Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 53
Filtrar
1.
Front Neurol ; 15: 1284038, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38872820

RESUMEN

Background: Falcotentorial meningiomas (FM) are surgical challenges for protecting sinus, and the technique notes on the management of superior sagittal or transverse sinus are required for good results. Methods: We improved the technique notes on the management of superior sagittal or transverse sinus in three FM patients with signs of increased intracranial pressure or chronic headache. Results: All patients underwent surgeries in the prone position, and occipital/sup-occipital/sub-occipital craniotomy was performed. In one patient, the skull was removed traditionally with exposure of the confluence of sinuses, superior sagittal, and transverse sinus, while the longitudinal skull bridge was left to suspend the dura for protecting the superior sagittal sinus in one patient, and the transverse skull bridge was left to suspend the dura for protecting the transverse sinus in one patient. The dura was opened infratentorially or supratentorially to spare the sinus and then the "skull bridge" was suspended. The tumor was then removed completely without brain swelling or significant venous bleeding. Complete tumor resection was confirmed by early postoperative imaging, and all patients recovered well without postoperative morbidity. Conclusion: The authors recommend the "skull bridge" to suspend the dura for optimal control of the venous sinuses during FM surgery (less venous bleeding).

2.
AIDS ; 38(5): 713-721, 2024 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-38016165

RESUMEN

OBJECTIVE: We aimed to explore the effect of particulate matter exposure on renal function in people with HIV/AIDS (PWHA). METHODS: A total of 37 739 repeated measurements were conducted on eGFR levels, serum creatinine (Scr), and the triglyceride-glucose (TyG) index in 6958 PWHAs. The relationship between 1 and 28 day moving averages of particulate matter concentrations with Scr and eGFR was assessed using linear mixed-effects models. Modified Poisson regression models were employed to assess the associations of cumulative particulate matter exposure with the incidence of chronic kidney disease (CKD). Mediation analyses were used to examine the role of TyG index. RESULTS: Short-term exposure to particulate matter was related to reduced renal function. The strongest associations between exposure to particulate matter (PM) 1 , PM 2.5 , and PM 10 and percentage changes in eGFR were observed at 7-day moving average exposure windows, with a respective decrease of 0.697% (-1.008%, -0.386%), 0.429% (-0.637%, -0.220%), and 0.373% (-0.581%, -0.164%) per IQR increment. Long-term exposure to PM 1 , PM 2.5 , and PM 10 was positively linked with the incidence of CKD, with each IQR increment corresponding to fully adjusted RRs (95% CIs) of 1.631 (1.446-1.839), 1.599 (1.431-1.787), and 1.903 (1.665-2.175), respectively. TyG index-mediated 8.87, 8.88, and 7.58% of the relationship between cumulative exposure to PM 1 , PM 2.5 , and PM 10 and increased risk of CKD, respectively. CONCLUSION: Exposure to particulate matter among PWHAs is linked to reduced renal function, potentially contributing to increased CKD incidence, where the TyG index might serve as a partial mediator.


Asunto(s)
Síndrome de Inmunodeficiencia Adquirida , Contaminantes Atmosféricos , Contaminación del Aire , Infecciones por VIH , Insuficiencia Renal Crónica , Insuficiencia Renal , Humanos , Material Particulado/efectos adversos , Material Particulado/análisis , Contaminantes Atmosféricos/efectos adversos , Contaminantes Atmosféricos/análisis , Contaminación del Aire/efectos adversos , Contaminación del Aire/análisis , Infecciones por VIH/complicaciones , Insuficiencia Renal Crónica/epidemiología , Insuficiencia Renal/inducido químicamente , Riñón
3.
Macromol Rapid Commun ; 44(24): e2300371, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37657922

RESUMEN

Polyamide 56 (PA56) has gained significant attention in the academic field due to its remarkable mechanical and thermal properties as a highly efficient and versatile biobased material. Its superior moisture absorption property also makes it a unique advantage in the realm of fiber textiles. However, despite extensive investigations on PA56's molecular and aggregate state structure, as well as processing modifications, little attention has been paid to its polymerization mechanism. Herein, the influence of temperature and time on PA56's polycondensation reaction is detailed studied by end-group titration and carbon nuclear magnetic resonance (NMR) techniques. The reaction kinetics equations for the pre-polymerization and vacuum melt-polymerization stages of PA56 are established, and possible side reactions during the polycondensation process are analyzed. By optimizing the reaction process based on kinetic characteristics, PA56 resin with superior comprehensive properties (melting temperature of 252.6 °C, degradation temperature of 371.6 °C, and tensile strength of 75 MPa) is obtained. The findings provide theoretical support for the industrial production of high-quality biobased PA56.


Asunto(s)
Nylons , Nylons/química , Polimerizacion , Temperatura
5.
Macromol Rapid Commun ; 44(3): e2200644, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36404053

RESUMEN

The thermal stability and reactivity of organophosphorus flame-retardants play a critical role in synthesizing copolymerized flame-retardant polyamides. Herein, this work successfully synthesizes a flame-retardant CEPPA-DDA salt (CDS) with both good thermal stability and high reactivity by reacting 2-carboxyethyl phenyl phosphonic acid (CEPPA) with 1,12-dodecanediamine (DDA). Flame-retardant polyamide 1210 (FRPA) is further prepared by copolymerizing the CDS, DDA, and sebacic acid (SEA). The test results show that the introduction of CDS can significantly improve the flame-retardant properties of FRPA. Specifically, the flame-retardant polyamide 1210 (FRPA-7) with 7 wt% CDS addition can reach V-0 grade according to UL-94 standard, accompanying limiting oxygen index value of 30.2% and tensile strength of 38.62 MPa. Compared with pure polyamide 1210, the peak heat release rate and total heat release rate of FRPA-7 reduce by 24.11% and 9.40%, respectively. This study provides a simple strategy to prepare flame-retardant polyamides with high flame retardancy and good mechanical properties, which are expected to show great potentials in future industrial applications.


Asunto(s)
Nylons , Fósforo , Cloruro de Sodio , Calor , Nitrógeno , Polímeros
6.
Medicine (Baltimore) ; 101(47): e32042, 2022 Nov 25.
Artículo en Inglés | MEDLINE | ID: mdl-36451503

RESUMEN

BACKGROUND: To fully understand the clinical features and prognosis of Glioblastoma (GBM), we extracted the data from the Surveillance, Epidemiology, and End Results (SEER) database and performed a series of analyses. METHODS: We retrospectively analyzed the data of 1674 patients with GBM obtained from the SEER database from 1983 to 2015. Kaplan-Meier analysis was performed to calculate the survival rate, and the log-rank test was used to analyze the survival outcomes. RESULTS: Older patients with GBM had a worse survival period (P < .05). Laterality had no effect on the prognosis (P > .05). Patients with high-grade gliomas may have a shorter lifespan (P < .05). In terms of overall survival (OS) and disease specificity, all 3 classical treatments failed to improve the life expectancy (P > .05). In adult patients with GBM, we found that age, tumor grade, surgery, radiotherapy, and chemotherapy were independent risk factors for all-cause mortality. In the univariate disease-specific analysis, age, tumor grade, surgery, radiotherapy, and chemotherapy were independent risk factors. However, in multivariate disease-specific analysis, the results showed that only tumor grade and surgery were independent risk factors for GBM. CONCLUSIONS: Older patients diagnosed with GBM have worse survival, and patients with glioma of higher grades have a shorter lifespan. Age, grade, surgery, radiation therapy, and chemotherapy were independent prognostic factors for patients with GBM.


Asunto(s)
Glioblastoma , Glioma , Adulto , Humanos , Glioblastoma/terapia , Estudios Retrospectivos , Pronóstico , Análisis de Supervivencia
7.
Adv Mater ; 34(43): e2108619, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-36055645

RESUMEN

The development of highly efficient non-precious metal electrocatalysts for the oxygen evolution reaction (OER) in low-grade or saline water is currently of great importance for the large-scale production of hydrogen. In this study, by using an electrochemical activation pretreatment, metal oxy(hydroxide) nanosheet structures derived from self-supported nickel-iron phosphide and nitride nanoarrays grown on Ni foam are successfully fabricated for OER catalysis in saline water. It is demonstrated that the different NiOOH and NiOOH@FeOOH (NiOOH grown on FeOOH) structures are generated from nickel-iron nitride and phosphide, respectively, after electrochemical activation. In particular, the NiOOH@FeOOH heteroarchitecture shows outstanding electrocatalytic performance with an ultralow overpotential of 292 mV to drive the current density of 500 mA cm-2 . An unconventional dual-sites mechanism (UDSM) is proposed to address the OER process on NiOOH@FeOOH and show that the FeOOH underlayer plays a critical role regarding the enhanced OER activity of NiOOH. The new possible UDSM involving two reaction sites presents a different understanding of the OER process on multi-OH layer complexes, which is expected to guide the design of heteroarchitecture electrocatalysts.

8.
Front Neurol ; 13: 719778, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35449518

RESUMEN

Backgrounds: Although there are a certain number of studies dedicated to the disturbances of the dopaminergic system induced by traumatic brain injury (TBI), the associations of abnormal dopaminergic systems with post-traumatic anxiety and depressive disorders and their underlying mechanisms have not been clarified yet. In the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (SN) and the ventral tegmental area (VTA). Thus, we selected SN and VTA as regions of interest and performed a seed-based global correlation to evaluate the altered functional connectivity throughout the dopaminergic system post-TBI. Methods: Thirty-three individuals with TBI and 21 healthy controls were recruited in the study. Anxiety and depressive symptoms were examined by the Hospital Anxiety and Depression Scale. All MRI data were collected using a Siemens Prisma 3.0 Tesla MRI system. The volume of SN and the global functional connectivity of the SN and VTA were analyzed. Results: In the present study, patients with TBI reported more anxiety and depressive symptoms. More importantly, some structural and functional alterations, such as smaller SN and reduced functional connectivity in the left SN, were seen in individuals with TBI. Patients with TBI had smaller substantia nigra on both right and left sides, and the left substantia nigra was relatively small in contrast with the right one. Among these findings, functional connectivity between left SN and left angular gyrus was positively associated with post-traumatic anxiety symptoms and negatively associated with depressive symptoms. Conclusions: The TBI causes leftward lateralization of structural and functional alterations in the substantia nigra. An impaired mesocortical functional connectivity might be implicated in post-traumatic anxiety and depression.

9.
World Neurosurg ; 160: e152-e158, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-34979288

RESUMEN

OBJECTIVE: To explore the feasibility of using a modified power-on programming method in deep brain stimulation (DBS) for Parkinson disease (PD). METHODS: We conducted a retrospective cohort study including 151 PD patients with bilateral robot-assisted DBS surgery from July 2017 to June 2020. Ninety-seven patients were adopted to the modified power-on programming method (Group I) and 54 patients were adopted to the traditional power-on programming method (Group II). In one-year follow-up, power-on programming duration, stimulation parameters, scores of Unified PD Rating Scale (UPDRS) and UPDRS-III of the 2 groups were recorded and compared. RESULTS: There were no significant differences in the postoperative UPDRS, UPDRS-III improvement rate, and stimulation parameters between the 2 groups. The duration of power-on programming of Group I (1.7 ± 1.1 hours) was significantly less than that of Group II (3.5 ± 1.8 hours, P < 0.0001). CONCLUSIONS: The modified power-on programming method can achieve a similar clinical effect to the traditional method, with the advantage of more efficiency.


Asunto(s)
Estimulación Encefálica Profunda , Enfermedad de Parkinson , Núcleo Subtalámico , Estimulación Encefálica Profunda/métodos , Humanos , Enfermedad de Parkinson/terapia , Estudios Retrospectivos , Núcleo Subtalámico/cirugía , Resultado del Tratamiento
10.
Chemphyschem ; 23(3): e202100753, 2022 Feb 04.
Artículo en Inglés | MEDLINE | ID: mdl-34821003

RESUMEN

CO is a key intermediate during electrochemical CO2 conversion. The deep reduction of CO to value-added chemical products is a crucial strategy for effective carbon utilization. Single transition metal atoms supported by two-dimensional material present a novel paragon for various catalytic reactions. Herein, we employ first principle theory to study a series of single 3d-transition metal atoms supported by monolayered MoS2 with S vacancy as efficient electrocatalyst for CO electroreduction to CH4 . The screening result indicates that Cr doped defective MoS2 (labeled as Cr/Sv -MoS2 ) is beneficial to electroreduction of CO to CH4 , with even less negative limiting potential (-0.32 V) than Cu that has been widely studied as the most promising electrocatalyst in experiment. The outstanding activity is derived from the regulation of the d-band-center of doped Cr and Mo atoms exposed on the surface. This discovery provides a theoretical basis for the preparation of future electrocatalysts for CORR.

11.
Demography ; 59(1): 247-266, 2022 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-34807249

RESUMEN

Despite extensively examining the effects of family policies on marriage and fertility rates, previous research has paid little attention to the process of policy implementation and has implicitly assumed that individuals are fully aware of the policy information when making marital and fertility decisions. Challenging this assumption, we theorize policy awareness as an important mechanism for understanding the potential influence of family policies on individuals' marital intentions, an understudied yet crucial determinant of family formation behavior. In an experiment using a national survey of young unmarried individuals in Japan, respondents were randomly assigned to treatment and control groups. The treatment group was informed about 17 Japanese family policy benefits, but most of the respondents knew none or only a few of these benefits. After exposure to the policy information, the treatment group had significantly higher marital intentions than the control group, which had similar baseline characteristics but no information exposure. Crucially, such positive effects were particularly pronounced among high-educated women and high- and low-educated men, reflecting the differentiated effects of policy awareness under Japan's traditional gender role norms. Overall, these findings highlight the pivotal role of policy awareness during the family formation process and contribute to the debate over whether and how family policies may influence different subpopulations.


Asunto(s)
Política de Planificación Familiar , Tasa de Natalidad , Femenino , Fertilidad , Humanos , Intención , Masculino , Matrimonio , Dinámica Poblacional
12.
ACS Nano ; 16(1): 522-532, 2022 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-34939416

RESUMEN

Engineering the morphology and electronic properties simultaneously of emerging metallene materials is an effective strategy for enhancing their performance as oxygen reduction reaction (ORR) electrocatalysts. Herein, a highly efficient and stable ORR electrocatalyst, Fe-doped ultrathin porous Pd metallene (Fe-Pd UPM) composed of a few layers of 2D atomic metallene layers, was synthesized using a simple one pot wet-chemical method and characterized. Fe-Pd UPM was measured to have enhanced ORR activity compared to undoped Pd metallene. Fe-Pd UPM exhibits a mass activity of 0.736 A mgPd-1 with a loss of mass activity of only 5.1% after 10 000 cycles at 0.9 V versus the reversible hydrogen electrode (vs RHE) in 0.1 M KOH solution. Density functional theory (DFT) calculations reveal that the stable Fe dopant in the inner atomic layers of Fe-Pd UPM delivers a much smaller overpotential during O* hydrogenation into OH*. The morphology, porous structure, and Fe doping were verified to have enhanced ORR activity. We believe that the rational design of metallene materials with porous structures and interlayer doping is promising for the development of efficient and stable electrocatalysts.

13.
Eur Neurol ; 84(5): 340-347, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34182550

RESUMEN

INTRODUCTION: Memory impairment and mood disorders are among the most troubling sequelae following traumatic brain injury (TBI). The relationships between comorbid psychiatric disorders and memory function have not been well illustrated. The aim of the study was to explore the relationships of comorbid anxiety and depressive symptoms with memory function following TBI. METHODS: A total of 46 TBI participants across all levels of injury and 23 healthy controls were enrolled in this case-control study. Wechsler Memory Scale-Chinese Revision (WMS-CR) picture, recognition, associative learning, comprehension memory, and digit span were administered to evaluate several categories of memory capacity. The Hospital Anxiety and Depression Scale (HADS) was employed to evaluate the anxiety and depressive symptoms. Stepwise multiple linear regressions were conducted. RESULTS: Compared to healthy controls, the participants with TBI reported more anxiety and depressive symptoms. In the meanwhile, they performed more poorly on memory tests, showing 1.84 SDs, 1.07 SDs, and 0.68 SDs below healthy participants on visuospatial memory, working memory, and verbal memory, respectively. A variety of variables, including HADS depression, HADS anxiety, age, GCS, and education were associated with posttraumatic memory function in the bivariate models. The stepwise multiple linear regressions demonstrated a negative association between HADS depression and posttraumatic memory function, especially performance on visuospatial and verbal memory and a positive association between education and posttraumatic memory function. CONCLUSION: More depressive symptoms rather than anxiety symptoms and less years of education are significant predictors for posttraumatic memory dysfunction.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Depresión , Ansiedad/epidemiología , Ansiedad/etiología , Trastornos de Ansiedad , Lesiones Traumáticas del Encéfalo/complicaciones , Estudios de Casos y Controles , Depresión/epidemiología , Depresión/etiología , Humanos
14.
Artículo en Inglés | MEDLINE | ID: mdl-33440737

RESUMEN

Social capital in immigrants has drawn considerable attention from social scientists. Previous studies have paid attention to how immigrants' bonding social capital (defined as social networks with co-ethnic residents) and bridging social capital (defined as social networks with native residents) are associated with their economic achievement. However, little attention has been paid to immigrants' different social capital's effects on psychological well-being. Drawing data from Chinese immigrants in Japan, we examined how these Chinese immigrants assimilated into Japanese society and how their bonding and bridging social capital related to their psychological well-being. The results show that bonding social capital directly affected immigrants' psychological well-being, whereas bridging social capital indirectly improved their psychological well-being by improving economic status. This study contributes to previous literature on how immigrants' different social capital is related to their psychological well-being.


Asunto(s)
Emigrantes e Inmigrantes , Capital Social , China , Humanos , Japón , Apego a Objetos , Apoyo Social
15.
J Affect Disord Rep ; 3: 100066, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35434689

RESUMEN

Background: To investigate youth mental health changes over the course of coronavirus disease 2019 (COVID-19) using a national probability sample and longitudinal design. Methods: A representative sample of 4918 Chinese college students were surveyed during the initial outbreak of the COVID-19 pandemic for the first wave and after the new cases steadily declined for the second wave. Mental health was measured by the ten-question Kessler Psychological Distress Scale (K-10). Logistic regression model was fitted to compare changes in psychological distress before and after the peak of the pandemic. Results: Of the respondents of both waves, 45.04% reported psychological distress during the initial outbreak of the pandemic and 26.49% reported it when new COVID-19 cases steadily declined. Psychological distress significantly reduced after the peak of the pandemic but persisted in some students. Limitations: The study measured psychological distress once after the initial control of the COVID-19. More psychiatric disorders need to be traced as the pandemic continues to evolve. Conclusions: Although effective control of COVID-19 benefited young people's mental health, psychiatric disorders continued to be prevalent. Future research public health policies should target the speedy recovery of the high-risk cases with persistent mental health problems.

16.
Nat Commun ; 11(1): 5478, 2020 Oct 30.
Artículo en Inglés | MEDLINE | ID: mdl-33127912

RESUMEN

Elucidating the structure-property relationship is crucial for the design of advanced electrocatalysts towards the production of hydrogen peroxide (H2O2). In this work, we theoretically and experimentally discovered that atomically dispersed Lewis acid sites (octahedral M-O species, M = aluminum (Al), gallium (Ga)) regulate the electronic structure of adjacent carbon catalyst sites. Density functional theory calculation predicts that the octahedral M-O with strong Lewis acidity regulates the electronic distribution of the adjacent carbon site and thus optimizes the adsorption and desorption strength of reaction intermediate (*OOH). Experimentally, the optimal catalyst (oxygen-rich carbon with atomically dispersed Al, denoted as O-C(Al)) with the strongest Lewis acidity exhibited excellent onset potential (0.822 and 0.526 V versus reversible hydrogen electrode at 0.1 mA cm-2 H2O2 current in alkaline and neutral media, respectively) and high H2O2 selectivity over a wide voltage range. This study provides a highly efficient and low-cost electrocatalyst for electrochemical H2O2 production.

17.
NPJ Parkinsons Dis ; 6: 27, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33083521

RESUMEN

To compare the differences between asleep and awake robot-assisted deep brain stimulation (DBS) surgery for Parkinson's Disease (PD), we conducted this retrospective cohort study included 153 PD patients undergoing bilateral robot-assisted DBS from June 2017 to August 2019, of which 58 cases were performed under general anesthesia (GA) and 95 cases under local anesthesia (LA). Procedure duration, stimulation parameters, electrode implantation accuracy, intracranial air, intraoperative electrophysiological signal length, complications, and Unified PD Rating Scale (UPDRS) measurements were recorded and compared. The clinical evaluation was conducted by two raters who were blinded to the choice of anesthesia. Procedure duration was significantly shorter in the GA group, while on stimulation off medication motor scores (UPDRS-III) were significantly improved in both the GA and LA group. ANCOVA covariated for the baseline UPDRS-III and levodopa challenge exhibited no significant differences. In terms of amplitude, frequency, and pulse width, the stimulation parameters used for DBS power-on were similar. There were no significant differences in electrode implantation accuracy, intraoperative electrophysiological signal length, or intracerebral hemorrhage (no occurrences in either group). The pneumocephalus volume was significantly smaller in the GA group. Six patients exhibited transient throat discomfort associated with tracheal intubation in the GA group. The occurrence of surgical incision infection was similar in both groups. Compared with the awake group, the asleep group exhibited a shorter procedure duration with a similar electrode implantation accuracy and short-term motor improvement. Robot-assisted asleep DBS surgery is a promising surgical method for PD.

18.
Int J Clin Oncol ; 25(10): 1879, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32833103

RESUMEN

The authors would like to update the affiliations and email addresses of the original publication as given in this correction.

19.
Int J Clin Oncol ; 25(7): 1215-1222, 2020 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32347433

RESUMEN

Glioblastoma (GBM) is one of the most malignant neural tumors, and patients with GBM often die soon after the onset. The pathogenesis of GBM is very complicated, and there is no effective treatment for GBM. The current research results show that a variety of microRNA (miRNA) are involved in the regulation of GBM occurrence and development through specific signal pathways. Meanwhile, as a non-invasive biological indicator, there is an important clinical value of miRNA in the diagnosis and prognosis of GBM. The research of targeted miRNA treatment for GBM is still in the cell and animal model stage, although the basic research shows a good result, there is still a certain distance to the clinical application.


Asunto(s)
Biomarcadores de Tumor/genética , Glioblastoma/genética , MicroARNs/genética , Animales , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/patología , Regulación Neoplásica de la Expresión Génica , Glioblastoma/mortalidad , Glioblastoma/patología , Glioblastoma/terapia , Humanos , Masculino , Pronóstico
20.
World J Gastroenterol ; 26(10): 1088-1097, 2020 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-32205999

RESUMEN

BACKGROUND: Hepatopulmonary syndrome (HPS) is an arterial oxygenation defect induced by intrapulmonary vascular dilatation (IPVD) in the setting of liver disease and/or portal hypertension. This syndrome occurs most often in cirrhotic patients (4%-32%) and has been shown to be detrimental to functional status, quality of life, and survival. The diagnosis of HPS in the setting of liver disease and/or portal hypertension requires the demonstration of IPVD (i.e., diffuse or localized abnormally dilated pulmonary capillaries and pulmonary and pleural arteriovenous communications) and arterial oxygenation defects, preferably by contrast-enhanced echocardiography and measurement of the alveolar-arterial oxygen gradient, respectively. AIM: To compare brain and whole-body uptake of technetium for diagnosing HPS. METHODS: Sixty-nine patients with chronic liver disease and/or portal hypertension were prospectively included. Brain uptake and whole-body uptake were calculated using the geometric mean of technetium counts in the brain and lungs and in the entire body and lungs, respectively. RESULTS: Thirty-two (46%) patients had IPVD as detected by contrast-enhanced echocardiography. The demographics and clinical characteristics of the patients with and without IPVD were not significantly different with the exception of the creatinine level (0.71 ± 0.18 mg/dL vs 0.83 ± 0.23 mg/dL; P = 0.041), alveolar-arterial oxygen gradient (23.2 ± 13.3 mmHg vs 16.4 ± 14.1 mmHg; P = 0.043), and arterial partial pressure of oxygen (81.0 ± 12.1 mmHg vs 90.1 ± 12.8 mmHg; P = 0.004). Whole-body uptake was significantly higher in patients with IPVD than in patients without IPVD (48.0% ± 6.1% vs 40.1% ± 8.1%; P = 0.001). The area under the curve of whole-body uptake for detecting IPVD was significantly higher than that of brain uptake (0.75 vs 0.54; P = 0.025). The optimal cut-off values of brain uptake and whole-body uptake for detecting IPVD were 5.7% and 42.5%, respectively, based on Youden's index. The sensitivity, specificity, and accuracy of brain uptake > 5.7% and whole-body uptake > 42.5% for detecting IPVD were 23%, 89%, and 59% and 100%, 52%, and 74%, respectively. CONCLUSION: Whole-body uptake is superior to brain uptake for diagnosing HPS.


Asunto(s)
Síndrome Hepatopulmonar/diagnóstico , Imagen de Perfusión/métodos , Cintigrafía/métodos , Radiofármacos/farmacocinética , Agregado de Albúmina Marcado con Tecnecio Tc 99m/farmacocinética , Adulto , Análisis de los Gases de la Sangre , Encéfalo/irrigación sanguínea , Encéfalo/metabolismo , Dilatación Patológica/diagnóstico , Femenino , Síndrome Hepatopulmonar/etiología , Humanos , Hipertensión Pulmonar/complicaciones , Hepatopatías/complicaciones , Pulmón/irrigación sanguínea , Pulmón/metabolismo , Masculino , Persona de Mediana Edad , Oxígeno/sangre , Estudios Prospectivos , Enfermedades Vasculares/diagnóstico , Enfermedades Vasculares/etiología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA