Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study.

BACKGROUND: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD. STUDY DESIGN: A case-control study. METHODS: In this age-and sex-matched case-control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168-item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC. RESULTS: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91). CONCLUSION: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.

The relationship between dietary antioxidant intake and physical activity rate with nonalcoholic fatty liver disease (NAFLD): A case - Control study.

INTRODUCTION: Although dietary intakes, especially micronutrients, can be associated with the severity of nonalcoholic fatty liver disease (NAFLD), investigations on the amount of vitamins and antioxidants consumption and their relationship with NAFLD are very limited and incomplete. Therefore, we decided to investigate the relationship between antioxidant compounds intake and physical activity rate with NAFLD. METHODS: In this study, 200 patients with NAFLD for the case group and 400 healthy subjects for the control group were selected. Patients were diagnosed as NAFLD after giving blood tests and performing Ultrasonography by a radiology specialist. Dietary intakes were evaluated through a validated 168-items semi-quantitative food frequency questionnaire (FFQ). Physical activity rate was estimated by a validated short form of International Physical Activity Questionnaire (Short IPAQ). RESULTS: The study population was between 20 and 60 years old and 46% of them were women. Weight, waist circumference, hip circumference, WHR, and BMI in the cases were higher than the controls. Physical activity comparisons showed that controls had higher physical activity rate than cases. Mean consumption of vitamins C, A, D and alpha-tocopherol in case group was less than the other group. After adjustment for all potential confounder, subjects who were in highest tertile of vitamin A intake -in comparison to those in the lowest tertile of intake-decreased risk of NAFLD (OR = 0.40, 95%CI: 0.30-0.55). The same finding was obtained for vitamin D; [Top category vs. bottom category of vitamin D of intake (OR = 0.35, 95%CI: 0.20-0.61)]. CONCLUSIONS: We found that more intakes of vitamins A and D are related to lower risk of NAFLD in this group of Iranian adults. Physical activity rate in cases was less than the controls. Further prospective studies are required to confirm causal association between antioxidant compounds intake and NAFLD.