RESUMEN
HLA-DRB1*04:379N differs from HLA-DRB1*04:01:01:01 by one nucleotide substitution in codon 4 in exon 1.
Asunto(s)
Alelos , Secuencia de Bases , Exones , Cadenas HLA-DRB1 , Prueba de Histocompatibilidad , Análisis de Secuencia de ADN , Humanos , Cadenas HLA-DRB1/genética , Prueba de Histocompatibilidad/métodos , Análisis de Secuencia de ADN/métodos , Codón , Alineación de SecuenciaRESUMEN
HLA-DQB1*02:01:01:21Q differs from HLA-DQB1*02:01:01:01 by one nucleotide substitution in the splice site in the beginning of intron 3.
Asunto(s)
Secuencia de Bases , Humanos , Alelos , Cadenas beta de HLA-DQ/genética , IntronesRESUMEN
HLA-DQA1*01:03:11 differs from HLA-DQA1*01:03:01:02 by one nucleotide substitution in codon 59 in exon 2.
Asunto(s)
Nucleótidos , Humanos , Alelos , Cadenas alfa de HLA-DQ/genética , Exones/genéticaRESUMEN
HLA-DPB1*1516:01 differs from HLA-DPB1*1229:01 by seven nucleotide substitutions in exon 3.
Asunto(s)
Secuencia de Bases , Humanos , Alelos , Cadenas beta de HLA-DP/genética , Exones/genéticaRESUMEN
HLA-DRB3*02:194 differs from HLA-DRB3*02:02:01:02 by one nucleotide substitution in codon 78 in exon 2.
Asunto(s)
Secuencia de Bases , Humanos , Cadenas HLA-DRB3/genética , Alelos , Prueba de Histocompatibilidad , Codón , Análisis de Secuencia de ADN , Cadenas HLA-DRB1RESUMEN
The selection of a donor is an essential element in allogeneic hematopoietic stem cell transplantation. In the absence of an HLA-matched related donor, the selection of an unrelated donor is considered, and is currently the most common type of allogenic donor used in practice. Many criteria are considered for the selection when multiple donors are available, particularly in case of partial match. The aim of this workshop is to assist in the selection of an unrelated donor, in keeping with recent data from the literature.
Asunto(s)
Trasplante de Médula Ósea , Trasplante de Células Madre Hematopoyéticas , Humanos , Donante no Emparentado , Selección de Donante , Sociedades MédicasRESUMEN
HLA-DRB1*11:324 differs from HLA-DRB1*11:62:02 by one nucleotide substitution in codon 38 in exon 2.
Asunto(s)
Cadenas HLA-DRB1 , Humanos , Cadenas HLA-DRB1/genética , Secuencia de Bases , Alelos , Exones/genética , CodónRESUMEN
HLA-DRB1*13:03:13 differs from HLA-DRB1*13:03:01:01 by one nucleotide substitution in codon 180 in exon 3.
Asunto(s)
Cadenas HLA-DRB1 , Humanos , Cadenas HLA-DRB1/genética , Secuencia de Bases , Alelos , Exones/genética , CodónRESUMEN
HLA-B*08:312 differs from HLA-B*08:01:01:01 by one nucleotide substitution in codon 324 in exon 6.
Asunto(s)
Antígenos HLA-B , Humanos , Alelos , Prueba de Histocompatibilidad , Codón , Análisis de Secuencia de ADNRESUMEN
T-cell mediated rejection (TCMR), de novo anti-HLA donor-specific antibodies (dnDSAs) and ensuing antibody-mediated rejection (ABMR) reduce kidney transplantation (KT) survival. The immunomodulatory effects of 25-hydroxyvitamin D [25(OH)D] could be beneficial for KT outcomes. We aimed to evaluating the association between 25(OH)D levels, the development of dnDSAs, clinical TCMR and ABMR, and graft survival. This single center retrospective study included 253 KT recipients (KTRs) transplanted without preformed DSA between 2010 and 2013. We measured 25(OH)D in successive serum samples: at KT (M0) and M12 for the entire cohort, and additionally at M24 and/or M36 when sera were available. We assessed graft outcomes up to 5 years post-KT. The proportion of KTRs having sufficient 25(OH)D at KT (M0) was high (81.4%) and then dropped at M12 (71.1%). KTRs with sufficient 25(OH)D at M0 experienced less clinical TCMR (HR, 0.41; 95% CI, 0.19-0.88 in multivariate analysis). A sufficient 25(OH)D at M12 was independently associated with a longer dnDSA-free survival (HR, 0.34; 95% CI, 0.17-0.69). There was no association between 25(OH)D and clinical AMBR. Studying the KTRs with 25(OH)D measurements at M12, M24 and M36 (n = 203), we showed that 25(OH)D sufficiency over the 3 first-years post-KT was associated with a longer graft survival in multivariate analyses (HR, 0.39; 95% CI, 0.22-0.70). To our knowledge, this study is the first showing an association between 25(OH)D sufficiency post-KT and dnDSA occurrence in KTRs. Moreover, we reinforce previously published data showing an association between 25(OH)D, TCMR and graft survival in KT.
Asunto(s)
Trasplante de Riñón , Vitamina D/análogos & derivados , Humanos , Estudios Retrospectivos , Factores de Riesgo , Antígenos HLA , Alelos , Anticuerpos , Rechazo de Injerto , IsoanticuerposRESUMEN
HLA-B*44:324:02 differs from HLA-B*44:324:01 by one nucleotide substitution in codon 99 in exon 3.
Asunto(s)
Antígenos HLA-B , Humanos , Alelos , Prueba de Histocompatibilidad , Codón , Análisis de Secuencia de ADNRESUMEN
HLA-DRB1*01:140 differs from HLA-DRB1*01:02:01:01 by one nucleotide substitution in codon 147 in exon 3.
Asunto(s)
Cadenas HLA-DRB1 , Humanos , Cadenas HLA-DRB1/genética , Secuencia de Bases , Alelos , Exones/genética , CodónRESUMEN
HLA-DQA1*02:01:14 differs from HLA-DQA1*02:01:01:02 by one nucleotide substitution in codon 105 in exon 3.
Asunto(s)
Alelos , Humanos , Cadenas alfa de HLA-DQ/genética , Análisis de Secuencia de ADN , CodónRESUMEN
HLA-DPA1*02:01:21 differs from HLA-DPA1*02:01:01:03 by one nucleotide substitution in codon 190 in exon 4.
Asunto(s)
Cadenas alfa de HLA-DP , Humanos , Alelos , Alineación de Secuencia , Prueba de Histocompatibilidad , Cadenas alfa de HLA-DP/genética , Análisis de Secuencia de ADNRESUMEN
HLA-B*15:01:01:65Q differs from HLA-B*15:01:01:01 by one nucleotide substitution in the splice site in the beginning of intron 3.
Asunto(s)
Antígenos HLA-B , Humanos , Secuencia de Bases , Alelos , Prueba de Histocompatibilidad , Exones/genética , Análisis de Secuencia de ADNRESUMEN
HLA-DQA1*01:89 differs from HLA-DQA1*01:01:01:01 by one nucleotide substitution in codon -5 in exon 1.
Asunto(s)
Alelos , Humanos , Cadenas alfa de HLA-DQ/genética , Análisis de Secuencia de ADN , Exones/genéticaRESUMEN
HLA-C*07:1023 differs from HLA-C*07:01:01:01 by one nucleotide substitution in codon 313 in exon 5.
Asunto(s)
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Prueba de Histocompatibilidad , Análisis de Secuencia de ADN , Exones/genéticaRESUMEN
HLA-C*03:606 differs from HLA-C*03:03:01:01 by one nucleotide substitution in codon 276 in exon 5.
Asunto(s)
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Prueba de Histocompatibilidad , Análisis de Secuencia de ADN , Exones/genéticaRESUMEN
HLA-C*12:354 differs from HLA-C*12:03:01:01 by one nucleotide substitution in codon 240 in exon 4.
Asunto(s)
Antígenos HLA-C , Alelos , Exones/genética , Antígenos HLA-C/genética , Prueba de Histocompatibilidad , Humanos , Análisis de Secuencia de ADNRESUMEN
HLA-DQB1*02:197 differs from HLA-DQB1*02:01:01:01 by one nucleotide substitution in codon 18 in exon 2.