[Reconstructing habitat history of Larimichthys polyactis in Lüsi coastal waters of Jiangsu Province, China based on otolith microchemistry].

An electron probe microanalyzer (EPMA) was applied to analyze the element Sr and Ca microchemistry patterns in otoliths of Larimichthys polyactis in Lüsi coastal waters of Jiangsu Province, China. The results showed that Sr was heterogeneously distributed along the sagittal plane of the otoliths. The highest Sr concentration was normally found in the otolith cores while much lower concentrations were found in the remaining areas. The corresponding Sr/Ca ratios were (7.10 +/- 1.00) and (4.79 +/- 1.01) in the former and latter, respectively, which were significantly differed (P < 0.01), but low Sr/Ca ratios even as low as (3.51 +/- 0.76) were also observed in several fish. Based on the above results of otolith microchemistry, the habitat history of L. polyactis was reconstructed as that high salinity habitats seemed to be required at the stages of hatching and post-hatching development, while the reduced salinity habitats seemed to be preferable for the growth and development at the remaining stages of the life history. Furthermore, several fish in this study had likely even experienced much lower salinity habitats at the early stages.

[A controlled study on the treatment of acute progressive cerebral infarction by continuous anticoagulation with small doses of heparin].

OBJECTIVE: To discuss the treatment of acute progressive cerebral infarction by continuous anticoagulation with small doses of heparin. METHODS: A prospective, randomized, and controlled clinical research was conducted. Three hundred and fifty-one patients were randomly divided into three groups. Group A (n=119) was treated with heparin, which was controlled by an infusion pump with a speed of 18 U×kg(-1)×h(-1) for 24 hours, and the dosage was regulated according to the changes in activated partial thromboplastin time (APTT) which was determined every 8 hours. Group B (n=115) was treated with intravenous drip of 12,500 U of heparin with a speed of 18 U×kg(-1)×h(-1) once a day. Group C (n=117) was treated with 5000 U of low-molecular-weight heparin calcium injection twice a day. After 14 days, nerve function defect according to the National Institutes of Heath stroke scale (NIHSS) score was determined, the adverse events (e.g. intracranial hemorrhage, subcutaneous ecchymosis, gingival bleeding, hematuria and occult blood in stools) were observed. After 6 months, the recurrence rate and Barthel index (BI) would be determined. RESULTS: The total efficiency in group A (95.80%) was significantly higher than that in group B (85.22%) and group C (85.47%). Recurrence rate in group A (1.68%) was significantly lower than group B (8.70%) and group C (8.33%) with significant differences (P<0.05 or P<0.01), while there was no significant difference between group B and group C (both P>0.05). The BI of group A (89.27±8.56) was significantly higher than group B (72.57±9.77) and group C (71.66±9.37) with significant difference (both P<0.01), while there was no significant difference between group B and group C (P>0.05). Adverse event rate in group A (5.88%) was slightly higher than that of group B (3.48%) and group C (4.27%), but the difference was not significant (both P>0.05). CONCLUSIONS: Continuous infusion of low dosage of heparin could significantly reduce neurologic impairment score in patients with progressive cerebral infarction, increase cure rate, reduce the recurrence rate, and raise the BI of patients, and it dose not increase the risk of intracranial and extracranial hemorrhage.