Client Perspectives on the Development of a Rapid PrEP Initiative at a Sexual Health Center in New Orleans, Louisiana.

Uptake of PrEP remains suboptimal, especially in the Southern United States. Same-day or "Rapid PrEP Initiatives" (RPIs) in sexual health centers (SHCs) could facilitate access and overcome barriers to PrEP. We studied the adaptation of an RPI from Denver, Colorado to an SHC in New Orleans, Louisiana. Through focus group discussions (FGDs) with local SHC staff and PrEP providers, we developed a preliminary RPI model. In 5 FGDs with SHC clients referred for or taking PrEP, we gathered adaptation recommendations and feedback on model acceptability, feasibility, and utility. Providers and clients voiced unanimous support for the RPI. Clients favored the ease of same-day PrEP initiation and emphasized a desire for navigational support, financial counseling, and integration of PrEP care with their other clinical needs. Clients recommended that SHC providers discuss PrEP and HIV with all patients, regardless of providers' perception of risk. Next steps include small-scale implementation and evaluation.

Client Perspectives on the Development of a Same-Day PrEP Initiation Protocol at a Sexual Health Center in New Orleans, LouisianaUptake of PrEP remains low, especially in the Southern United States. Same-day or "Rapid PrEP Initiatives" (RPIs) in sexual health centers (SHCs) could facilitate access and overcome barriers to PrEP. RPIs provide eligible clients with an opportunity to start PrEP on the same day they receive screening for sexually transmitted infections. We studied the adaptation of an RPI from Denver, Colorado, to an SHC in New Orleans, Louisiana. Through focus group discussions (FGDs) with local SHC staff and PrEP providers, we developed a preliminary RPI model. In five FGDs with SHC clients referred for or taking PrEP, we gathered adaptation recommendations and feedback on RPI model acceptability, feasibility, and utility. Providers and clients voiced unanimous support for the RPI. Clients favored the ease of same-day PrEP initiation and emphasized a desire for navigational support, financial counseling, and integration of PrEP care with their other clinical needs. Clients recommended that SHC providers discuss PrEP and HIV with all patients, regardless of providers' perception of risk. Next steps include small-scale implementation and evaluation.

Diffusion, viscosity, and linear rheology of valence-limited disordered fluids.

We numerically investigate the dynamics and linear rheology of disordered systems made of patchy particles, focusing on the role of valence, temperature, and bonding mechanism. We demonstrate that the dynamics is enslaved to bonding, giving rise to an activated behavior at low temperatures. By independently computing the diffusion constant and the viscosity from the simulations, we also confirm the validity of the Stokes-Einstein relation in valence-limited systems, with two caveats: (i) the diffusion constant requires a finite-size correction, at least at the intermediate density we investigate, and (ii) there is the onset of a breakdown that appears at the lowest temperatures considered. Finally, our results show that the storage and loss moduli of mixtures of divalent and M-valent particles exhibit an apparent power-law dependence on frequency, hinting at the possibility of using the composition to finely tune the rheological response of these materials. Our results compare well with literature experimental data on valence-limited DNA nanostars. In addition, the wealth of data we present and analyze here will help develop and test theoretical frameworks aimed at describing the dynamics of flexible limited-valence particles that self-assemble into disordered networks.

Polyphasic Approach and Potential Cyanotoxin Production by Planktothrix from the Río Grande de Comitán and Montebello Lakes National Park, Southern Mexico.

The development of anthropic activities during recent years has led to an increase in nutrient fluxes in the Río Grande de Comitán and Montebello Lakes National Park, Mexico. In turn, this has modified the dynamics of the biotic community, specifically favoring the presence of cyanobacteria tolerant to contamination. The continual and massive presence of Planktothrix species (spp.) in the system suggests a potential detrimental impact for economic issues and human health. In this study, we identify the morphological and molecular characteristics of Planktothrix populations from seven tropical (1,380-1,740 masl, 23.0-25.5°C) and calcareous lakes and two ponds from a water treatment plant. We also assess the ecological drivers that could be related to the presence of cyanotoxins in the system. The ecological preferences, morphology, 16S rRNA structure, and 16S-23S rRNA internal transcribed spacer found evidence for three species: P. agardhii distributed in neutral to slightly basic water (pH = 7.7-8.7), and P. spiroides and Planktothrix sp. in alkaline waters (pH = 9.1). The presence of the mcyE gene and its validation by liquid chromatography confirmed the presence of two microcystin variants (MC-RR and MC-LR) in at least three populations of P. agardhii. These microcystins put the health of the ecosystem and its inhabitants at risk, a condition that should be addressed and resolved with a water management and detoxification strategy in the basin.

Lepeophtheirus mondacola sp. nov. (Copepoda; Caligidae) parasitic on the shortjaw leatherjacket Oligoplites refulgens (Teleostei; Carangidae) in the Gulf of California, Mexico.

A new species of parasitic copepod, Lepeophtheirus mondacola sp. nov. (Siphonostomatoida; Caligidae), is described based on female and male specimens obtained from the shortjaw leatherjacket Oligoplites refulgens (Actinopterygii; Perciformes; Carangidae), captured in the southeastern Gulf of California off northwestern Mexico. The new species can be separated from its congeners by a combination of characters that includes: adult female with a subquadrate genital complex bearing slightly protruded posterolateral corners, two indistinct somites on the abdomen which, when combined together, is about two times longer than wide, a caudal ramus that is twice as long as it is wide, a postantennal process comprising a stout base and short claw, a dentiform process of the maxillule with two unequal tines, a maxilliped with a stout protopod and subchela, a sternal furca with a pair of bifurcated tines, a leg 3 exopod composed of 2 segments, five setae on the distal endopodal segment of leg 3 and a leg 4 exopod composed of three segments and armed with one long and two short apical spines on the distal exopodal segment; adult male with a suborbicular genital complex, an abdomen composed of one short and one long, indistinctly separated somites, a caudal ramus that is twice as long as it is wide, a stout postantennal process, a small triangular process at the base of the inner tine of the maxillulary dentiform process and a 3-segmented exopod on leg 4. Lepeophtheirus mondacola sp. nov. represents the first record of a species of Lepeophtheirus from a member of Oligoplites and the second caligid species reported from O. refulgens.

The genus Cletocamptus (Harpacticoida, Canthocamptidae): a reappraisal, with proposal of a new subfamily, a new genus, and a new species.

A new species of Cletocamptus closely related to C.helobius was found in sediment samples taken from a polluted estuarine system in north-western Mexico. The genus Cletocamptus was relegated to species incertae sedis in 1986, and this finding prompted us to evaluate the current taxonomic position of the genus within the Canthocamptidae. The latter has been subdivided in several, seemingly unnatural subfamilies in the past to better understand the relationships between its constituent taxa. In this study we propose a new subfamily, the Cletocamptinaesubfam. nov. for Amphibiperita, Cletocamptus, and Cletocamptoides gen. nov., defined by the synapomorphic subdistal ventral spinules on the rostrum. The genus Cletocamptoides gen. nov. is proposed for C.helobius, C.merbokensis, and C.biushelo sp. nov., and is supported by the 'cletodid' shape of the body and the reduced one-segmented endopod of the fourth swimming leg. Cletocamptus includes all the other species with long slender spinules on the posterior margin of prosomites and with the sexually modified inner spine on the second endopodal segment of the second swimming leg in the males. Amphibiperita retained the primitive female fifth leg with exopod and baseoendopod separated, and the primitive prehensile endopod of the first leg, but is defined by the loss of the antennary exopod. Other (syn)apomorphies are given, and the evolution of the mandibular palp is briefly discussed. Additionally, a diagnosis for the new subfamily, Cletocamptinae subfam. nov., an amended narrower diagnosis for Cletocamptus, the diagnosis for Cletocamptoides gen. nov., and a phylogenetic analysis supporting the proposal of these new taxa, are given.

Phylogenetic relationships among species of Tigriopus (Multicrustacea: Copepoda: Harpacticoida) with comments on its biogeography.

Here we present some hypothetical phylogenetic relationships and the evolutionary history of the harpacticoid copepod genus Tigriopus Norman, 1869 using morphological data. Cladistic analyses were performed with 21 morphological characters, including 15 ingroup and eight outgroup species. Inferred topology from Bayesian inference supported the monophyletic status of the genus, and revealed two main evolutionary lineages. One of these lineages (the brachydactylus-iagi lineage) comprises species from the Indo-Pacific, the northern Pacific, the southern Pacific, and the southern Atlantic; it is supported by the tetrasetose female P5 endopod. The fulvus-angulatus lineage is composed of three clusters with species from the north Atlantic and the Mediterranean Sea (the fulvus-brevicornis clade), the northwestern Pacific and the Indo-Pacific (the japonicus-sirindhoranae clade), and from the southern Pacific, the Indian Ocean, and the Southern Ocean (the crozettensis-angulatus clade). The groundpattern of the mandibular basis of the fulvus-angulatus lineage seems to include a bisetose mandibular basis, and, the presence of three setae on this segment in the japonicus-sirindhoranae clade is interpreted here as a character reversal. Biogeographic analyses suggest that the tropical Indo-Pacific region is the most probable ancestral area of the genus that diversified through vicariance events.

Evaluation of an HIV Pre-Exposure Prophylaxis Referral System: From Sexual Health Center to Federally Qualified Health Center Pre-Exposure Prophylaxis Clinic.

Innovative delivery strategies are needed to facilitate access to HIV pre-exposure prophylaxis (PrEP). The objective of this study was to evaluate a navigator-facilitated PrEP referral process from a sexual health center (SHC) to a co-located PrEP clinic as an alternative delivery model. Electronic health record (EHR) data were used to calculate the number of clients seen at the SHC in 2019. Charts were manually reviewed to determine whether a PrEP clinic referral was made and document type of referral method: face-to-face appointment scheduling with the navigator (warm handoff), EHR messaging to navigator to schedule the appointment at a later time (EHR message), or provision of navigator's contact information to the client (card only). In 2019, 2481 unique potentially PrEP-eligible clients were seen at the SHC; 220 (9%) received a PrEP referral. Of referred clients, median age was 30 years (interquartile range, 24-34), 182 (83%) were male, 89 (40%) were non-Hispanic Black, and 24 (11%) were Latinx. In total, 94/220 (43%) referred clients attended an initial PrEP visit with a provider, and the proportion attending by referral method was 81%, 36%, and 27% for warm handoff, EHR message, and card only, respectively (p < 0.0001). Despite co-location of these two clinics, there were significant drop-offs along the PrEP care continuum for this referral system. Warm handoff was the most effective referral method, but further efforts are needed to understand barriers to referral. Implementation of same-day PrEP services at SHCs is one potential solution to engaging additional clients.

Questionnaire to Assess Life Impact of Treatment by Intravitreal Injections (QUALITII): Development of a patient-reported measure to assess treatment burden of repeat intravitreal injections.

OBJECTIVE: To understand patient burden of treatment of repeated intravitreal injections (IVI) in the management of exudative retinal diseases. METHODS AND ANALYSIS: Participants were sampled from a large urban retina specialty practice in Houston, Texas, USA, based on history of ongoing receipt of IVI. The 50-item Questionnaire to Assess Life Impact of Treatment by Intravitreal Injections questionnaire was developed to evaluate the patient experience including discomfort, anxiety, inconvenience and satisfaction. Categorial principal components analysis (CATPCA) was performed to assess construct validity and internal consistency. A subset of these items was used to establish a measure of total treatment burden, referred to as the IVI Treatment Burden Score (TBS). RESULTS: 142 patients participated in this study. CATPCA analysis revealed five dimensions of patient burden: disruption of normal routine or capacity, anxiety, frequency of visits, chronicity of disease and perceived treatment value or satisfaction. Together, these dimensions accounted for 67% of variance explained. Cronbach's alpha was 0.97. The most frequently cited cause of discomfort was the feeling after anaesthetic wore off. The most common source of anxiety was fear of injection and associated discomfort or pain. Regarding inconvenience, patients reported temporary postinjection debilitation, requiring an average of 8 hours for recovery per treatment. The most frequently identified sources of satisfaction were confidence in the provider or treatment and interactions with staff. CONCLUSIONS: Understanding and quantifying the patient burden associated with repeated IVI for exudative retinal diseases can reveal opportunities to improve delivery methods. The TBS could serve to inform strategies to maximise treatment adherence and optimise patient experiences.

The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(ii) complex and toxicity of the ligand precursor for the marine benthic copepod Amphiascoides atopus.

The palladium-catalysed reaction of aryl halides and allylic alcohols is an attractive method for obtaining α,ß-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(ii) complex formed in situ has been found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcohols, with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(ii) complex for the harpacticoid copepod Amphiascoides atopus allowed us to contrast the efficiency of the catalytic system with the potential impact of the principal waste chemical in global aquatic ecosystems, which has not been previously addressed.

A new species of Robertgurneya Apostolov Marinov, 1988, with an illustrated record of R. rostrata (Gurney, 1927), an amended genus diagnosis and comments on R. soyeri (Apostolov, 1974) and R. spinulosa (Sars, 1911) (Harpacticoida: Miraciidae).

Quarterly sampling campaigns were carried out during year 2019 to study the effects of organic pollution on the diversity and abundance of meiofauna from a polluted coastal system in north-western Mexico. Amongst harpacticoids, the family Miraciidae Dana 1846 was by far the most abundant and diverse, and several new species and the proposal of some new genera of Stenheliinae Brady 1880 and Diosaccinae Sars 1906 will be published elsewhere. Amongst the Diosaccinae, the genus Robertgurneya Apostolov Marinov 1988 was one of the most abundant. This genus was proposed and diagnosed by Lang (1944, 1948) but after a complex taxonomical history, was made available by Apostolov Marinov (1988) who proposed an amended diagnosis and designated R. similis similis (Scott A. 1896) as the type species of the genus. Here I propose a new species, Robertgurneya mexicana sp. nov., and give a fully illustrated record of the widely distributed R. rostrata (Gurney 1927). The relationships amongst the species of Robertgurneya are not clear, but the new Mexican species shares with R. falklandiensis (Lang 1936) the elongated inner dimorphic spine on the basis of the male P1. Additionally, a new amended diagnosis for the genus Robertgurneya, as well as the reallocation of R. soyeri (Apostolov 1974) into Typhlamphiascus Lang 1944, and the creation of a new genus, Robertgurneyella gen. nov., for R. spinulosa (Sars 1911) are proposed.

On some new species of Stenheliinae Brady, 1880 (Copepoda, Harpacticoida, Miraciidae) from north-western Mexico, with the proposal of Lonchoeidestenhelia gen. nov.

Quarterly sampling campaigns during 2019 to study the diversity of meiofauna in a polluted estuary in northwestern Mexico revealed the subfamily Stenheliinae Brady, 1880 as one of the most important contributors to the diversity of benthic harpacticoids. Two new stenheliin species are described here. One of them was assigned to the, so far, monotypic genus Lonchoeidestenhelia gen. nov. defined by the autapomorphic modified proximal outer spinules on the sigmoid process of the male P2ENP2. The other species was assigned to Willenstenhelia Karanovic and Kim, 2014. Lonchoeidestenhelia gen. nov. shares the armature formula of the P1 EXP2 with Stenhelia, Anisostenhelia, and Beatricella, but seems to bear a sister-group relationship with the former two genera by the loss of one inner seta on the P2-P3 EXP3, the presence of two outer spine-like elements on the male P5EXP, and the displacement of the outer spine and medial and inner distal setae of P2ENP3, to an apical and subapical inner position, respectively, but is more closely related to Anisostenhelia by the overall shape of the male P2ENP2. Willenstenhelia reducta sp. nov. is attributed to a group of species composed of Wi. minuta, Wi. urania, and Wi. terpsichore characterized by the strongly reduced inner seta of the female P5 baseoendopod, but differs in the discrete female P5 baseoendopods and in the presence of one outer seta only on that segment. Willenstenhelia reducta sp. nov. is defined here by the autapomorphic loss of the outermost seta of the female P5 baseoendopod.

Non-classical 1p36 deletion in a patient with Duane retraction syndrome: case report and literature review.

BACKGROUND: Monosomy of 1p36 is considered the most common terminal microdeletion syndrome. It is characterized by intellectual disability, growth retardation, seizures, congenital anomalies, and distinctive facial features that are absent when the deletion is proximal, beyond the 1p36.32 region. In patients with proximal deletions, little is known about the associated phenotype, since only a few cases have been reported in the literature. Ocular manifestations in patients with classical 1p36 monosomy are frequent and include strabismus, myopia, hypermetropia, and nystagmus. However, as of today only one patient with 1p36 deletion and Duane retraction syndrome (DRS) has been reported. CASE PRESENTATION: We describe a patient with intellectual disability, facial dysmorphism, and bilateral Duane retraction syndrome (DRS) type 1. Array CGH showed a 7.2 Mb de novo deletion from 1p36.31 to 1p36.21. DISCUSSION: Our patient displayed DRS, which is not part of the classical phenotype and is not a common clinical feature in 1p36 deletion syndrome; we hypothesized that this could be associated with the overlapping deletion between the distal and proximal 1p36 regions. DRS is one of the Congenital Cranial Dysinnervation Disorders, and a genetic basis for the syndrome has been extensively reported. The HES3 gene is located at 1p36.31 and could be associated with oculomotor alterations, including DRS, since this gene is involved in the development of the 3rd cranial nerve and the 6th cranial nerve's nucleus. We propose that oculomotor anomalies, including DRS, could be related to proximal 1p36 deletion, warranting a detailed ophthalmologic evaluation of these patients.

Fully coupled fluid-electro-mechanical model of the human heart for supercomputers.

In this work, we present a fully coupled fluid-electro-mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi-physics parallel code, capable of running efficiently in supercomputers. Blood in the cardiac cavities is modeled by the incompressible Navier-Stokes equations and an arbitrary Lagrangian-Eulerian (ALE) scheme. Electrophysiology is modeled with a monodomain scheme and the O'Hara-Rudy cell model. Solid mechanics is modeled with a total Lagrangian formulation for discrete strains using the Holzapfel-Ogden cardiac tissue material model. The three problems are simultaneously and bidirectionally coupled through an electromechanical feedback and a fluid-structure interaction scheme. In this paper, we present the scheme in detail and propose it as a computational cardiac workbench.

New species of Eurycletodes Sars, 1909 and Odiliacletodes Soyer, 1964 from the deep Gulf of California (Copepoda, Harpacticoida, Argestidae).

To date, three species of the family Ancorabolidae, three species of the family Argestidae, and one species of the family Rhizothrichidae are known from the deep sea of the Gulf of California. The descriptions of two new species, Eurycletodes paraephippigersp. n. and Odiliacletodes secundussp. n. collected from the Southern Trough of Guaymas Basin at 1440 m and 1642 m depths, respectively, are presented herein. The closest relatives of these two species, E. ephippiger Por, 1964 and O. gracilis Soyer, 1964 are known from the Mediterranean, but some relatives have been reported also from the southern Atlantic. Eurycletodes paraephippigersp. n. is undoubtedly related to E. ephippiger Por, 1964 known from Israel and Banyuls-sur-Mer (France). These two species can be separated by the armature complement of the basis of the maxillule, by the armature complement of the syncoxa of the maxilliped, and by the relative position of the anal operculum. Odiliacletodes secundussp. n. showed to be closely related to O. gracilis Soyer, 1964 known from Banyuls-sur-Mer only. The latter two species can be separated by the armature complement of the syncoxa of the maxilliped, by the structure of the antenna, and by the inner armature complement of the third exopodal segment of the fourth swimming leg.

New species of the genus Mesocletodes Sars, 1909 from the deep Gulf of California (Copepoda, Harpacticoida).

Investigations on the effects of the oxygen minimum zone on the distribution, abundance, and diversity of deep-sea benthic and pelagic fauna of the Gulf of California and Eastern Tropical Pacific has received attention recently. However, very little is known about the diversity of deep-sea benthic harpacticoids from this region, and only three species, Ancorabolus hendrickxi Gómez & Conroy-Dalton, 2002, Ceratonotus elongatus Gómez & Díaz, 2017 and Dendropsyllus californiensis Gómez & Díaz, 2017, have been described so far. The genus Mesocletodes Sars, 1909 is one of the most common and abundant genera of deep-sea harpacticoids. This genus has been traditionally subdivided into two species groups, the abyssicola and the inermis groups, based on the presence/absence of a dorsal cuticular process on the cephalothorax and anal somite, but some species have been reported to deviate from this scheme. As a result of their investigations, other researchers proposed the monophyly of the abyssicola group, and suggested the probable monophyly of two other species-groups. In this paper, the descriptions of three new species of the genus Mesocletodes from the deep sea of the Gulf of California are presented with some notes on their relationships with other species. Some comments on the monophyly of the genus are given.

A new species of Chondracanthus (Cyclopoida: Chondracanthidae) parasitic on deep-sea Dibranchus spongiosa(Lophiiformes: Ogcocephalidae) from the Eastern Central Pacific.

A total of 228 sampling stations were visited for benthic fauna during a series of oceanographic cruises in the Gulf of California, west coast of the Baja California Peninsula, and Eastern Central Pacific from year 1991 to 2014. Among others, three fish species of the genus Dibranchus were caught in 28 stations. Of these, D. spongiosa was the most common and abundant. Close inspection of this fish revealed the presence of a new species of parasitic copepod, Chondracanthus dibranchi sp. nov., found in the gill cavity of seven specimens of D. spongiosa. Chondracanthus dibranchi sp. nov. seems to be morphologically related to C. psetti and C. janebennettae. The female of C. janebennettae can be separated from these other two congeners by the general shape of the head and abdomen, by the number of teeth on the mandibular blade, and by the general body shape. Chondracanthus psetti and C. dibranchi sp. nov. share the relative lengths of legs 1 and 2, the relative size and shape of the genito-abdomen, and the conical attenuating lateral processes on the trunk of the female. The females of these two species can be separated by the shape and armature of the antennule, shape of the antenna, the claw of the maxilliped, the rami of leg 1 and 2 and posterior processes, the head region, and by the position of the lateral processes of the trunk. An amendment to Tang's (2007) key to the species of Chondracanthus is proposed.

Evaluación del comportamiento del sistema de ajuste locator asociado con una prótesis parcial removible, análisis de elementos finitos / Evaluation of the behavior system locator associated with a removable partial denture, finite element analysis

Objetivo: El propósito de esta investigación fue evaluar el comportamiento del sistema de ajuste locator asociado con una prótesis parcial removible (PPR) con extensión distal inferior por medio del método de análisis de elementos finitos (MEF). Materiales y Métodos: Se diseñó un modelo clase II Kennedy tridimensional utilizando un Software CAD de Solid Works 2010 (SolidWorks Corp., Concord, MA, USA), y posteriormente se procesó y analizó a través Software ANSYS versión 14. Se modelo un (1) implante Tapered Screw-Vent® (ref. TSVB10 Zimmer Dental-Carlsbad, CA, USA) de 10mm de longitud x 3.7mm de diámetro con una plataforma de 3.5mm, de hexágono interno con su respectivo tornillo de fijación; este se ubicó en el diente 37 como pilar posterior de una PPR, cuyo conector mayor fue una barra lingual colada (aleación cromo cobalto), con base combinada (metal/acrílico), con dientes a reemplazar (37, 36 y 35). Se evaluaron los esfuerzos von Mises en una carga 400N. Este análisis permitió valorar el comportamiento de las diferentes estructuras protésicas modeladas y los efectos generados en las interfases hueso-implante. Resultados: Se observaron diferencias entre los valores von Mises en todas las estructuras y ante las cargas no hubo deformaciones permanentes en ninguna de ellas. Estructuras como el hueso mostraron microdeformaciones en valores normales. Conclusiones: El comportamiento de la conexión PPR-implante, mostró una distribución de esfuerzos favorable al utilizar una PPR, sometiéndola a carga en dirección vertical.

Aim: The purpose of this research was to evaluate the behavior of the system locator settings associated with distal extension removable partial denture lower (PPR) by finite element analysis (FEA). Materials and Methods: A Class II Kennedy 3D model using a CAD software Solid Works 2010 (SolidWorks Corp., Concord, MA, USA), and subsequently processed and analyzed by ANSYS Software version Model 14. One (1) was designed implant Tapered Screw -Vent® (ref TSVB10 Zimmer Dental-Carlsbad,CA,USA.) length x 10mm diameter 3.7mm with a 3.5mm platform, internal hexagon with its respective screw fixation; this was located at the tooth 37 as a rear pillar of a PPR, whose major connector was a lingual bar casting (alloy cobalt chromium), based combined (metal/ acrylic) with teeth to replace (37, 36 and 35). Efforts were evaluated von Mises in a 400N load. This analysis allowed assessing the performance of various prosthetic structures modeled and generated effects on bone-implant interface. Results: Differences between the values von Mises in all structures and loads were observed before there was no permanent deformation in any of them. Structures such as bone showed in normal values microstrain Conclusions: The behavior of the PPRimplant connection, showed a favorable distribution efforts by using a PPR, subjecting it to load in the vertical direction