Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review.

Endocrine-disrupting compounds are chemicals that alter the normal functioning of the endocrine system of living organisms. They can be natural (N-EDCs) or synthetic compounds (S-EDCs). N-EDCs can belong to different groups, such as phytoestrogens (PEs), including flavonoids, or mycotoxins originating from plants or fungi, and cyanotoxins, derived from bacteria. Humans encounter these substances in their daily lives. The aim of this rapid review (RR) is to provide a fine mapping of N-EDCs and their toxicological effects on human health in terms of various medical conditions or adverse consequences. This work is based on an extensive literature search and follows a rigorous step-by-step approach (search strategy, analysis strategy and data extraction), to select eligible papers published between 2019 and 2023 in the PubMed database, and to define a set of aspects characterizing N-EDCs and the different human target systems. Of the N-EDCs identified in this RR, flavonoids are the most representative class. Male and female reproductive systems were the targets most affected by N-EDCs, followed by the endocrine, nervous, bone and cardiovascular systems. In addition, the perinatal, pubertal and pregnancy periods were found to be particularly susceptible to natural endocrine disruptors. Considering their current daily use, more toxicological research on N-EDCs is required.

How can we manage the COVID-19 infodemics? A case study targeted to health workers in Italy.

INTRODUCTION: The Istituto Superiore di Sanità (ISS) has been asked for rapid technical and scientific advice to the State and Regions during Sars-CoV-2 pandemic preparedness. METHODS: An ad hoc Working Group on Scientific Literature updates (WG SL) was set up at ISS (March-May 2020) to screen pre-prints and peer reviewed papers from arXiv, medRxiv, bioRxiv, and Pubmed to provide a real time knowledge and empirical evidence addressed to health-workers. RESULTS: The WG SL screened a total of 4,568 pre-prints and 15,590 peer reviewed papers, delivered as daily summary report of pre-print selection for ISS President activity in the National Scientific Technical Committee framework and a weekly open access publication (COVID Contents) on peer-reviewed papers of interest for health professionals, monitored by a satisfaction questionnaire. CONCLUSIONS: Promoting heath literacy, with a cross-cutting approach is a powerful heritage of Public Health Institutes and a proven effective non pharmacological intervention.

[Mobile applications for the health sector: apps to support scientific information and medical practice]. / Iniziative "mobili" a supporto della salute: le app per l'informazione scientifica e la pratica medica.

The market of mobile applications (apps) and wireless technology infrastructures is rapidly widening and diversifying to better meet users' needs. Over the last few years, the use of mobile technologies and applications has been increasingly expanding in many professional fields. Research and academic institutions, hospitals, and drug companies are heavily investing in this sector, also in Italy, even though the offer seems to be still limited at the moment. As far as the industry of scientific publishing is concerned, the main Italian publishing groups show an increasing interest in developing apps aiming at spreading their own products, following the example of international publishing companies. The purpose of this paper is to provide a general overview of the mobile applications and services available in the domain of scientific information relating to health disciplines and medical practice, especially within the Italian context. This study intends to inform professionals and users in the health sector about the benefits offered by the mobile technology, and to help them to become familiar with these tools. The two main online markets (iTunes and Google Play) have been analysed; search engines for apps and Italian STM publishers' websites have also been considered. Within this fast moving scenery, innovation is supported by the pressing demand for mobile access technology which has increased enormously. Not surprisingly, the most promising target of mobile technology is represented by scientific information tools relating to health.