Asunto(s)
Fármacos Cardiovasculares , Medicamentos Herbarios Chinos , Infarto del Miocardio , Fitoterapia , Extractos Vegetales , Humanos , Fármacos Cardiovasculares/uso terapéutico , Mezclas Complejas , Medicamentos Herbarios Chinos/uso terapéutico , Medicina Tradicional China , Infarto del Miocardio/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Polvos , Resultado del TratamientoAsunto(s)
Bloqueadores de los Canales de Calcio , Insuficiencia Cardíaca , Humanos , Bloqueadores de los Canales de Calcio/uso terapéutico , Ensayos Clínicos Controlados Aleatorios como Asunto , Antagonistas Adrenérgicos beta/efectos adversos , Volumen Sistólico , Insuficiencia Cardíaca/tratamiento farmacológico , HospitalizaciónRESUMEN
(1) Background: Chronic inflammation and fibrosis are key players in cardiac remodeling associated with left ventricular hypertrophy (LVH) and heart failure with a preserved ejection fraction (HFpEF). Monocytes and T-helpers (Th) are involved in both pro-inflammatory and fibrotic processes, while regulatory T-cells (Treg) could be considered to suppress chronic inflammation in the hypertrophied myocardium. We aimed to estimate the relationship between the frequencies of circulating CD4+ T-cell and monocyte subpopulations and the variables of left ventricular (LV) diastolic function in patients with LVH depending on the presence of HFpEF. (2) Methods: We enrolled 57 patients with asymptomatic hypertensive LVH (n = 21), or LVH associated with HFpEF (n = 36). A clinical assessment and echocardiographs were analyzed. CD4+ Treg, activated Th (Th-act), and monocyte (classical, intermediate, and non-classical) subpopulations were evaluated via direct immunofluorescence and flow cytometry. (3) Results: Patients with HFpEF had a lower Treg/Th-act ratio (p = 0.001). Though asymptomatic patients and patients with HFpEF were comparable in terms of both the total monocyte number and monocyte subsets, there were moderate correlations between intermediate monocyte count and conventional and novel echocardiographic variables of LV diastolic dysfunction in patients with HFpEF. (4) Conclusions: In patients with LVH, the clinical deterioration (transition to HFpEF) and progression of LV diastolic dysfunction are probably associated with T-cell disbalance and an increase in intermediate monocyte counts.
RESUMEN
Left atrial (LA) dysfunction seems to play a central role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), is associated with disease severity and poor outcomes and potentially impacts management. Identifying LA myopathy can help guide tailored therapy for HFpEF. Echocardiography allows the accurate measurement of atrial size and function, where LA strain appears to be a sensitive measure of intrinsic LA myopathy. Several therapies and devices that decompress of left atrium are being tested for HFpEF. Further investigation is required to understand the specific atrial effects of statins, mineralocorticoid receptor antagonists, and other therapies.