Mast cells (MCs) can release a variety of biologically active mediators under different circumstances, such as fever or vaccination. Our aim was to evaluate the incidence and severity of MC activation symptoms induced by SARS-CoV-2 virus (COVID-19) infection and vaccination in a cohort of 92 pediatric patients with cutaneous mastocytosis. Our findings support previous evidence on the safety of COVID-19 infection and vaccination in patients with MC disorders.
COVID-19 Vaccines , COVID-19 , Mastocytosis, Cutaneous , SARS-CoV-2 , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Cross-Sectional Studies , Retrospective Studies , Vaccination
No disponible
Humans , Female , Middle Aged , Vision Disorders/complications , Vision Disorders/diagnostic imaging , Angioid Streaks/diagnostic imaging , Macular Edema/complications , Macular Edema/diagnostic imaging , Pseudoxanthoma Elasticum/diagnostic imaging , Tomography, Optical Coherence/methods , Skin Diseases/diagnosis , Skin Diseases/surgery , Elastic Tissue/pathology , Pseudoxanthoma Elasticum/complications , Pseudoxanthoma Elasticum/physiopathology
Abstract Acral persistent papular mucinosis (APPM) is a rare subtype of localized lichen myxedematosus. It consists of small papules localized exclusively on the back of the hands, wrists and extensor aspects of distal forearms with no other clinical or laboratory manifestations. The lesions tend to persist and may increase slowly in number. Histologically, hematoxylin-eosin and Alcian blue staining demonstrate mucin accumulation in the upper reticular dermis with separation of collagen fibers as a result of hyaluronic acid deposition. Treatment is rarely necessary due to the absence of symptoms. We present a 27-year-old healthy woman with asymptomatic papules on her upper extremities, which adequately meet clinical and pathological criteria of acral papular mucinosis.
Humans , Female , Adult , Skin/pathology , Skin Diseases/pathology , Scleromyxedema/pathology , Biopsy , Upper Extremity , Rare Diseases , Mucins/analysis
Acral persistent papular mucinosis (APPM) is a rare subtype of localized lichen myxedematosus. It consists of small papules localized exclusively on the back of the hands, wrists and extensor aspects of distal forearms with no other clinical or laboratory manifestations. The lesions tend to persist and may increase slowly in number. Histologically, hematoxylin-eosin and Alcian blue staining demonstrate mucin accumulation in the upper reticular dermis with separation of collagen fibers as a result of hyaluronic acid deposition. Treatment is rarely necessary due to the absence of symptoms. We present a 27-year-old healthy woman with asymptomatic papules on her upper extremities, which adequately meet clinical and pathological criteria of acral papular mucinosis.
Scleromyxedema/pathology , Skin Diseases/pathology , Skin/pathology , Adult , Biopsy , Female , Humans , Mucins/analysis , Rare Diseases , Upper Extremity
No disponible
Adult , Humans , Male , Imaging, Three-Dimensional/instrumentation , Imaging, Three-Dimensional/methods , Vascular Malformations/blood , Vascular Malformations/genetics , Skin Neoplasms/congenital , Skin Neoplasms/genetics , Endothelial Cells/cytology , Nevus/genetics , Imaging, Three-Dimensional/standards , Imaging, Three-Dimensional , Vascular Malformations/complications , Vascular Malformations/metabolism , Skin Neoplasms/metabolism , Skin Neoplasms/pathology , Endothelial Cells/metabolism , Nevus/pathology
No disponible
Humans , Male , Middle Aged , Dermatitis Herpetiformis/pathology , Autoantibodies/immunology , Autoantigens/immunology , Biopsy , Combined Modality Therapy , Dapsone/therapeutic use , Dermatitis Herpetiformis/diagnosis , Dermatitis Herpetiformis/immunology , Dermatitis Herpetiformis/therapy , Diet, Gluten-Free , Fluorescent Antibody Technique, Indirect
Dermatitis Herpetiformis/pathology , Autoantibodies/immunology , Autoantigens/immunology , Biopsy , Combined Modality Therapy , Dapsone/therapeutic use , Dermatitis Herpetiformis/diagnosis , Dermatitis Herpetiformis/immunology , Dermatitis Herpetiformis/therapy , Diet, Gluten-Free , Fluorescent Antibody Technique, Indirect , Humans , Immunoglobulin A/immunology , Male , Middle Aged , Transglutaminases/immunology
Acute Generalized Exanthematous Pustulosis/diagnosis , Fever/etiology , Acute Generalized Exanthematous Pustulosis/complications , Acute Generalized Exanthematous Pustulosis/drug therapy , Azithromycin/administration & dosage , Azithromycin/therapeutic use , Diagnosis, Differential , Drug Therapy, Combination , Female , Humans , Leukocytosis/etiology , Middle Aged , Prednisone/administration & dosage , Prednisone/therapeutic use , Psoriasis/diagnosis
El Carcinoma de Células de Merkel (CCM) es un tumor inusual de rápido crecimiento y potencial metastático, que presenta una mortalidad elevada (30%) y cuya incidencia está en aumento. Principalmente afecta a las personas de avanzada edad, inmunodeprimidos e historia de fotoexposición prolongada. En el 2008 se estableció su asociación con el Poliomavirus de las células de Merkel (MCPyV) lo que ha supuesto un nuevo campo de investigación. Su manejo está en continua discusión ya que la mayoría de las guías se basan en estudios restrospectivos. Presentamos un caso de CCM en mejilla derecha, en una paciente de 85 años. Esta revisión pretende actualizar los conocimientos de este tumor poco frecuente pero muy agresivo (AU)
The Merkel cell carcinoma (MCC) is an unusual, rapidly growing tumour and potentially metastatic, presenting a high mortality rate (30%), and whose incidence is increasing. It mainly affects people of advanced age, immunodepressed, and with a history of prolonged exposure to the sun. In 2008, an association with Merkel cell polyomavirus (MCPyV) was established, which has led to a new field of research. Its management is under continuous discussion, as most guidelines are based on retrospective studies. We report a case of MCC on the right cheek, in an 85 year old patient. The aim of this report is to update knowledge of this uncommon but very aggressive tumour (AU)
Humans , Female , Aged, 80 and over , Carcinoma, Merkel Cell/complications , Carcinoma, Merkel Cell/diagnosis , Carcinoma, Merkel Cell/therapy , Polyomavirus/immunology , Polyomavirus/isolation & purification , Polyomavirus/pathogenicity , Immunohistochemistry/methods , Immunohistochemistry , Carcinoma, Merkel Cell/physiopathology , Carcinoma, Merkel Cell
