[Comparative study of the action of Finoptin, Korinfar and Capoten in patients with stage II hypertensive disease]. / Sravnitel'noe izuchenie aktivnosti finoptina, korinfara i kapotena u bol'nykh gipertonicheskoi bolezn'iu vtoroi stadii.

The effects of Finoptin, Corinfar, and Capoten were examined in 154 patients with Stage II hypertensive disease. The calcium antagonists Finoptin and Corinfar, as well as Capoten were equal in lowering blood pressure and having a heterodirectional action on cardiodynamics: Finoptin exerted a positive inotropic effect in 46.3% and a negative one in 53.7%, corinfar in 66.7 and 33.3%, respectively, and Capoten in 37.5 and 62.5%. The baseline hemodynamic type fails to predict how the myocardium in a particular patient will respond to the antihypertensive drug. Nevertheless, Corinfar is more preferable in patients with hypertensive disease attended by hypokinetic circulation, Capoten is more preferable in those with its hyperkinetic variant. The baseline hemodynamic type makes an insignificant contribution to the activity of Finoptin.

[Comparison of the hemodynamic effects of Corinfar in patients with neurocirculatory dystonia and hypertensive disease]. / Sravnitel'noe vliianie korinfara na gemodinamiku u bol'nykh neirotsirkuliatornoi distoniei i gipertonicheskoi bolezn'iu.

Echocardiography was used to study the cardio- and hemodynamic effects of corinfar in 22 patients with neurocirculatory dystonia and 24 with hypertensive disease. The agent showed a pronounced hyperdynamic effect in patients with neurocirculatory dystonia, whereas it significantly lowered systolic, diastolic, mean blood pressures in those with hypertensive disease, by facilitating left ventricular performance without hyperkinemia. It is concluded that neurocirculatory dystonia and hypertensive disease are different diseases, by judging from the cardio- and hemodynamic effects of the calcium antagonist in these patients.

[The hemodynamic reactions of hypertension patients taking the calcium antagonists finoptin and korinfar]. / Gemodinamicheskie reaktsii u bol'nykh gipertonicheskoi bolezn'iu na priem antagonistov kal'tsiia finoptina i korinfara.

As many as 98 patients suffering from essential hypertension (EH) were examined for the effects of verapamil and nifedipine. The hemodynamics and heart contractility were estimated by means of echocardiography on an "Aloka D-280" outfit (Japan). The following parameters of the cardio- and hemodynamics were computed: the stroke and minute blood volumes, cardiac index, mean velocity of ventricular evacuation, performance of the left heart, energy consumption by the myocardium, arterial pressure (systolic, diastolic and mean), total peripheral vascular resistance, ejection fraction, and the rate of circulatory shortening of myocardial fibers. Analysis of the effects of verapamil and nifedipine on the cardio- and hemodynamics in EH patients has demonstrated that in addition to their unidirectional action manifested by a steady hypotensive effect, the drugs under consideration produced an action of different directions as regards certain essential parameters in a considerable number of the patients.

[Evaluation of the effect of obsidan in essential hypertension patients with different types of circulation]. / Otsenka deistviia obzidana u bol'nykh gipertonicheskoi bolezn'iu s razlichnymi tipami krovoobrashcheniia.

A study of the effect of propranolol on the central hemodynamics using the polycardiographic method in 90 patients with essential hypertension showed that in 83% of them, disregarding the type of hemodynamics, beta-blocker made a negative chronotropic effect, and in 17% of the patients it increased the heart rate. In the patients with the hyperkinetic circulation the negative inotropic effect of propranolol was noted in 42% of the cases, and in the patients with the eu- and hypokinetic circulation 37.5%. However, the improvement of myocardial contractility expressed in an increase in the cardiac and stroke blood volume, the stroke and cardiac indices, and a decrease in peripheral vascular resistance were found in 24.4% of the total number of patients.

[Characteristics of hemodynamics in patients with incipient and marked arterial hypertension]. / Osobennosti gemodinamiki u bol'nykh nachal'noi i vyrazhennoi arterial'noi gipertoniei.

The examination of the cardio-and hemodynamics in 22 patients with neurocirculatory dystonia of the hypertonic type and in 50 patients with stable hypertension showed that in the first group patients the systolic pressure in the pulmonary artery was increased due to hyperactivity whereas in individuals with stable hypertension it did not exceed normal values. A high load on the left ventricle in patients with high hypertension serves as an inotropic factor delaying the decompensation of the left ventricle.

[Significance of progesterone in the pathogenesis and treatment of pulmonary hypertension and cardiopulmonary failure]. / Znachenie progesterona v patogeneze i lechenii legochnoi gipertonii i legochno-serdechnoi nedostatochnosti.

Study of blood progesterone and diurnal urine pregnanediol revealed that progesterone level substantially increased in the initial stage of cor pulmonale formation (in respiratory failure without heart decompensation). Meanwhile as heart insufficiency and pulmonary hypertension in patients with chronic nonspecific lung diseases augmented, blood progesterone and excretion of pregnanediol dramatically fell. Application of progesterone (2.5% solution, 2 ml i.m. once a day over a week) favoured an increase in pulmonary ventilation, improvement of myocardial contractility, and pressure drop in the pulmonary artery.