Las ampollas secundarias al tratamiento con PUVA son un efecto secundario de la fotoquimioterapia poco descrito en la literatura científica. Se caracteriza por la aparición espontánea de ampollas asintomáticas localizadas fundamentalmente en los miembros inferiores, que se resuelven sin necesidad de tratamiento. El diagnóstico diferencial debe plantearse con una reacción fototóxica, con la pseudoporfiria y con el penfigoide ampolloso inducido por PUVA. Presentamos 5 casos de ampollas secundarias a la terapia PUVA, con el objetivo de dar a conocer las características clínicas e histológicas de dicha entidad. Su correcto diagnóstico evitará la interrupción del tratamiento, así como la realización de procedimientos diagnósticos y terapéuticos innecesarios
Blíster associated with PUVA treatments are an adverse effect of photochemotherapy that has been reported in the literature. Asymptomatic blisters appear spontaneously mainly on the lower limbs and resolve without treatment. The differential diagnoses to consider include a phototoxic reaction, pseudoporphyria, and PUVA-induced bullous pemphigoid. We describe the clinical and histologic features in 5 cases of blistering secondary to PUVA treatment. If this adverse effect is accurately diagnosed, photochemotherapy need not be interrupted, and unnecessary diagnostic procedures and additional treatments can be avoided
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , PUVA Therapy/adverse effects , Skin Diseases, Vesiculobullous/chemically induced , Blister/etiology , Photochemotherapy/adverse effects , Anti-Infective Agents, Local/therapeutic use , Diagnosis, Differential , Dermatitis, Phototoxic/diagnosis , Fluorescent Antibody Technique, Direct/methods
No disponible
Humans , Female , Aged, 80 and over , Acrospiroma/diagnostic imaging , Ultrasonography/methods , Laryngeal Neoplasms/diagnostic imaging , Sweat Gland Neoplasms/diagnostic imaging , Skin/diagnostic imaging , Laryngeal Neoplasms/pathology , Immunohistochemistry , Diagnosis, Differential , Sweat Gland Neoplasms/pathology
Blisters associated with PUVA treatments are an adverse effect of photochemotherapy that has been reported in the literature. Asymptomatic blisters appear spontaneously mainly on the lower limbs and resolve without treatment. The differential diagnoses to consider include a phototoxic reaction, pseudoporphyria, and PUVA-induced bullous pemphigoid. We describe the clinical and histologic features in 5 cases of blistering secondary to PUVA treatment. If this adverse effect is accurately diagnosed, photochemotherapy need not be interrupted, and unnecessary diagnostic procedures and additional treatments can be avoided.
Blister/etiology , PUVA Therapy/adverse effects , Adult , Aged , Aged, 80 and over , Blister/diagnosis , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Mycosis Fungoides/drug therapy , Parapsoriasis/drug therapy , Pemphigoid, Bullous/diagnosis
Parvovirus B19 infection can cause a wide range of cutaneous manifestations, including papular-purpuric gloves-and-socks syndrome (PPGSS) and petechial bathing trunk eruption. We report a case of an immunocompetent woman with a primary parvovirus B19 infection presenting as concurrent PPGSS and petechial bathing trunk eruption. Parvovirus B19 seroconversion was confirmed several days after the onset of the clinical manifestations. The coexistence of these two cutaneous manifestations of primary parvovirus B19 infection has rarely been reported in the literature. It is important to recognize parvovirus B19 infection early, based on the cutaneous manifestations, to avoid potentially serious systemic complications in susceptible individuals.
DNA, Viral/analysis , Dermis/pathology , Erythema Infectiosum/diagnosis , Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Parvovirus B19, Human/genetics , Torso/pathology , Biopsy , Dermis/virology , Erythema Infectiosum/virology , Female , Foot Dermatoses/virology , Hand Dermatoses/virology , Humans , Middle Aged , Parvovirus B19, Human/isolation & purification , Polymerase Chain Reaction , Syndrome
Blister/chemically induced , Central Nervous System Depressants/poisoning , Coma/complications , Drug Overdose/complications , Blister/physiopathology , Clorazepate Dipotassium/poisoning , Coma/chemically induced , Duloxetine Hydrochloride/poisoning , Female , Fructose/analogs & derivatives , Fructose/poisoning , Humans , Ischemia/chemically induced , Personality Disorders/drug therapy , Pressure , Quetiapine Fumarate/poisoning , Skin/blood supply , Substance-Related Disorders/complications , Suicide, Attempted , Topiramate , Young Adult
Breast Neoplasms/radiotherapy , Neoplasms, Radiation-Induced/etiology , Radiotherapy, Adjuvant/adverse effects , Xanthomatosis/etiology , Aged, 80 and over , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Biopsy , Breast Neoplasms/drug therapy , Breast Neoplasms/surgery , Combined Modality Therapy , Diagnosis, Differential , Female , Humans , Mastectomy , Mastitis/diagnosis , Neoplasm Recurrence, Local/diagnosis
La dermatitis anular liquenoide de la infancia es una entidad de etiología desconocida que forma parte del grupo de las dermatosis liquenoides. Afecta sobre todo a niños y adolescentes, mostrando unas características clinicopatológicas definidas que permiten su diagnóstico. Presentamos 2 nuevos casos de dermatitis liquenoide anular de la infancia en 2 niñas de 4 y 2 años y medio, respectivamente, que presentan las características clínicas clásicas de esta entidad. A diferencia del resto de casos publicados el examen histopatológico mostró un infiltrado inflamatorio liquenoide situado principalmente en el techo de las papilas dérmicas, y no en la punta de las crestas epidérmicas. En ambos casos las lesiones regresaron espontáneamente sin necesidad de tratamiento
Annular lichenoid dermatitis of youth is a lichenoid dermatosis of unknown etiology. It mostly affects children and adolescents and has well-defined clinical and histological characteristics that permit a diagnosis. We present 2 new cases of annular lichenoid dermatitis of youth with classical clinical features in 2 girls, aged 2 and 4 years. The histologic findings, however, differed from those reported in the literature in that the lichenoid inflammatory infiltrate was located primarily at the top of the dermal papillae and not at the tips of the rete ridges. In both cases, the lesions regressed spontaneously without treatment
Humans , Female , Infant , Lichenoid Eruptions/diagnosis , Mycosis Fungoides/diagnosis , Biopsy , Diagnosis, Differential , Dermatomycoses/diagnosis
Annular lichenoid dermatitis of youth is a lichenoid dermatosis of unknown etiology. It mostly affects children and adolescents and has well-defined clinical and histological characteristics that permit a diagnosis. We present 2 new cases of annular lichenoid dermatitis of youth with classical clinical features in 2 girls, aged 2 and 4 years. The histologic findings, however, differed from those reported in the literature in that the lichenoid inflammatory infiltrate was located primarily at the top of the dermal papillae and not at the tips of the rete ridges. In both cases, the lesions regressed spontaneously without treatment.
Lichenoid Eruptions/pathology , Child, Preschool , Female , Humans
