RESUMEN
This study analyzed the fabrication and characterization of polybenzoxazine/polydopamine/ceria as tertiary nanocomposites. To this end, a new benzoxazine monomer (MBZ) was fabricated based on the well-known Mannich reaction of naphthalene-1-amine, 2-tert-butylbenzene-1,4-diol and formaldehyde under ultrasonic-assisted process. Polydopamine (PDA) was used as dispersing polymer nanoparticles and surface modifier for CeO2 by in-situ polymerization of dopamine with the assistance of ultrasonic waves. Then, nanocomposites (NC)s were manufactured by in-situ route under thermal conditions. The FT-IR and 1H-NMR spectra confirmed the preparation of the designed MBZ monomer. The FE-SEM and TEM results showed the morphological aspects of prepared NCs and illustrated the distribution of CeO2 NPs in the polymer matrix. The XRD patterns of NCs showed the presence of crystalline phases of nanoscale CeO2 in an amorphous matrix. The TGA results reveal that the prepared NCs are classified as thermally stable materials.
RESUMEN
N6-methyladenosine (m6A) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of m6A readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/ß-catenin is an evolutionarily conserved signaling pathway that has recently been linked to the pathogenesis of many cancers. Given the significance of this pathway in regulating normal tissue homeostasis and stem cell differentiation, a subtle understanding of the molecular mechanism underlying its dysregulation is required for effective targeting. There is mounting evidence that m6A regulators are highly implicated in the dysregulation of the Wnt/ß-catenin signaling pathway. Since m6A regulators can affect Wnt pathway components and dysregulation of either leads to carcinogenesis, this study aims to clarify the relationship between m6A regulators and the Wnt/ß-catenin signaling pathway to investigate their combined impact on tumorigenesis.