RESUMEN
OBJECTIVES: Congenital afibrinogenemia is an autosomal recessive inherited disorder that can cause thrombotic as well as hemorrhagic events. We describe a case of repeated mild ischemic strokes due to a mural thrombus in the carotid artery and our medical treatment. CASE DESCRIPTION: A 49-year-old woman with congenital afibrinogenemia developed two minor ischemic strokes in two months. Clinical images revealed scattered fresh infarcts in the right middle cerebral artery region and mild cervical carotid artery stenosis. The risk for surgical treatment was considered to be extraordinarily high. The patient was treated with 100 mg/day of aspirin and 3 g fibrinogen infusion every two weeks. After the one-year course of medication, the mural thrombus gradually decreased, and there were no bleeding or ischemic stroke events. CONCLUSION: This case report highlights the successful treatment of an ischemic stroke in a patient with a congenital afibrinogenemia with an antiplatelet agent and fibrinogen replacement. There are no guidelines for managing ischemic stroke in patients with congenital afibrinogenemia, and further studies are needed.
Asunto(s)
Afibrinogenemia , Cardiopatías , Accidente Cerebrovascular Isquémico , Trombosis , Afibrinogenemia/complicaciones , Afibrinogenemia/diagnóstico , Afibrinogenemia/tratamiento farmacológico , Femenino , Fibrinógeno , Cardiopatías/tratamiento farmacológico , Hemorragia , Humanos , Accidente Cerebrovascular Isquémico/diagnóstico por imagen , Accidente Cerebrovascular Isquémico/tratamiento farmacológico , Persona de Mediana Edad , Trombosis/diagnóstico por imagen , Trombosis/tratamiento farmacológico , Trombosis/etiologíaRESUMEN
We report fast electro-optic response independent of cell thickness in cholesteric liquid crystals (ChLCs). Usually, an electric field normal to the helix axis of ChLCs induces two fast and one slow response components: helical elongation (slow one), helical deformation (fast one), and flexoelectric effect (fast one). In this study, we found that a planarly aligned ChLC applied with an in-plane electric field exhibited only fast response components because the glass substrates suppressed the motion of the helical elongation. Furthermore, we demonstrated complete separation of the remaining fast components by using dielectric measurement system. Consequently, we were able to analyze dynamics of the helical deformation in detail, in which response times exhibited quadratic dependence on the helical pitch and no dependence on the cell thickness.