[Results of antioxidant therapy for non-proliferative diabetic retinopathy in patients with type 2 diabetes mellitus].

Diabetes mellitus is associated with dangerous vascular complications, including diabetic retinopathy (DR), which can lead to complete visionloss. Modern diagnostic methods, such as optical coherent tomography, help accurately and objectively verify the stage of DR, thus providing an opportunity to choose a treatment algorithm able to prevent further progression of the disease. The aim of the study was to investigate the efficacy of antioxidant therapy (Vitrum Vision Forte and Vitrum Memory) as the initial phase of treatment of non-proliferative DR in type 2 diabetes, what is pathogenically reasonable due to involved oxidative stress.

[Kallikrein-kinin system as a target for diabetic retinopathy treatment].

Multifactor etiology of diabetic retinopathy (DR) determines difficulty of understanding of pathogenesis and need of search of effective approaches to study key mechanisms of development of this microvascular complication of diabetes mellitus (DM). Significant achievements of the last years show the contribution of two proteolytic systems into pathogenesis of DR, that control vascular tone and permeability - kallikrein-kinin (KKS) and renin-angiotensin systems (RAS). Among new approaches to DR treatment one of the most appropriate is an influence on KKS by means of inhibiting kallikrein, that leads to reduction of retinal vascular permeability and allows to prevent the development of macula oedema and other consequences of vascular wall damage in DR.