1.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 881-5, 2005.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16248054
RESUMEN
A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5-position have been synthesised These compounds bear a 5'-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding alpha-linker nucleosides with L-xylose and L-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP.