[Analysis of factors affecting the compliance with medical therapy for benign prostatic hyperplasia].

AIM: To investigate factors affecting the compliance of patients with the combination therapy for benign prostatic hyperplasia. MATERIALS AND METHODS: Four hundred BPH outpatients treated with combination therapy were surveyed. RESULTS: The absolute majority of patients (76.16%) expected a quick positive result. 10.47% viewed their disease as too advanced, did not believe in the effectiveness of medical therapy and believed the surgery to be the only treatment option. 24.42% of patients changed the medication dosage on their own, and 11% were ready to discontinue the treatment without consulting their doctors. 76.16% of patients considered the recommended treatment to be effective, 77.33% fully trusted the doctor. In the opinion of 8.7% of patients, the doctor did not sufficiently inform them about the prescribed drug. 22.67% of patients had doubts about a physicians competence, and 5.23% believed the doctor complicated their medical treatment and changed prescriptions too often. CONCLUSIONS: The patients had a high level of trust in doctors and showed psychological adherence to therapy. However, about a quarter of patients changed the treatment regimen on their own. Many patients had exaggerated expectations of the treatment. 8% of patients reported insufficient awareness regarding the nature and appropriateness of drug therapy, and one in five patients had difficulties in perceiving, remembering and following the treatment regimen. CONCLUSION: streamlining therapeutic regimens, prescribing non-titratable or combined drugs will help improve patients therapy compliance.

Circadian rhythms of in vitro incorporation of 3H-melatonin into organs of the hypothalamic-pituitary-thyroid system in rats.

Circadian rhythms of the intensity of 3H-melatonin absorption by organs of the hypothalamic-pituitary-thyroid system were studied in young mature male Wistar rats in summer. The hypothalamus, pituitary, and thyroid gland incorporated 3H-melatonin during the day and night hours, but the intensity of its incorporation in the pituitary and thyroid was high during daytime and low at night, while absorption of the hormone by the hypothalamus tended to be higher at night.