RESUMEN
We studied the effect of corticotropin-like intermediate lobe peptide (CLIP) on presynaptic NMDA receptors and postsynaptic GABA, NMDA, and AMPA receptors in rat brain. CLIP inhibited presynaptic and postsynaptic NMDA receptors, but potentiated postsynaptic GABA and AMPA receptors. Our results indicate that CLIP modulates function of ionotropic receptors for glutamate and GABA.
Asunto(s)
Péptido de la Porción Intermedia de la Adenohipófisis Similar a la Corticotropina/farmacología , Receptores de GABA/efectos de los fármacos , Receptores de Glutamato/efectos de los fármacos , Animales , Animales Recién Nacidos , Técnicas de Placa-Clamp , Terminales Presinápticos/efectos de los fármacos , Ratas , Ratas Wistar , Receptores AMPA/efectos de los fármacos , Receptores de N-Metil-D-Aspartato/efectos de los fármacos , Transmisión Sináptica/efectos de los fármacosRESUMEN
We studied the effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors. L,D-Dipeptide more potently than L,L-dipeptide inhibited postsynaptic NMDA receptors, potentiated GABA and AMPA receptors, and inhibited (45)Ca(2+) uptake in synaptosomes from of rat brain cortex. Our results indicate that muramyl dipeptides modulate function of glutamate and GABA receptors.
