Synthesis and Cytotoxic Evaluation of Artemisinin-triazole Hybrids.

Dihydroartemisinin was converted to its corresponding alkyne-functionalized esters, which were subsequently deployed as substrates for a 'click' chemistry-mediated coupling-with 3'-azido-3'-deoxythydimine (AZT) to furnish novel triazole-artesunate-AZT hybrid compounds. Moreover, various substituted triazole-artemisinin :hybrids were synthesized based on 'click' chemistry between propargyl-substituted derivatives and artemisinin containing a 2-hydroxypropane unit. Fourteen new hybrids were thus successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole-artemisinin derivative hybrids in KB and HepG2 cancer cell lines.

Comparison of Treated Mean Intraocular Pressure in Stable Glaucoma with Different Severity in Vietnam.

PURPOSE: To compare stable glaucoma with different severity in a Vietnamese population in regard to mean intraocular pressure (IOP) and number of medications used. MATERIALS AND METHODS: A total of 116 eyes from 68 patients with medically treated glaucoma were prospectively enrolled at a single center and subjected to automated perimetry every 3 months for at least 9 months. Glaucoma progression was identifed according to early manifest glaucoma trial criterion using glaucoma progression analysis software. Eyes in which no progression was identifed were staged for glaucoma severity using field criteria (mild MD ≥ 6 dB, moderate MD -6 to -12 dB, advanced MD ≥ 12 dB, end-stage central island only). Groups were compared in terms of mean IOP and number of medications used. Statistical analysis was performed using SPSS v16.0. RESULTS: A total of 109 eyes displayed no evidence of pro gres-sion during the study period. Pretreatment mean IOP for mild, moderate, severe and end-stage glaucoma was 28.2 ± 1.4, 28.8 ± 1.6, 29.1 ± 1.8, and 28.6 ± 0.8 mm Hg. The mean IOP of all 109 eyes during follow-up was 16.8 ± 1.4 mm Hg (95% conf dence interval = 15.4 ± 18.2 mm Hg). Mild, moderate, advan ced, and end-stage glaucoma had mean IOP of 17.5 ± 1.2, 16.9 ± 1.3, 15.8 ± 0.9 and 15.5 ± 1.1 mm Hg. The mean IOP of mild stage was significantly higher than advanced and end-stage (t-test, p < 0.001). Also, the mean IOP of moderate glaucoma was significantly higher than advanced and end-stage glaucoma (t-test, p < 0.05). Number of medications had no signi ficant difference among these glaucoma stages (chi-square test, p > 0.05). CONCLUSION: Reached IOP lowering contributes to glaucoma stabilization especially in late stages. To maintain stable glaucoma, there was no difference in medical procedure of glaucoma stages. How to cite this article: Thanh NTH. Comparison of Treated Mean Intraocular Pressure in Stable Glaucoma with Different Severity in Vietnam. J Current Glau Prac 2014;8(1):7-9.

Effect of dietary regimen on the nutritional status and acute respiratory tract infection in infant

Across-sectional study was carried out in infants, at 7 communes of Ninh Thanh district, H¶i H­ng province, from 1995-1996. The methods for data collection were Anthopometric measurements, dietary assessment by 24 hour food recall method, clinical examination, and interview of the mothers by close ended questionnaires. The results of the study as follows: (1) Poor nutritional status was accompanied by high prevalence of acute respiratory infections (ARI). Interview of the history of diseases showed that poorer nutritional status was higher prevalence of acute respiratory infection (ARI). (2) Mean of energy intake per child per day of the children who suffered from lower and upper ARI was significantly different from the health children. The energy intake was different among three groups which have different nutritional status, but no significantly. (3) Protein and lipid intake of the children suffered from lower and upper ARI were significant lower than the healthy children. (4) Children suffered from lower and upper ARI had vitamin A intake was significant lower than the healthy children. The mean of Vitamin A intake of children suffered from mild, moderate and normal was significant different from each other.

The effectiveness of nutrition education and communication for the mothers who have malnourished infant under twelve months

The survey on 404 infants under twelve months in the 4 rural communes in Ninh Thanh district, Hai Hung province showed that high prevalence of underweight (14.6%), acute respiratory infection (84.7%) among the subjects. The main reason is low education level of the mother, low birth weight, lack of breast milk, early giving supplementary food, poor quality of supplementary food. The nutrition education and communication had improved the nutritional knowledge of these mothers.

Food complementary for children during the growth period

The duration of starting the complement eating was an initial duration of growth of children. Many studies showed that children's slow development occurred within 6-18 months and following. The diet and other intervention impacted significantly on the intervention of children development during this period.

Efficacy of the food supplementation for children with poor nutritional status and acute respiratory tract infection

Milk supplementation in 3 months had improved the nutritional status of infant in term of physical growth, hemoglobin and serum albumin level, as well as acute respiratory infection status. The prevalence of underweight grade 1 reduced from 83.1% to 13.6%, underweight grade 2 reduced from 15.3% to 6.8% and there was no case of severe malnutrition. Hemoglobin level increased from 8.961.04 g/dl to 11.21.15 g/dl and serum albumin increased from 3.940.62g/dl to 4.790.42g/dl. The prevalence of acute respiratory infection reduced from 84.7- 27.1%.