). The patients without sexual activitydidn’t perceive their deficiency as a problem and considered this situation inherentto the ageing process.Conclusions: The sexual dysfunction is a highly prevalent problem in the uremicmale, but it doesn’t have to be necessarily associated to a serious deteriorationof the HRQOL. In this way, the presence or not of sexual activity doesn’t presentsignificant effect on the things that one has or wants to do. With everything,the patient without sexual activity frequently has advanzed age, refers worse stateof health and presents more problems of physical functioning and at the momentof taking to daily activities