Bullous pemphigoid (BP) is an acquired autoimmune blistering disorder of unknown etiology uncommon in childhood. Unlike adult BP, infantile BP shows acral distribution and resolves rapidly with systemic steroids. We report three infants with infantile BP presenting shortly after vaccination for diphtheria, pertussis, tetanus, poliomyelitis, hepatitis B, Haemophilus influenzae B, and meningococcus C. Our cases further reinforce the causal association between childhood BP and vaccination.
Diphtheria-Tetanus-Pertussis Vaccine/adverse effects , Hepatitis B Vaccines/adverse effects , Pemphigoid, Bullous/etiology , Pemphigoid, Bullous/pathology , Poliovirus Vaccine, Oral/adverse effects , Female , Haemophilus Vaccines/adverse effects , Humans , Infant , Male , Meningococcal Vaccines/adverse effects
Actinic lichen planus (ALP) is a photosensitive variant of lichen planus, affecting mainly young adults of Middle Eastern descent. We report a case of ALP in a 9-year-old Colombian girl with an excellent response to hydroxychloroquine and photoprotection.
Antimalarials/therapeutic use , Facial Dermatoses/drug therapy , Hydroxychloroquine/therapeutic use , Lichen Planus/drug therapy , Photosensitivity Disorders/drug therapy , Child , Facial Dermatoses/pathology , Female , Humans , Lichen Planus/pathology , Photosensitivity Disorders/pathology , Treatment Outcome
We report an exceptional case of umbilical basal cell carcinoma (BCC) in a 21-year-old man, whose correct diagnosis was suggested by dermoscopy during initial complete body mole mapping. Although BCC is a common skin tumor, only 7 cases of BCC arising within the umbilicus have been reported previously. To the best of our knowledge, our patient is unique because of his age, being the youngest case of umbilical BCC described in the literature. Complete examination and digital dermoscopic monitoring let us identify an asymptomatic, nonpigmented papule at the umbilicus. Dermoscopy images revealed signs of superficial ulceration and several types of vascular structures, which gave us the clue for the diagnosis and helped us differentiate it from other lesions such as Spitz nevus or amelanotic melanoma. The diagnosis was confirmed with histopathology after excision and there was no evidence of relapse in the following four years.
Carcinoma, Basal Cell/pathology , Skin Neoplasms/pathology , Carcinoma, Basal Cell/diagnosis , Dermoscopy , Humans , Male , Neoplasms, Multiple Primary , Nevus, Pigmented/pathology , Skin Neoplasms/diagnosis , Umbilicus , Young Adult
Laugier-Hunziker syndrome (LHS) is an acquired, benign, macular hyperpigmentation of the lips and oral mucosa, often associated with pigmentation of the nails. Volar acral maculae on the palms and fingertips of patients affected by LHS are a typical feature of this rare entity. Dermoscopic examination of these maculae has been described in a previous report, in which authors found a parallel-furrow pattern. We describe two cases in which a parallel-ridge pattern (PRP) was found on the dermoscopic examination of the pigmented acral lesions. Histological examination showed increased melanin in basal keratinocytes, which was most prominent in those located at the crista intermedia profunda, that is, in the epidermal rete ridges underlying the surface ridges. In our study, dermoscopic features of the pigmented maculae found on LHS differed from those previously described. In addition, by means of this case report, the histological features of these lesions are described for the first time, showing an excellent correlation with dermoscopy. The reported cases prove that although the PRP is very specific of melanoma, it is also possible to find it in benign lesions. Therefore, we must be familiar with the differential diagnosis of PRP, and take into consideration the clinical context in which we find it. Further studies are needed to increase our knowledge on the histological and dermoscopic features of acral pigmented maculae of LHS.
Dermoscopy , Hand Dermatoses/pathology , Hyperpigmentation/pathology , Aged , Diagnosis, Differential , Female , Fingers , Humans , Lip Diseases/pathology , Middle Aged , Mouth Mucosa/pathology , Nails/pathology , Syndrome
Congenital syphilis (CS) is a preventable disease. Nevertheless, since the year 2000, there has been an upward trend in incidence in Spain, similar to what has occurred in other European countries. We present a case of early congenital syphilis showing the classical features of the disease, in which skin lesions gave the clue that led to the diagnosis.
Syphilis, Congenital/diagnosis , Syphilis, Cutaneous/diagnosis , Treponema pallidum/isolation & purification , Fever/drug therapy , Fever/microbiology , Humans , Incidence , Infant, Newborn , Male , Penicillins/therapeutic use , Periostitis/diagnostic imaging , Periostitis/drug therapy , Prevalence , Radiography , Spain/epidemiology , Syphilis, Congenital/drug therapy , Syphilis, Congenital/epidemiology , Syphilis, Cutaneous/drug therapy , Syphilis, Cutaneous/epidemiology
BACKGROUND: Gorlin-Goltz syndrome (GGS) is an autosomal-dominant disease characterized by the early onset of multiple basal cell carcinomas (BCCs), among other findings. Clinically, the BCCs may appear as soft pedunculated neoplasms that can be mistaken for true acrochordons. OBJECTIVE: We sought to describe the dermatoscopic characteristics of small acrochordon-like or polypoid BCCs in a child with GGS, and to perform histopathologic correlation. METHODS: Acrochordon-like growths from a child with GGS were studied. Clinical records and digital dermatoscopic images were collected, and excision and histopathologic examination of the most representative lesions were performed. RESULTS: Some acrochordon-like lesions showed specific dermatoscopic criteria for BCC, including multiple blue-gray globules and arborizing telangiectasia. Other polypoid lesions, especially the smaller ones, exhibited characteristics that suggested BCC, such as isolated blue-gray globules, small blue-gray ovoid nests, and fine elongated telangiectases. LIMITATIONS: Conclusions are limited by the small sample size. CONCLUSION: Dermatoscopy may be a useful diagnostic tool to analyze acrochordon-like lesions in children and to facilitate early diagnosis and treatment of BCCs in patients with GGS.
Basal Cell Nevus Syndrome/pathology , Carcinoma, Basal Cell/pathology , Skin Neoplasms/pathology , Basal Cell Nevus Syndrome/diagnosis , Child , Dermoscopy , Humans , Male
El tratamiento de las metástasis cutáneas de melanoma puede ser difícil en muchos casos debido a la edad de los pacientes, así como al número, tamaño y localización de las lesiones. Se presenta el caso de un varón de 82 años con metástasis cutáneas de melanoma en el cuero cabelludo que respondieron satisfactoriamente al tratamiento con imiquimod al 5% en crema. El imiquimod es un inmunomodulador de uso tópico con actividad antiviral y antineoplásica. El presente caso, junto con otros recientemente publicados, apoya la utilidad de este tratamiento en casos seleccionados de metástasis cutáneas de melanoma, al menos con un fin paliativo
The treatment of skin metastases of melanoma can be difficult in many cases because of the patients age, as well as the number, size and location of the lesions. We present the case of an 82-year-old male with melanoma skin metastases on the scalp, which responded satisfactorily to treatment with 5% imiquimod cream. Imiquimod is a topical immunomodulator with antiviral and antineoplastic action. This case, along with others that have recently been published, supports the usefulness of this treatment in selected cases of melanoma skin metastases, at least for palliative purposes
Male , Aged , Humans , Melanoma/diagnosis , Melanoma/therapy , Antineoplastic Agents/therapeutic use , Skin Neoplasms/diagnosis , Skin Neoplasms/therapy , Scalp/pathology , Melanoma/radiotherapy , Neoplasm Metastasis/pathology , Neoplasm Metastasis/radiotherapy , Neoplasm Metastasis/therapy
In recent years, the demand for cosmetic interventions to augment soft tissue by injecting different substances has increased, due to their apparent innocuity. However, these procedures are not free from adverse reactions, such as the formation of foreign body granulomas, a phenomenon described in literature with most of the materials used. We report the case of a female patient with inflammatory lesions of the face, whose diagnosis was made after the histopathological study, which revealed a granuloma caused by liquid silicone.
Cosmetic Techniques/adverse effects , Granuloma, Foreign-Body/chemically induced , Silicones/adverse effects , Female , Humans , Middle Aged
The treatment of skin metastases of melanoma can be difficult in many cases because of the patients age, as well as the number, size and location of the lesions. We present the case of an 82-year-old male with melanoma skin metastases on the scalp, which responded satisfactorily to treatment with 5 % imiquimod cream. Imiquimod is a topical immunomodulator with antiviral and antineoplastic action. This case, along with others that have recently been published, supports the usefulness of this treatment in selected cases of melanoma skin metastases, at least for palliative purposes.
Aminoquinolines/administration & dosage , Antineoplastic Agents/administration & dosage , Head and Neck Neoplasms/drug therapy , Head and Neck Neoplasms/secondary , Melanoma/drug therapy , Melanoma/secondary , Scalp , Skin Neoplasms/drug therapy , Skin Neoplasms/secondary , Administration, Topical , Aged , Aged, 80 and over , Humans , Imiquimod , Male
El carcinoma sebáceo es un tumor cutáneo maligno poco frecuente. Aparece en el 75% de los casos en localización oculopalpebral, rica en varios tipos de glándulas sebáceas. La cabeza y cuello son las regiones extraoculares donde se han descrito con mayor frecuencia. Su curso clínico es agresivo y son habituales las recurrencias locales y las metástasis a distancia. Se presenta un caso de una mujer de 79 años que fue diagnosticada de un carcinoma sebáceo extraocular en mejilla derecha, varias hiperplasias sebáceas y un carcinoma intraepidérmico con diferenciación sebácea. Tras realizar una completa evaluación de historia familiar y personal de la paciente se descartó la asociación con el síndrome de Muir-Torre (AU)
Aged , Female , Humans , Adenocarcinoma, Sebaceous/pathology , Sebaceous Gland Neoplasms/pathology , Sebaceous Gland Neoplasms/surgery
La enfermedad de Fox-Fordyce es un trastorno inflamatorio poco frecuente caracterizado por la aparición de pápulas pruriginosas con distribución folicular localizadas en las áreas dotadas de glándulas apocrinas. La etiopatogenia no se conoce con claridad, involucrándose la obstrucción del conducto excretor apocrino como fenómeno precoz en el proceso. Se presenta un caso de enfermedad de Fox-Fordyce, confirmado histológicamente, en una mujer de 16 años, con gran expresividad clínica (AU)
Adolescent , Female , Humans , Adrenal Cortex Hormones/therapeutic use , Fox-Fordyce Disease/pathology , Fox-Fordyce Disease/drug therapy
