[Bulbar capillaroscopy and plethysmography for assessment of blood microcirculation and endothelium properties in type 1 diabetes]. / Bul'barnaia kapilliaroskopiia i pletizmografiia v otsenke mikrotsirkuliatsii krovi i svoistv éndoteliia pri sakharnom diabete 1-go tipa.

PURPOSE: To evaluate the properties of the microvasculature of bulbar conjunctiva and to assess the function of endothelium of the main arteries in type 1 diabetes mellitus (T1DM). MATERIAL AND METHODS: The study included 35 patients with T1DM and initial nonproliferative diabetic retinopathy (NPDR). The control group consisted of 30 subjects. In addition to standard ophthalmic examination, all participants underwent digital bulbar capillaroscopy (DBC), pulse wave velocity (PWV) test, and plethysmography for assessment of endothelium function. RESULTS: According to DBC, in comparison to the control group, diabetic patients with even initial NPDR had disturbances of blood microcirculation manifested as increased average venous vessel width (p=0.04), reduced arterial capillary blood flow (p=0.02), increased blood sludging (p=0.001), and increased duration of blood stasis (p=0.03). Evaluation of vessel endothelium in T1DM patients with NPDR showed increased PWV (p=0.03). CONCLUSION: Diabetic patients with NPDR showed marked changes of capillary blood flow alongside signs of endothelial dysfunction. The most significant change was increased venous vessel width.

[Assessment of microvascular bulbar conjunctiva in patients with type 1 diabetes]. / Otsenka sostoyaniya sosudov mikrotsirkulyatornogo rusla bul'barnoi kon''yunktivy u patsientov s sakharnym diabetom 1-go tipa.

UNLABELLED: The aim was to study the state of microvascular bulbar conjunctiva in patients with type 1 diabetes. MATERIAL AND METHODS: A clinical study of 25 patients with DR in the type 1 diabetes and 20 healthy persons without ophthalmopathology. All patients in addition to conventional methods of ophthalmological conducted computer Capillaroscopy bulbar conjunctiva. RESULTS: Results of the study showed patients with DR in the type 1 diabetes tortuosity of capillaries (due to thickening of the basement membrane), the expansion of the department of venous capillaries and arterial narrowing department, the formation of aggregates, the phenomenon of sludge and slowing blood flow. After a course of treatment (Tanakan 2 months to 120 mg. per day) capillaroscopy showed a positive trend state bulbar conjunctiva microvessels: reduction in the incidence of the phenomenon of sludge and the duration of stasis, increased blood flow, which correlated with the positive dynamics ophthalmoscopic picture. CONCLUSION: The results indicate the informativeness capillaroscopy as a method of assessing the state of the microvasculature in patients with type 1 diabetes.