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Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.

Adler, Frederick R; Anderson, Alexander R A; Bhushan, Abhinav; Bogdan, Paul; Bravo-Cordero, Jose Javier; Brock, Amy; Chen, Yun; Cukierman, Edna; DelGiorno, Kathleen E; Denis, Gerald V; Ferrall-Fairbanks, Meghan C; Gartner, Zev Jordan; Germain, Ronald N; Gordon, Deborah M; Hunter, Ginger; Jolly, Mohit Kumar; Karacosta, Loukia Georgiou; Mythreye, Karthikeyan; Katira, Parag; Kulkarni, Rajan P; Kutys, Matthew L; Lander, Arthur D; Laughney, Ashley M; Levine, Herbert; Lou, Emil; Lowenstein, Pedro R; Masters, Kristyn S; Pe'er, Dana; Peyton, Shelly R; Platt, Manu O; Purvis, Jeremy E; Quon, Gerald; Richer, Jennifer K; Riddle, Nicole C; Rodriguez, Analiz; Snyder, Joshua C; Lee Szeto, Gregory; Tomlin, Claire J; Yanai, Itai; Zervantonakis, Ioannis K; Dueck, Hannah.

Cell Syst ; 14(4): 252-257, 2023 04 19.

Article En | MEDLINE | ID: mdl-37080161

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.

Mass Behavior , Neoplasms , Humans , Communication