Pemphigus/epidemiology , Adolescent , Adult , Age Distribution , Age Factors , Aged , Aged, 80 and over , Child , Child, Preschool , Female , France/epidemiology , Humans , Incidence , Infant , Infant, Newborn , Male , Middle Aged , Mortality/trends , Prognosis , Sex Factors , Young Adult
BACKGROUND: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Mitotane (Lysodren) is used for treating adrenocortical carcinoma. Currently, no side effects concerning oral and genital mucosa have been reported. CASE SUMMARY: This case report is about a 50 years old woman. Six months after the initiation on mitotane treatment, she developed erosive lesions located on the oral and vaginal mucosa. These drug reactions were diagnosed as erosive lichen planus by the biopsy. This lichenoid lesions were resistant to the usual treatments, mitotane being at the time not replaceable. CONCLUSION: This case describes an unreported adverse effect of mitotane, it is - to our knowledge - the 1st description of erosive lichenoid drug reaction due to Mitotane.
Antineoplastic Agents, Hormonal/adverse effects , Lichenoid Eruptions/chemically induced , Mitotane/adverse effects , Mouth Diseases/chemically induced , Vulvar Diseases/chemically induced , Adrenal Cortex Neoplasms/drug therapy , Carcinoma/drug therapy , Female , Humans , Middle Aged
BACKGROUND: Patients with burning mouth syndrome (BMS) are frequently treated with antidepressants. Selective serotonin reuptake inhibitors (SSRIs) are increasingly used. Nonetheless, few studies have examined the effects of SSRIs in BMS. OBJECTIVE: We performed a retrospective study to confirm the need for a prospective study on this topic in the future. PATIENTS AND METHODS: 51 patients suffering from primary BMS were included in this study. RESULTS: The frequency of side effects due to SSRIs was low, with mainly digestive side effects. Treatment with SSRIs was more efficient in patients reporting a psychogenic origin for their symptoms. Antidepressants were more frequently stopped when patients did not declare such an origin. CONCLUSIONS: SSRIs appear to be effective and well tolerated. Declaring a psychogenic component may be considered as a potentiating or predictive factor for the efficacy of treatment with SSRIs. These results should be confirmed by a prospective randomised study.
Antidepressive Agents, Tricyclic/therapeutic use , Burning Mouth Syndrome/drug therapy , Selective Serotonin Reuptake Inhibitors/therapeutic use , Aged , Burning Mouth Syndrome/diagnosis , Female , Humans , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Treatment Outcome
