The role of remote ischemic preconditioning in organ protection after cardiac surgery: a meta-analysis.

BACKGROUND: Remote ischemic preconditioning (RIPC) appears to protect distant organs from ischemia-reperfusion injury. We undertook meta-analysis of clinical studies to evaluate the effects of RIPC on organ protection and clinical outcomes in patients undergoing cardiac surgery. METHODS: A review of evidence for cardiac, renal, and pulmonary protection after RIPC was performed. We also did meta-regressions on RIPC variables, such as duration of ischemia, cuff pressure, and timing of application of preconditioning. Secondary outcomes included length of hospital and intensive care unit stay, duration of mechanical ventilation, and mortality at 30 days. RESULTS: Randomized control trials (n = 25) were included in the study for quantitative analysis of cardiac (n = 16), renal (n = 6), and pulmonary (n = 3) protection. RIPC provided statistically significant cardiac protection (standardized mean difference [SMD], -0.77; 95% confidence interval [CI], -1.15, -0.39; Z = 3.98; P < 0.0001) and on subgroup analysis, the protective effect remained consistent for all types of cardiac surgical procedures. However, there was no evidence of renal protection (SMD, 0.74; 95% CI, 0.53, 1.02; Z = 1.81; P = 0.07) or pulmonary protection (SMD, -0.03; 95% CI, -0.56, 0.50; Z = 0.12; P = 0.91). There was no statistical difference in the short-term clinical outcomes between the RIPC and control groups. CONCLUSIONS: RIPC provides cardiac protection, but there is no evidence of renal or pulmonary protection in patients undergoing cardiac surgery using cardiopulmonary bypass. Larger multicenter trials are required to define the role of RIPC in surgical practice.

Endovascular aortic repair: can we predict who will not get long-term benefit?

AIM: The aim of this study is to review our endovascular aortic repair (EVAR) experience in Dunedin Public Hospital as well as assessing the applicability of Mount Sinai score and the American Society of Anesthesiologists physical status classification (ASA) in finding which patients will be most likely to benefit from EVAR. METHODS: A retrospective study of 54 patients who had EVAR from 2000 to December 2009 in Dunedin Public Hospital was conducted. Univariate, bivariate and multivariate regressions analyses were used in assessing the data with the occurrence of postoperative complications and mortality as the primary outcome variable. RESULTS: The overall mortality at 30 days was 1.8%. The Mount Sinai score and smoking status were both found to be significant predictors of mortality. DISCUSSION: The Mount Sinai score was a good predictor for mortality as it factors in the patient's comorbidities. This study indicates that smoking status was an important factor and it should be added to long-term risk predicting models.

Non-traumatic spontaneous spinal subdural haematoma.

We are presenting a case of non-traumatic spontaneous spinal subdural hematoma in a patient on warfarin and fluoxetine. This diagnosis should be considered early in patients who are on warfarin or fluoxetine or both presenting with acute neurological abnormalities of the limbs, and early decompression could result in good neurological outcome.