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1.
Int. braz. j. urol ; 38(6): 842-854, Nov-Dec/2012. tab, graf
Artículo en Inglés | LILACS | ID: lil-666013

RESUMEN

Objective

To study the effect of ischemia preconditioning (IP) on renal ischemia/reperfusion (I/R)-associated functional injury and expression of renal adhesion molecules in rats. Materials and Methods

The ischemia preconditioning plan adopted in this experiment involved renal warm ischemia for 6 min. and blood flow for 4 min., repeated four times. The Wistar rat kidneys used for warm ischemia preconditioning were subjected to 60 min of renal warm ischemia followed by reperfusion. The rat kidneys with ischemia/reperfusion were compared with the ischemia preconditioning group to observe rat renal function and changes in the expression of renal adhesion molecules ICAM-1, P--Selectin, and E-Selectin. Results

The expression of rat renal adhesion molecules (ICAM-1, P-Selectin, and E-Selectin) with ischemia preconditioning was significantly lower than that of the ischemia/reperfusion group. Serum creatinine was significantly lower than that in the ischemia/reperfusion group after 48 hours. Conclusions

Ischemia preconditioning has a protective effect on renal function. Reduced expression of renal adhesion molecules is likely a mechanism involved in the observed protection. .


Asunto(s)
Animales , Femenino , Masculino , Ratas , Precondicionamiento Isquémico/métodos , Riñón/irrigación sanguínea , Daño por Reperfusión/prevención & control , Moléculas de Adhesión Celular/análisis , Creatinina/sangre , Modelos Animales de Enfermedad , Selectina E/análisis , Inmunohistoquímica , Riñón/patología , Selectina-P/análisis , Ratas Wistar , Daño por Reperfusión/patología , Factores de Tiempo
2.
Int Braz J Urol ; 38(6): 842-54, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23302405

RESUMEN

OBJECTIVE: To study the effect of ischemia preconditioning (IP) on renal ischemia/reperfusion (I/R)-associated functional injury and expression of renal adhesion molecules in rats. MATERIALS AND METHODS: The ischemia preconditioning plan adopted in this experiment involved renal warm ischemia for 6 min. and blood flow for 4 min., repeated four times. The Wistar rat kidneys used for warm ischemia preconditioning were subjected to 60 min of renal warm ischemia followed by reperfusion. The rat kidneys with ischemia/reperfusion were compared with the ischemia preconditioning group to observe rat renal function and changes in the expression of renal adhesion molecules ICAM-1, P-Selectin, and E-Selectin. RESULTS: The expression of rat renal adhesion molecules (ICAM-1, P-Selectin, and E-Selectin) with ischemia preconditioning was significantly lower than that of the ischemia/reperfusion group. Serum creatinine was significantly lower than that in the ischemia/reperfusion group after 48 hours. CONCLUSIONS: Ischemia preconditioning has a protective effect on renal function. Reduced expression of renal adhesion molecules is likely a mechanism involved in the observed protection.


Asunto(s)
Precondicionamiento Isquémico/métodos , Riñón/irrigación sanguínea , Daño por Reperfusión/prevención & control , Animales , Moléculas de Adhesión Celular/análisis , Creatinina/sangre , Modelos Animales de Enfermedad , Selectina E/análisis , Femenino , Inmunohistoquímica , Riñón/patología , Masculino , Selectina-P/análisis , Ratas , Ratas Wistar , Daño por Reperfusión/patología , Factores de Tiempo
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