Wideband polarization-independent plasmonic switch based on GST phase-change material.

Chalcogenide phase-change materials such as germanium-antimony-tellurium (GST) are suitable materials for use in tunable plasmonic devices. In this paper, a wideband plasmonic switch consists of gold cross-shaped resonators has been designed and simulated in the near-infrared region. The phase-change material GST makes the structure tunable, and by changing the temperature and switching between amorphous and crystalline states, the best extinction ratio of 14 dB and response time of 46 fs have been obtained at the wavelength of 1228 nm. The equivalent circuit model of the suggested structure has been extracted to verify the numerical results. Moreover, the effects of polarization and incident angles and geometric parameters on the structure performance have been evaluated. The proposed tunable and wideband switch with good switching capability can be used in various optical devices such as modulators, logic gates, and optical integrated circuits.

Formulation of Cinnarizine for Stabilization of Its Physiologically Generated Supersaturation.

Physiologically generated supersaturation and subsequent crystallization of a weakly basic drug in the small intestine leads to compromised bioavailability. In this study, the pH-induced crystallization of cinnarizine (CNZ) in the presence of different polymers was investigated. Inhibitory effect of Eudragit L100 (Eu) on crystallization of CNZ at varying supersaturation ratios was examined. The effect of Eu on the dissolution behavior of CNZ from CNZ/Eu physical mixtures (PMs) and solid dispersions (SDs) was assessed. Results showed that both Eu and hydroxypropyl methylcellulose (HPMC) have a considerable maintenance effect on supersaturation of CNZ but Eu was more effective than HPMC. When Eudragit was used the phenomenon of liquid-liquid phase separation (formation of colloidal phase) was observed at supersaturation ratio of 20 times above the solubility of the drug. PMs showed a higher area under the dissolution curve (AUDC) compared with plain CNZ. In contrast, SDs showed a lower AUDC than plain CNZ. For SDs, the AUDC was limited by the slow release of the drug from Eu in acidic pH which in turn hindered the creation of CNZ supersaturation following the transition of acidic to neutral pH. From these findings, it can be concluded that the ability of the formulation to generate supersaturation state and also maintain the supersaturation is vital for improving the dissolution of CNZ.