RESUMEN
Objective: The prognostic significance of the resection margins is still subject of conflicting opinions. The purpose of this paper is to report the results of a study on the margins in carcinoma of the oral cavity, oro-hypopharynx and larynx. Methods: A multicentre prospective study was carried out between 2015 and 2018 with the participation of 10 Italian reference hospitals. The primary objective was to evaluate local control in patients with well-defined clinical characteristics and comprehensive histopathological information. Results: During the study period, 455 patients were enrolled; the minimum follow-up was 2 years. Previous treatment, grading and fresh specimen examination were identified as risk factors for local control in multivariate analysis. On the basis of these results, it seems possible to delineate "risk profiles" for different oncological outcomes. Discussion: The prognostic significance of the margins is reduced, and other risk factors emerge, which require diversified treatment and follow-up. Conclusions: Multidisciplinary treatment with adjuvant therapy, if indicated, reduces the prognostic importance of margins. Collaboration with a pathologist is an additional favourable prognostic factor and quality indicator.An appendix with literature review is present in the online version.
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Carcinoma de Células Escamosas , Laringe , Carcinoma de Células Escamosas/cirugía , Humanos , Hipofaringe/patología , Laringe/patología , Márgenes de Escisión , Boca , Recurrencia Local de Neoplasia/cirugía , Pronóstico , Estudios Prospectivos , Estudios RetrospectivosRESUMEN
OBJECTIVES: First aim of study was to compare the diagnostic accuracy of high resolution T2-WI (HRT2-WI) and gadolinium-enhanced T1-weighted image (Gd T1-WI) sequences in quantitative evaluation of vestibular schwannomas (VS). The second one was to determine through qualitative evaluation when Gd-injection should be recommended. METHODS: Two observers in consensus retrospectively reviewed 137 magnetic resonance imaging (MRI) scans of patients with histological diagnosis of VS (33 women, 26 men), 116 with both HRT2-WI and Gd T1-WI. The examinations were subdivided in: surveillance (10), pretreatment (30), posttreatment (43), and posttreatment follow-up (33) studies. Quantitative evaluation was based on size measurement of the lesion. Structural details of the lesion, facial nerve course, and involvement of the fundus of the internal auditory canal were assessed for the qualitative evaluation in both sequences. RESULTS: No statistically significant changes were demonstrated between size measurement in the HRT2-WI and Gd T1-WI (pâ=â0.329). Sensitivity, specificity, and accuracy of HRT2-WI in the detection of lesional size were 90.4, 98.9, 92.5%, respectively. HRT2-WI was worse for characterization of structural details in pretreatment, posttreatment, and posttreatment follow-up examinations. HRT2-WI showed better or equal capability for all the groups in the demonstration of the facial nerve course. In the evaluation of the involvement of the fundus of the internal auditory canal, HRT2-WI showed worse results or had a complementary role for the posttreatment and posttreatment follow-up groups, while in the other groups was considered mainly equal or complementary. Only in the surveillance group, HRT2-WI was never worse for all the criteria. CONCLUSION: Results for quantitative evaluation were similar in both the sequences. Gadolinium injection can be avoided only in surveillance studies.
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Imagen por Resonancia Magnética/métodos , Neuroimagen/métodos , Neuroma Acústico/diagnóstico por imagen , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Medios de Contraste , Femenino , Gadolinio , Humanos , Interpretación de Imagen Asistida por Computador/métodos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Sensibilidad y Especificidad , Adulto JovenRESUMEN
The objective of the present paper was to acquire information about the mastoidectomy size necessary to obtain an optimal placement of the direct acoustic cochlear implant actuator and fixation system. Ten human cadaveric temporal bones were dissected and implanted with direct acoustic cochlear implant. Mastoidectomy size was determined after implantation in each temporal bone. A bone bed for the receiver/stimulator, mastoidectomy and a large posterior tympanotomy were drilled out. The mastoidectomy was progressively enlarged posteriorly in small steps until the actuator template was judged adequately oriented to enable passage of the rod through the posterior tympanotomy without any contact with the bony walls. The distance between different landmarks in the mastoidectomy was measured. All measured values showed a high degree of consistency, with limited median absolute deviation values. One of the most critical measure, i.e. the distance between the posterior margin of the mastoidectomy to the superior rim of the bony external ear canal wall, ranged from 13 to 16 mm with a median value of 15 mm. Prior knowledge of the ideal size of the mastoidectomy for direct acoustic cochlear implant facilitates the positioning of the fixation system and may save time during implant surgery.
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Implantación Coclear/métodos , Apófisis Mastoides , Implantes Cocleares , Humanos , Apófisis Mastoides/patología , Apófisis Mastoides/cirugía , Modelos Anatómicos , Tamaño de los Órganos , Retención de la Prótesis/métodos , Hueso Temporal/patología , Hueso Temporal/cirugíaRESUMEN
A 40-year-old man presented with conductive hearing loss and pressure- and sound-related vestibular symptoms. Computed tomography and diffusion-weighted magnetic resonance imaging revealed the presence of a cholesteatoma involving the vestibular labyrinth. The patient underwent a canal-wall-up tympanoplasty, which revealed evidence of a disruption of the vestibular labyrinth and a wide dehiscence of the vestibule, which was immediately resurfaced. At the 2-month follow-up, the patient's pressure- and sound-related vestibular symptoms had disappeared. Pure-tone audiometry showed a reduction in the air-bone gap with a slight deterioration of bone conduction and an improvement in the air-conduction threshold. Fistulization of the otic capsule produces a "third window," which can lead to a dehiscence syndrome. One possible cause is a cholesteatoma of the middle ear or petrous bone. When the vestibule is invaded by a cholesteatoma, hearing is almost invariably lost, either pre- or postoperatively. However, in our case, wide opening of the vestibule resulted in hearing preservation.
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Colesteatoma/congénito , Fístula/complicaciones , Enfermedades del Laberinto/complicaciones , Equilibrio Postural , Trastornos de la Sensación/etiología , Adulto , Colesteatoma/complicaciones , Pérdida Auditiva Conductiva/etiología , Humanos , Masculino , Náusea/etiología , Síndrome , Vértigo/etiología , Enfermedades Vestibulares/etiologíaRESUMEN
OBJECTIVES/HYPOTHESIS: To assess the utility of imaging in planning intratympanic (IT) gentamicin (Gent) treatment in Ménière's disease (MD), we compared the dosage and outcomes of ITGent with the severity and extent of endolymphatic hydrops (EH), as evaluated by three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) sequence in a 3-T magnetic resonance imaging (MRI) unit, after IT gadolinium administration. STUDY DESIGN: Retrospective review. METHODS: A total of 18 patients (10 males and 8 females; age, 28-78 years; median age, 53.2 years) with definite MD participated in the investigation. The duration of the disease ranged from 8 months to 9 years (median, 2 years), with a prevalence of vertigo spells ranging from 0.8 to 8 per month (median, 2.2), as calculated in the last 6 months. A 3D-FLAIR MRI was performed 24 hours after IT injection of diluted gadobutrol. ITGent injection was performed within a variable period of time, from 1 week to 3 weeks after 3D-FLAIR MRI. The degree and extension of EH as evaluated by 3D-FLAIR MRI were compared with the number of injections necessary to cure vertigo attacks. Vertigo results, functional level scale modifications, variations in caloric excitability, and pure-tone average modifications. RESULTS: No statistically significant correlation was observed between severity of EH and outcomes of ITGent administration. CONCLUSIONS: The hypothesis of a reduced effect of Gent administered intratympanically in the presence of severe EH, owing to obstacled diffusion along the perilymphatic compartments, has not been confirmed in the present investigation.
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Endolinfa/metabolismo , Gadolinio DTPA , Gentamicinas/administración & dosificación , Imagen por Resonancia Magnética/métodos , Enfermedad de Meniere/diagnóstico , Adulto , Anciano , Antibacterianos/administración & dosificación , Medios de Contraste/farmacocinética , Femenino , Estudios de Seguimiento , Gadolinio DTPA/farmacocinética , Gentamicinas/uso terapéutico , Humanos , Imagenología Tridimensional , Inyecciones , Masculino , Enfermedad de Meniere/tratamiento farmacológico , Enfermedad de Meniere/metabolismo , Persona de Mediana Edad , Pronóstico , Estudios Retrospectivos , Membrana TimpánicaRESUMEN
OBJECTIVE: To verify the hypothesis that intratympanic (IT) gentamicin (Gent) treatment in Ménière's disease (MD) is capable of reducing endolymphatic hydrops (EH), as evaluated by 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) sequence in a 3-Tesla magnetic resonance imaging (MRI) unit, after IT gadolinium administration. PATIENTS: A total of 8 patients (5 men and 3 women; aged 40-78 yr; median, 60 yr) with definite MD participated in the investigation. The duration of the disease ranged from 1 to 10 years (median, 4 yr), with a prevalence of vertigo spells of 1 to 6 per month (median, 3.1), as calculated in the last 6 months. INTERVENTION: A 3D-FLAIR MRI was performed 24 hours after IT injection of diluted gadobutrol. Intratympanic Gent injection was performed in a period variable from 1 to 3 weeks after 3D-FLAIR MRI. A single-shot administration protocol was attempted with additional injections administered on demand in the case of relapsing vertigo spells. MRI was repeated after 3 to 12 months (median, 8 mo) after treatment. MAIN OUTCOME MEASURE: The degree and extension of EH as evaluated by 3D-FLAIR MRI was compared from images obtained pre- and post-ITGent administration. RESULTS: After ITGent administration, 4 patients did not show any MRI modification, 3 patients showed a worsening of EH in one site, and 1 patient showed a worsening in two sites. No subjects presented reduction of EH. CONCLUSION: No evidence of reduced EH following ITGent treatment has been shown in the present imaging investigation.
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Hidropesía Endolinfática/patología , Gentamicinas/uso terapéutico , Imagen por Resonancia Magnética , Enfermedad de Meniere/tratamiento farmacológico , Adulto , Anciano , Oído Interno/patología , Hidropesía Endolinfática/etiología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Masculino , Enfermedad de Meniere/complicaciones , Persona de Mediana EdadRESUMEN
OBJECTIVE: To evaluate the presence and the degree of endolymphatic hydrops (EHs) in patients with unilateral Ménière's disease (MD), as a function of duration of the disease, estimated using a 3-dimensional fluid-attenuated inversion recovery sequence in a 3-Tesla magnetic resonance imaging unit, after intratympanic gadolinium administration. PATIENTS: A total of 32 patients (21 male and 11 female subjects, aged 25-78 yr; median, 56 yr) participated in the investigation. The duration of the disease ranged from 2 months to 10 years (median, 3 yr), with a prevalence of vertigo spells in the last 6 months ranging from 0.5 to 8 per month (median, 2.5). INTERVENTION: A 0.6-ml solution of gadobutrol (1 mmol/ml) diluted 1:7 in saline was injected in the affected ear through the inferior-posterior quadrant of the tympanic membrane, using a 22-gauge spinal needle. The patient was kept with the head rotated 45 degrees contralaterally for 30 minutes after each injection. Twenty-four hours later, a 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging was performed. MAIN OUTCOME MEASURE: Perilymphatic enhancement was evaluated in different portions of the labyrinth as a function of MD duration. RESULTS: Reduced or absence of enhancement of the vestibule occurred precociously and occurred in all subjects at long term. The prevalence of enhancement abnormalities in the cochlea and the semicircular canals was directly proportional to MD duration. At long term, the vestibule and the cochlea showed a more severe hydropic involvement compared with semicircular canals. A statistical significant correlation between enhancement abnormalities and MD duration was observed for most inner ear sites. CONCLUSION: The increased prevalence and severity of EH with the duration of MD indicates that hydrops is a progressive degenerative phenomenon. The frequent abnormality in the vestibule and, secondarily, in the cochlea is in line with some histopathologic investigations. It remains to be clarified whether hydropic changes are related to specific signs and symptoms of MD.
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Progresión de la Enfermedad , Enfermedad de Meniere/patología , Membrana Timpánica/patología , Adulto , Femenino , Gadolinio DTPA/administración & dosificación , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVE: To evaluate the reliability of magnetic resonance imaging performed after intratympanic gadolinium administration in evidencing endolymphatic hydrops in patients with Ménière's disease (MD). PATIENTS: A total of 26 patients (18 male and 8 female subjects, aged 25-78 yr; median age, 56 yr) with definite MD and 12 subjects (8 male and 4 female subjects, aged 31-75 yr; median age, 51 yr) with various unilateral non-MD disorders of the inner ear were examined. INTERVENTION: A 0.6-ml solution of gadobutrol (1 mmol/ml), diluted 1:7 in saline, was injected in the affected ear through the inferior-posterior quadrant of the tympanic membrane, using a 22-gauge spinal needle. In 9 MD patients, the contralateral ear also was injected. The patient was kept with the head rotated 45 degrees contralaterally for 30 minutes after each injection. Twenty-four hours later, a 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging using a 3 Tesla unit was performed. MAIN OUTCOME MEASURE: Perilymphatic enhancement was evaluated in different portions of the labyrinth in MD ears and compared with the outcomes obtained in the non-MD ears. RESULTS: All MD ears showed impaired perilymphatic enhancement of variable degrees. No enhancement defects could be observed in all examined contralateral unaffected ear of the patients with MD, as well as in 11 of the 12 ears of the subjects with various unilateral non-MD disorders. CONCLUSION: Perilymphatic enhancement defect of variable degrees is observed in the pathologic ear of every patient with MD. The consistency of this phenomenon in MD ears and the complete enhancement in most of the ears without MD safely enable to attribute these findings to endolymphatic hydrops. It is likely in the near future that imaging may be used to achieve a certain diagnosis of MD in life.
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Hidropesía Endolinfática/diagnóstico , Gadolinio/administración & dosificación , Imagen por Resonancia Magnética , Enfermedad de Meniere/complicaciones , Membrana Timpánica , Adulto , Anciano , Medios de Contraste/administración & dosificación , Hidropesía Endolinfática/complicaciones , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Persona de Mediana EdadRESUMEN
The objective of the study was to compare the outcomes of a series of diagnostic parameters in Ménière's disease (MD) patients with the extent of endolymphatic hydrops (EH) as shown by magnetic resonance imaging (MRI) performed after intra-tympanic gadolinium administration using 18 patients (13 males and 5 females, age 25-78 years, median age 54.3 years) with definite MD. A 0.6-ml solution of Gadobutrol (1 mmol/ml) diluted 1:7 in saline was injected through the inferior-posterior quadrant of the tympanic membrane, using a 22-gauge spinal needle. The patient was kept with the head rotated 45° contralaterally for 30 min after the injection. Twenty-four hours later, three-dimensional fluid-attenuated inversion recovery MRI, using a 3-Tesla unit, was performed. Prevalence and extension of EH in MD patients was evaluated and correlated with age, duration and stage of the disease, frequency of attacks, time interval from the last attack, functional level scale, tinnitus, aural fullness, caloric stimulation, electrocochleography, and vestibular evoked myogenic potentials. All patients showed impaired enhancement of the inner ear of variable degree with the vestibular portion of the labyrinth more frequently involved than the cochlea. Abnormal vestibular evoked myogenic potentials, duration, and stage of the disease were significantly correlated to the number of inner ear sites involved. Modern imaging makes possible the identification of the endolymphatic hydrops in MD patients, improving diagnostic accuracy. The role of hydrops in the clinical manifestations and its correlation with most of the diagnostic parameters remain, however, not completely clear.
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Medios de Contraste/administración & dosificación , Imagen por Resonancia Magnética , Enfermedad de Meniere/diagnóstico , Compuestos Organometálicos , Adulto , Anciano , Audiometría de Respuesta Evocada , Pruebas Calóricas , Oído Interno/patología , Hidropesía Endolinfática/diagnóstico , Femenino , Gadolinio , Humanos , Inyecciones , Masculino , Persona de Mediana Edad , Membrana Timpánica , Potenciales Vestibulares Miogénicos EvocadosRESUMEN
OBJECTIVE: To evaluate the value of half-Fourier acquisition single-shot turbo-spin-echo diffusion-weighted magnetic resonance imaging (HASTE DW MRI) using a 3-Tesla (3T) unit in the diagnosis of primary and relapsing cholesteatoma. STUDY DESIGN: Retrospective observational investigation. SETTING: Tertiary referral center. PATIENTS: Seventeen patients suspected of having a primary cholesteatoma without clear clinical evidence of the lesion, and 13 patients who were candidates to a second-stage tympanoplasty to rule out a relapsing cholesteatoma or reconstruct the ossicular chain were investigated. INTERVENTION: All patients were scanned in a 3T scanner with a 4-channel head coil using T2 HASTE DW MRI technique sequences in axial and coronal planes covering the middle ear and mastoid regions. MAIN OUTCOME MEASURE: Images were considered positive for cholesteatoma in the presence of a hyperintense, patchy-like lesion in the petrous bone. RESULTS: Images showed a high signal intensity suggestive of primary cholesteatoma in 10 of 17 patients and of relapsing cholesteatoma in 7 of 13 patients. Of the 17 subjects, 15 with positive MRI findings were operated on, and the presence of cholesteatoma (ranging from 2 to 20 mm in size) was confirmed at surgery. Of the 13 subjects shown to be negative on HASTE DW MRI for cholesteatoma, 11 were operated on and were all confirmed to be cholesteatoma-free. CONCLUSION: Half-Fourier acquisition single-shot turbo-spin-echo diffusion-weighted magnetic resonance imaging technique, using a 3T unit, may be a diagnostic tool for a rapid and highly reliable discrimination between cholesteatomatous and noncholesteatomatous tissue in the middle ear, with 100% of positive and negative predictive values.
Asunto(s)
Colesteatoma del Oído Medio/diagnóstico , Imagen de Difusión por Resonancia Magnética/métodos , Adulto , Anciano , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Recurrencia , Estudios Retrospectivos , Sensibilidad y EspecificidadRESUMEN
OBJECTIVE: To evaluate the results obtained in treating superior semicircular canal dehiscence by plugging and resurfacing the defect via the transmastoid approach. PATIENTS: Six patients (30-70 yr old) who had disabling semicircular canal dehiscence syndrome underwent surgery. INTERVENTION: After a wide mastoidectomy and skeletonization of the semicircular canals, a shell of bone covering the middle fossa lateral to the superior semicircular canal was removed. The exposed dura was gently retracted and the canal skeletonized. Bone dust mixed with fibrine glue and bone wax were pressed to plug the dehiscent portion of the canal, and a slice of cortical bone was inserted to resurface it. MAIN OUTCOME MEASURE: Recovery from vestibular and auditory symptoms was evaluated. RESULTS: No intraoperative or postoperative complications occurred. Patients experienced an immediate relief of symptoms attributable to the dehiscence. CONCLUSION: A superior semicircular canal dehiscence may be plugged and resurfaced via the transmastoid approach, thus avoiding the more invasive middle fossa craniotomy.
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Apófisis Mastoides/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos Quirúrgicos Otológicos/métodos , Canales Semicirculares/anomalías , Canales Semicirculares/cirugía , Enfermedades Vestibulares/cirugía , Adulto , Anciano , Umbral Auditivo , Potenciales Evocados Auditivos , Femenino , Humanos , Masculino , Apófisis Mastoides/diagnóstico por imagen , Persona de Mediana Edad , Radiografía , Canales Semicirculares/diagnóstico por imagen , Síndrome , Resultado del Tratamiento , Enfermedades Vestibulares/diagnóstico por imagen , Pruebas de Función VestibularRESUMEN
OBJECTIVES/HYPOTHESIS: The use of a rigid esophagoscope during tracheoesophageal puncture for speaking valve insertion in laryngectomized patients may be hindered by stenosis of the esophagus, or arthritic deformation of the spine, limiting extension of the neck. To prevent complications we currently perform a blind technique in these patients with the use of a rigid hysterometer instead of the esophagoscope. METHODS: Ten patients underwent secondary tracheoesophageal puncture using a rigid hysterometer. This was inserted through the mouth and gently advanced along the cervical esophagus to the level of the tracheostomy. A transverse incision was made on the posterior membranaceous wall of the trachea to enable the hysterometer to enter the tracheal lumen. The curved cannula of a Provox trocar was retrogradely inserted into the fistula following the hysterometer as a guide. After withdrawing the hysterometer, a Provox flexible guidewire was introduced into the cannula and advanced up to the oral cavity to anchor a Blom-Singer prosthesis. Withdrawal of the guidewire enabled the prosthesis to be housed in the fistula. RESULTS: All patients had a successful surgical outcome without any intra- or postoperative complications. The resulting fistula was adequate and enabled patients to wear their prostheses without trouble and to quickly acquire an intelligible voice. CONCLUSIONS: The limited thickness allows easy advance of the hysterometer beyond esophageal stenotic tracts, and its particular curved conformation permits progression toward the level of the tracheostomy in patients who cannot assume a relaxed, extended supine position on the operating table.
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Esofagoscopía , Esófago/cirugía , Laringe Artificial , Implantación de Prótesis/métodos , Tráquea/cirugía , Anciano , Femenino , Humanos , Laringoscopía , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/prevención & control , Implantación de Prótesis/instrumentación , Punciones , Resultado del TratamientoRESUMEN
The objective of the present study was to evaluate the efficacy of fat graft myringoplasty in repairing residual or recurrent tympanic membrane perforation. A retrospective analysis was performed on 31 patients, aged 25-57 years (mean 43.3), submitted to myringoplasty revision using fat graft. Fourteen were males and 17 females. Perforation size ranged from 1 to 5 mm. Follow-up time ranged from 4 to 62 months (mean 26 months). Fat graft myringoplasty was performed under local anesthesia, using ear lobe fat in 26 patients and abdominal fat in five patients closure of tympanic membrane perforation was achieved in 87.1% of ears. No modification of the hearing level was evidenced at the statistical analysis. Fat graft myringoplasty is a safe, effective and minimally invasive procedure, suitable to repair small residual/recurrent perforations of the tympanic membrane. The angiogenic properties of the fat are ideal to overcome the poor vascular supply in the vicinity of the tympanic membrane perforation.
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Tejido Adiposo/trasplante , Miringoplastia/métodos , Complicaciones Posoperatorias/cirugía , Perforación de la Membrana Timpánica/cirugía , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Otorrinolaringológicos , Reoperación , Insuficiencia del TratamientoRESUMEN
UNLABELLED: Previous studies have considered only patients with neurofibromatosis type 2 (NF2) older than 12 years as candidates for an auditory brainstem implant (ABI). Our study expands the potential criteria to include both children and adult subjects with other cochlear or cochlear nerve malfunctions who either would not benefit at all from a cochlear implant (eg, cochlear nerve aplasia or avulsion) or whose benefit was or would be severely compromised (eg, cochlear ossification, cochlear fracture). STUDY DESIGN: In our department, over the period from April 1997 to September 2002, 29 patients, 20 adults and 9 children, were fitted with ABIs. Their ages ranged from 14 months to 70 years. Thirteen subjects had tumors, 10 NF2 and 3 solitary vestibular schwannoma, and 16 patients had a variety of nontumor (NT) cochlear or cochlear nerve diseases. A retrosigmoid-transmeatal approach was used in T and a retrosigmoid approach in NT patients. The electrode array was inserted into the lateral recess of the fourth ventricle and correct electrode positioning was monitored with the aid of electrically evoked auditory brainstem responses (EABRs). RESULTS: Correct implantation was achieved in all patients. No complications were observed due to implantation surgery or related to ABI activation or long-term use. Auditory sensations were induced in all patients with various numbers of electrodes (from 5 to 15). Different pitch sensations were identifiable with different electrode stimulation. Closed-set word recognition, open-set sentence recognition, and speech tracking scores achieved by the patients are reported in detail. The auditory performance of the patients showed significantly better outcomes than controls (Multicentric European clinical investigations on ABI with NF2). CONCLUSION: We have shown that the indications for the ABI can be extended to include NT patients with severe cochlear and/or cochlear nerve abnormalities. The degree of auditory benefit varies as a function of the underlying pathological conditions, with NT subjects exhibiting significantly better outcomes than the T patients.
Asunto(s)
Implantación Auditiva en el Tronco Encefálico/métodos , Traumatismos Craneocerebrales/cirugía , Pérdida Auditiva Sensorineural/cirugía , Adolescente , Adulto , Anciano , Implantación Auditiva en el Tronco Encefálico/tendencias , Implantes Auditivos de Tronco Encefálico , Niño , Preescolar , Enfermedades Cocleares/complicaciones , Enfermedades Cocleares/cirugía , Traumatismos Craneocerebrales/complicaciones , Potenciales Evocados Auditivos del Tronco Encefálico/fisiología , Femenino , Pérdida Auditiva Sensorineural/diagnóstico , Pérdida Auditiva Sensorineural/etiología , Pérdida Auditiva Sensorineural/fisiopatología , Pruebas Auditivas , Humanos , Lactante , Masculino , Persona de Mediana Edad , Neuroma Acústico/complicaciones , Neuroma Acústico/cirugía , Estudios Retrospectivos , Resultado del Tratamiento , Enfermedades del Nervio Vestibulococlear/complicaciones , Enfermedades del Nervio Vestibulococlear/cirugíaRESUMEN
OBJECTIVES: To compare the 2 surgical techniques most commonly used during vestibular schwannoma (VS) surgery, i.e., the middle fossa (MF) and the retrosigmoid-transmeatal (RS-TM) routes, when hearing preservation is attempted. STUDY DESIGN: A longitudinal study of a series of consecutive patients operated on with the 2 techniques by the same surgeon was conducted. Selection criteria included tumor confined to the internal auditory canal (IAC) with a length ranging from 4 to 12 mm and hearing class A or B. Patients were alternately assigned to 1 of the 2 groups regardless of auditory class and distance of the tumor from the IAC fundus. Thirty-five subjects were operated on with the RS-TM technique and 35 via the MF route. RESULTS: No significant differences in auditory and facial nerve function results between the 2 techniques were observed. The RS-TM approach, however, showed better facial nerve results at discharge. VS size, IAC enlargement, and, particularly, the distance from the IAC fundus were found to influence the postoperative results more than the type of approach itself. CONCLUSIONS: The MF approach has been described as being the better technique for VS surgery in terms of auditory results. However, this claim lacks statistical substantiation because no prospective studies are to be found in the literature. The present longitudinal investigation shows that the MF approach does not afford any particular advantages over the RS-TM route in terms of auditory results in intracanalicular VS, with the exception of tumors reaching the IAC fundus.
Asunto(s)
Neuroma Acústico/cirugía , Adulto , Anciano , Fosa Craneal Media , Humanos , Persona de Mediana Edad , Procedimientos Quirúrgicos Otológicos/métodos , Estudios ProspectivosRESUMEN
OBJECTIVES: There is growing evidence that early application of a cochlear implant in children affected by profound congenital hearing loss is of paramount importance for the development of an adequate auditory performance and language skills. For these reasons and as a result of advances in audiologic diagnosis and an enhanced awareness of the safety of cochlear implants, the age of implantation has substantially decreased over recent years. Children aged as little as 12 months are now being implanted in some centers. On the basis of our experience with very young children, we believe that the date of implantation may be further reduced to only 4 to 6 months of age. STUDY DESIGN: Over the period from November 1998 to April 2004, 103 children have been fitted with cochlear implants and 11 with auditory brainstem implants in our department, including 65 children aged below 3 years. The present study focuses on 10 children aged less than 12 months fitted with cochlear implants from November 1998 to December 2003. METHODS: The children's ages ranged from 4 to 11 (mean 9.5) months. Five were males and five females. All received a Nucleus CI 24 M. Postoperative auditory performance, as evaluated at the latest follow-up, was based on the category of auditory performance (CAP). The results obtained in these 10 children were compared with those obtained with cochlear implants in children belonging to older age brackets. The criteria used to assess speech performance were onset of babbling onset and babbling spurt, and the results observed were compared with those of a control group of 10 normally hearing children. RESULTS: Surgery was uneventful, and no immediate or delayed complications were encountered. Auditory performance was seen to increase as function of early age of implantation and length of implant use. All 10 children had a CAP score of 3 within 6 months of cochlear implant activation. The onset of babbling occurred very early (i.e., within 1 to 3 months of activation of the implant in all 10 patients), regardless of age at implantation, whereas the babbling spurt was recorded at times ranging from 3 to 5 months after implant activation. The positive impact of early implantation on babbling was clearly shown by the fact that the earlier the activation of the cochlear implant, the closer the results were to the outcomes of normally hearing children. CONCLUSIONS: We encourage very early implantation to facilitate a series of developmental processes occurring in the critical period of initial language acquisition. The indices we used in the present study (i.e., CAP and babbling) suggest that early cochlear implantation tends to yield normalization of audio-phonologic parameters, which enables us to consider the performance of children implanted very early as being similar to that of their normally hearing peers.
Asunto(s)
Implantación Coclear , Factores de Edad , Implantación Auditiva en el Tronco Encefálico , Implantes Auditivos de Tronco Encefálico , Estudios de Casos y Controles , Implantes Cocleares , Sordera/rehabilitación , Femenino , Humanos , Lactante , Desarrollo del Lenguaje , Masculino , Habla , Factores de TiempoRESUMEN
OBJECTIVE: To investigate the auditory rehabilitative results achieved in five patients with cochlear implants (CIs) who subsequently received, due to poor results, auditory brainstem implants (ABIs). MATERIAL AND METHODS: Between April 1997 and March 2003, 37 patients (age range 14 months to 70 years) were fitted with ABIs in our ENT Department. Fourteen subjects had neurofibromatosis type 2 and 23 were non-tumor patients who had cochlea or cochlear nerve disease. Five subjects had previously been treated with a CI and received an ABI owing to the poor results achieved. One child had bilateral undiagnosed cochlear nerve aplasia and one was suffering from auditory neuropathy; three adults had total cochlear ossification. RESULTS: The open-set sentence recognition score (auditory-only mode) 6-8 months after ABI activation ranged from 0% to 100% in adults. In 1 subject the speech-tracking score was 56 words/min with the ABI. The two children who had achieved no hearing ability with their CI were able to detect sounds and words as early as 3 months after activation of the ABI. CONCLUSION: CI failure as a result of anatomical abnormalities can be remedied by an ABI.
Asunto(s)
Implantación Auditiva en el Tronco Encefálico , Implantación Coclear , Pérdida Auditiva/cirugía , Adolescente , Adulto , Anciano , Implantes Auditivos de Tronco Encefálico , Niño , Preescolar , Enfermedades Cocleares/complicaciones , Implantes Cocleares , Potenciales Evocados Auditivos , Potenciales Evocados Auditivos del Tronco Encefálico , Pérdida Auditiva/etiología , Pérdida Auditiva/fisiopatología , Humanos , Lactante , Persona de Mediana Edad , Neuroma Acústico/complicaciones , Percepción del Habla , Insuficiencia del TratamientoRESUMEN
OBJECTIVE: The present article investigates on an individual basis the performance achieved with the auditory brainstem implant in patients who had been treated unsuccessfully with a cochlear implant. STUDY DESIGN: An intrasubject comparison between results achieved with the cochlear implant and the auditory brainstem implant is reported. SETTING: Tertiary referral care. PATIENTS: Five subjects were fitted with an auditory brainstem implant in our department because of the poor results achieved with cochlear implants. Two were children, one with bilateral cochlear nerve aplasia and one suffering from auditory neuropathy. Three were adults with complete cochlear ossification. INTERVENTION: A retrosigmoid approach was used in all subjects. Electrically evoked auditory brainstem responses and neural response telemetry were used to monitor electrode positioning. RESULTS: No complications were observed due to implantation surgery or related to activation or long-term use of the auditory brainstem implant. Auditory sensations were induced in all patients with varying numbers of electrodes (from 9-16). In all three adults, the cochlear implant did not allow either word/sentence discrimination or speech tracking, whereas the auditory brainstem implant permitted discrimination of two- or three-syllable words with scores from 85 to 100%. In the two adults with a follow-up of 5 and 6 months after auditory brainstem implant activation, the open-set sentence recognition scores (auditory-only mode) were 70% and 100%, respectively, and the speech-tracking scores were 27 and 40 words/min, respectively. One patient with a follow-up of only 3 months scored 0% in both sentence recognition and speech tracking. The two children who had achieved no hearing ability with the cochlear implant were already able to detect sounds and words as early as 2 months after activation of the auditory brainstem implant and are showing progressive improvement in their performance. CONCLUSION: Auditory brainstem implantation may be a very powerful rehabilitative treatment after cochlear implant failure. The possibility of using the auditory brainstem implant as first-choice therapy in some categories of deaf patients (e.g., subjects with auditory neuropathy or cochlear ossification) who are currently treated with cochlear implantation is discussed.
Asunto(s)
Implantes Auditivos de Tronco Encefálico , Implantación Coclear , Pérdida Auditiva Sensorineural/terapia , Terapia Recuperativa , Adulto , Niño , Preescolar , Potenciales Evocados Auditivos , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Atención Perioperativa , Insuficiencia del TratamientoRESUMEN
OBJECTIVE: To compare the advantages, disadvantages, and results obtained with the middle fossa and retrosigmoid-transmeatal approaches during pure intracanalar vestibular schwannoma surgery in an attempt to preserve hearing. STUDY DESIGN: Prospective study of patients treated from 1998 to 2001. SETTING: Tertiary care referral center. PATIENTS: Patients with intracanalar vestibular schwannoma (size ranging from 4 to 12 mm), 25 operated on with the retrosigmoid-transmeatal technique and 25 via the middle fossa route. MAIN OUTCOME MEASURES: Facial nerve and auditory function were examined at 1 year with both techniques. Auditory results were also evaluated as a function of tumor size, distance from the internal auditory canal fundus, and internal auditory canal enlargement. RESULTS: The results indicated no significant difference in facial nerve and auditory function results between the two techniques. The retrosigmoid-transmeatal approach, however, yielded better facial nerve function results at discharge. Postoperative hearing was better when the distance from the fundus was greater than 3 mm, when the size of the vestibular schwannoma was equal to or less than 7 mm, and when the internal auditory canal enlargement was less than 3 mm. CONCLUSIONS: The middle fossa approach does not afford any particular advantages over the retrosigmoid-transmeatal approach in terms of auditory results. Facial nerve function is less satisfactory in the short term, when the middle fossa route is used, but can be improved by decompression and gentle displacement of the facial nerve in its labyrinthine portion.
Asunto(s)
Percepción Auditiva , Neuroma Acústico/complicaciones , Neuroma Acústico/cirugía , Procedimientos Quirúrgicos Otológicos/métodos , Hueso Temporal/cirugía , Umbral Auditivo , Potenciales Evocados Auditivos del Tronco Encefálico , Nervio Facial/fisiopatología , Femenino , Audición , Humanos , Masculino , Monitoreo Intraoperatorio , Neuroma Acústico/fisiopatología , Procedimientos Quirúrgicos Otológicos/efectos adversos , Estudios ProspectivosRESUMEN
OBJECTIVE: To verify the possibility of auditory habilitation in children with aplasia and hypoplasia of the cochlear nerve by direct electrical stimulation of the cochlear nuclei with an auditory brainstem implant. STUDY DESIGN: Retrospective case review. SETTING: Study conducted at the Ear, Nose, and Throat Department of the University of Verona, Italy. PATIENTS: Three children, aged 4, 3, and 2 years, respectively, with severe bilateral cochlear malformations and cochlear nerve aplasia have received an auditory brainstem implant at this institution in the past 2 years. INTERVENTION: The classic retrosigmoid approach was used. Correct positioning of the electrodes was evaluated using electric auditory brainstem responses and neural response telemetry. Before the patients were discharged, high-resolution computed tomography with a bone algorithm reconstruction technique was performed to evaluate electrode placement. The auditory brainstem implant was activated 30 to 60 days after implantation. RESULTS: No postoperative complications were observed. To date, 21, 18, and 8 electrodes, respectively, have been activated in the three children. The first patient, 12 months after activation, had achieved good environmental sound awareness, good speech detection, and some speech recognition. The second child, 8 months after activation, had achieved good environmental sound awareness and moderate speech detection. The third patient, 1 month after activation, had obtained good environmental sound awareness. CONCLUSION: This study indicates that auditory brainstem implantation is technically feasible in children with cochlear nerve aplasia. The early results suggest the possibility of achieving auditory habilitation with auditory brainstem implantation in this population.