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AIM: To evaluate whether texture-based analysis of standard MRI sequences can help in the discrimination between benign and malignant head and neck tumors. MATERIALS AND METHODS: The MR images of 100 patients with a histologically clarified head or neck mass, from two different institutions, were analyzed. Texture-based analysis was performed using texture analysis software, with region of interest measurements for 2âD and 3âD evaluation independently for all axial sequences. COC, RUN, GRA, ARM, and WAV features were calculated for all ROIs. 10 texture feature subsets were used for a linear discriminant analysis, in combination with k-nearest-neighbor classification. Benign and malignant tumors were compared with regard to texture-based values. RESULTS: There were differences in the images from different field-strength scanners, as well as from different vendors. For the differentiation of benign and malignant tumors, we found differences on STIR and T2-weighted images for 2âD, and on contrast-enhanced T1-TSE with fat saturation for 3âD evaluation. In a separate analysis of the subgroups 1.5 and 3 Tesla, more discriminating features were found. CONCLUSION: Texture-based analysis is a useful tool in the discrimination of benign and malignant tumors when performed on one scanner with the same protocol. We cannot recommend this technique for the use of multicenter studies with clinical data. KEY POINTS: 2âD/3âD texture-based analysis can be performed in head and neck tumors. Texture-based analysis can differentiate between benign and malignant masses. Analyzed MR images should originate from one scanner with an identical protocol.
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Neoplasias de Cabeza y Cuello/diagnóstico por imagen , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Imagenología Tridimensional/métodos , Imagen por Resonancia Magnética/métodos , Adenocarcinoma/diagnóstico por imagen , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma Adenoide Quístico/diagnóstico por imagen , Carcinoma de Células Escamosas/diagnóstico por imagen , Niño , Diagnóstico Diferencial , Femenino , Humanos , Linfoma/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Sensibilidad y Especificidad , Programas Informáticos , Adulto JovenRESUMEN
BACKGROUND AND PURPOSE: The cause of syringomyelia in patients with Chiari I remains uncertain. Cervical spine anatomy modifies CSF velocities, flow patterns, and pressure gradients, which may affect the spinal cord. We tested the hypothesis that cervical spinal anatomy differs between Chiari I patients with and without syringomyelia. MATERIALS AND METHODS: We identified consecutive patients with Chiari I at 3 institutions and divided them into groups with and without syringomyelia. Five readers measured anteroposterior cervical spinal diameters, tonsillar herniation, and syrinx dimensions on cervical MR images. Taper ratios for C1-C7, C1-C4, and C4-C7 spinal segments were calculated by linear least squares fitting to the appropriate spinal canal diameters. Mean taper ratios and tonsillar herniation for groups were compared and tested for statistical significance with a Kruskal-Wallis test. Inter- and intrareader agreement and correlations in the data were measured. RESULTS: One hundred fifty patients were included, of which 49 had syringomyelia. C1-C7 taper ratios were smaller and C4-C7 taper ratios greater for patients with syringomyelia than for those without it. C1-C4 taper ratios did not differ significantly between groups. Patients with syringomyelia had, on average, greater tonsillar herniation than those without a syrinx. However, C4-C7 taper ratios were steeper, for all degrees of tonsil herniation, in patients with syringomyelia. Differences among readers did not exceed differences among patient groups. CONCLUSIONS: The tapering of the lower cervical spine may contribute to the development of syringomyelia in patients with Chiari I.
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Malformación de Arnold-Chiari/patología , Vértebras Cervicales/patología , Canal Medular/patología , Columna Vertebral/patología , Siringomielia/patología , Adulto , Envejecimiento , Malformación de Arnold-Chiari/diagnóstico por imagen , Vértebras Cervicales/diagnóstico por imagen , Encefalocele/diagnóstico por imagen , Encefalocele/patología , Femenino , Foramen Magno/diagnóstico por imagen , Foramen Magno/patología , Hernia/patología , Humanos , Imagen por Resonancia Magnética , Masculino , Variaciones Dependientes del Observador , Reproducibilidad de los Resultados , Caracteres Sexuales , Canal Medular/diagnóstico por imagen , Siringomielia/diagnóstico por imagenRESUMEN
In adult patients with acquired immunodeficiency syndrome (AIDS), cerebral arteritis usually takes the form of arterial wall thickening, stenosis, and occlusion, leading to cerebral ischemia and infarction. Aneurysms and intracranial hemorrhage are much less commonly associated with cerebral vasculitis. For reasons not entirely clear, this form is seen more often in pediatric patients infected with human immunodeficiency virus. We report an adult patient with cerebral aneurysmal arteriopathy who presented shortly after his AIDS-defining illness in a setting of severe immune suppression and high viral load.
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Arteritis del Sistema Nervioso Central por SIDA/patología , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Arteritis del Sistema Nervioso Central por SIDA/virología , Enfermedad Aguda , Adulto , Gadolinio , Humanos , Masculino , Índice de Severidad de la Enfermedad , Carga ViralRESUMEN
BACKGROUND AND PURPOSE: Single-shot, fast spin-echo, fluid attenuated inversion recovery (SS-FSE-FLAIR) images are frequently used to detect disease in the brain and subarachnoid space in confused or uncooperative patients who may move during the examination. In some of these patients, high signal intensity areas are seen on good-quality images in the subarachnoid space and ventricular system in locations not associated with high CSF flow. These artifacts may simulate hemorrhage or leptomeningeal disease. The purpose of this article was to determine the cause of these artifacts, describe ways to recognize them, and find methods to reduce or eliminate them. METHODS: Healthy volunteers were studied on 6 occasions with conventional multisection FSE-FLAIR images and SS-FSE-FLAIR images while at rest and while nodding and rotating their heads at different speeds. In addition, SS-FSE-FLAIR images with different section widths of the initial inverting pulse and a non-section-selective initial inversion pulse were performed with the subjects moving their heads in the same way. The scans of 30 successive patients with acute neurologic syndromes who had been studied with SS-FSE-FLAIR sequences were reviewed for evidence of high signal intensity in the CSF in regions not associated with high CSF flow. RESULTS: Each of the volunteers showed areas of increased signal intensity in CSF at sites apart from those associated with rapid pulsatile CSF flow on SS-FSE-FLAIR images acquired during head motion. The images were otherwise virtually free of motion artifact. The use of a wider initial inversion pulse section and a non-section-selected initial inversion pulse reduced the extent of these artifacts. Nineteen of the 30 patients showed areas of high signal intensity in the CSF in regions not associated with highly pulsatile CSF flow. Six of these patients had negative lumbar punctures for blood and xanthochromia and normal CSF protein levels. CONCLUSION: High signal intensity artifacts may be seen in CSF as a result of head movement on otherwise artifact-free images when imaging uncooperative patients with SS-FSE-FLAIR sequences. These artifacts have a different mechanism and distribution from those caused by CSF pulsation and may simulate subarachnoid and intraventricular hemorrhage. Artifact recognition is aided by signs of patient motion during the examination. The artifacts can be reduced by use of increased section width and non-section-selective initial inversion pulses. Recognition of these artifacts is important, because the circumstances in which the SS-FSE-FLAIR sequence is used and the particular properties of the sequence may conspire to produce a trap for the unwary.
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Artefactos , Hemorragia Cerebral/diagnóstico , Ventrículos Cerebrales , Imagen por Resonancia Magnética , Hemorragia Subaracnoidea/diagnóstico , Adulto , Diagnóstico Diferencial , Cabeza , Humanos , MovimientoRESUMEN
Normal volunteers, aged 30 to 99 years, were studied with MRI. Age was related to estimated volumes of: gray matter, white matter, and CSF of the cerebrum and cerebellum; gray matter, white matter, white matter abnormality, and CSF within each cerebral lobe; and gray matter of eight subcortical structures. The results were: 1) Age-related losses in the hippocampus were significantly accelerated relative to gray matter losses elsewhere in the brain. 2) Among the cerebral lobes, the frontal lobes were disproportionately affected by cortical volume loss and increased white matter abnormality. 3) Loss of cerebral and cerebellar white matter occurred later than, but was ultimately greater than, loss of gray matter. It is estimated that between the ages of 30 and 90 volume loss averages 14% in the cerebral cortex, 35% in the hippocampus, and 26% in the cerebral white matter. Separate analyses were conducted in which genetic risk associated with the Apolipoprotein E epsilon4 allele was either overrepresented or underrepresented among elderly participants. Accelerated loss of hippocampal volume was observed with both analyses and thus does not appear to be due to the presence of at-risk subjects. MR signal alterations in the tissues of older individuals pose challenges to the validity of current methods of tissue segmentation, and should be considered in the interpretation of the results.
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Envejecimiento/patología , Cerebelo/patología , Lóbulo Frontal/patología , Imagen por Resonancia Magnética/normas , Adulto , Anciano , Anciano de 80 o más Años , Apolipoproteína E4 , Apolipoproteínas E/genética , Femenino , Hipocampo/patología , Humanos , Masculino , Persona de Mediana Edad , Fibras Nerviosas/patología , Valores de ReferenciaRESUMEN
Viral infections of the brain and spinal cord cause significant morbidity and mortality in patients afflicted with AIDS. Debate continues over the specific mechanisms and pathways of how HIV-1 manifests itself in the brain and spinal cord. Attempts to predict which seropositive patients develop neurocognitive deficits caused by HIV-1 and how soon these deficits will occur in the course of disease have had limited success. The neuropathologic changes of HIV-1 must be distinguished from other viral infections, such as cytomegalovirus, JC papovavirus (progressive multifocal leukoencephalopathy), herpes simplex virus type 1, and varicella-zoster virus. In addition to cerebral spinal fluid sampling and serum testing, some specific features are seen with contrast-enhanced CT, MR imaging, proton MR spectroscopy, SPECT, and PET.
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Infecciones Oportunistas Relacionadas con el SIDA/diagnóstico , Enfermedades del Sistema Nervioso Central/diagnóstico , VIH-1 , Virosis/diagnóstico , Complejo SIDA Demencia/diagnóstico , Encefalopatías/diagnóstico , Sistema Nervioso Central/diagnóstico por imagen , Sistema Nervioso Central/patología , Infecciones por Citomegalovirus/diagnóstico , Humanos , Leucoencefalopatía Multifocal Progresiva/diagnóstico , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos XRESUMEN
RATIONALE AND OBJECTIVES: We studied the effect of fat suppression on signal intensity and contrast on contrast-enhanced magnetic resonance (MR) images of the spine. METHODS: Contrast-enhanced T1-weighted MR images were obtained at identical levels with and without fat suppression. Signal intensity and contrast were measured in regions of interest in fat, muscle, spinal bone marrow, and enhancing lesions. The differences in the mean values of these signal intensities and the mean values of contrast between enhanced tissues and bone marrow, fat, and muscle were subjected to statistical validation. RESULTS: Mean signal intensity of the extraspinal fat and bone marrow was lower after fat suppression (70% and 46% reduction, p < .001 and p < .05, respectively), whereas the signal intensity of muscle showed no significant change (p < .9). Enhancing spinal lesions showed a difference in mean signal intensity after fat suppression (22% increase, p < .2). Contrast between enhanced lesions and bone marrow and fat was higher after fat suppression (78% increase, p < .01 for bone marrow; 8% increase, p < .001 for fat). CONCLUSION: In contrast-enhanced MR examinations of the spine, the use of fat suppression may increase the signal intensity of the enhancing lesion by expanding the dynamic gray scale of the image and increases the contrast between the lesion and adjacent bone marrow and suppressed fat.
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Medios de Contraste , Aumento de la Imagen/métodos , Imagen por Resonancia Magnética/métodos , Enfermedades de la Columna Vertebral/diagnóstico , Columna Vertebral/patología , Tejido Adiposo/anatomía & histología , Adolescente , Adulto , Anciano , Médula Ósea/anatomía & histología , Niño , Cicatriz/diagnóstico , Cicatriz/patología , Femenino , Humanos , Desplazamiento del Disco Intervertebral/diagnóstico , Desplazamiento del Disco Intervertebral/patología , Imagen por Resonancia Magnética/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Músculo Esquelético/anatomía & histología , Complicaciones Posoperatorias , Reproducibilidad de los Resultados , Enfermedades de la Columna Vertebral/patología , Neoplasias de la Columna Vertebral/diagnóstico , Neoplasias de la Columna Vertebral/patologíaRESUMEN
The presence of bone and fat in the orbit provide high contrast with normal structures on both CT and MR images. In patients with visual deficits or oculomotor paralysis, imaging studies should include the intracranial cavity to evaluate the visual pathways back to the occipital cortex and the cranial nerves within the cavernous sinuses and brainstem. Magnetic resonance images display the intracranial anatomy in exquisite detail. Fat-suppressed magnetic resonance sequences should be used in conjunction with gadolinium enhancement.
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Ojo/anatomía & histología , Imagen por Resonancia Magnética , Órbita/anatomía & histología , Tomografía Computarizada por Rayos X , Vías Visuales/anatomía & histología , Nervios Craneales/anatomía & histología , Humanos , Músculos Oculomotores/anatomía & histología , Valores de ReferenciaRESUMEN
The purpose of this report was to review the MR techniques, contrast enhancement patterns, and MR imaging findings for the spinal nerve roots. The phenomenon of contrast enhancement of the nerve roots and its relationship to disk disease and failed-back-surgery syndrome are discussed. The MR imaging findings for various inflammatory and neoplastic disorders affecting the spinal nerve roots are described and illustrated.
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Imagen por Resonancia Magnética , Raíces Nerviosas Espinales/patología , Medios de Contraste , Humanos , Desplazamiento del Disco Intervertebral/diagnóstico , Desplazamiento del Disco Intervertebral/cirugía , Imagen por Resonancia Magnética/métodos , Enfermedades de la Columna Vertebral/diagnóstico , Raíces Nerviosas Espinales/anatomía & histología , Insuficiencia del TratamientoAsunto(s)
Imagen por Resonancia Magnética , Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Adulto , Ángulo Pontocerebeloso/patología , Ángulo Pontocerebeloso/cirugía , Nervios Craneales/patología , Femenino , Humanos , Neoplasias Meníngeas/patología , Neoplasias Meníngeas/cirugía , Meningioma/patología , Meningioma/cirugíaRESUMEN
We examined 25 patients with recurrent pain after lumbar disk surgery with MRI to evaluate the usefulness of gadolinium (Gd)-enhanced fat-suppression (FS) imaging in patients with failed back surgery. Pulse sequences included T1-weighted (T1W) images, Gd-enhanced T1W images, and Gd-enhanced T1W images with FS. The addition of FS to Gd-enhanced T1W images improved visualization of enhancing scar in all cases, helped distinguish scar from recurrent herniated disk, and showed more clearly the relationship of scar to the nerve roots and thecal sac. The images also demonstrated enhancement of the facet joints and theca in 23 and 11 cases, respectively. Intradural nerve roots were more conspicuous with FS in 21 cases. The combination of unenhanced and Gd-enhanced T1W images with FS is recommended for routine examination of the postoperative back.
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Desplazamiento del Disco Intervertebral/cirugía , Vértebras Lumbares/cirugía , Imagen por Resonancia Magnética/métodos , Complicaciones Posoperatorias/diagnóstico , Tejido Adiposo/patología , Adulto , Anciano , Cicatriz/diagnóstico , Diagnóstico Diferencial , Femenino , Humanos , Desplazamiento del Disco Intervertebral/diagnóstico , Vértebras Lumbares/patología , Masculino , Persona de Mediana Edad , Síndromes de Compresión Nerviosa/diagnóstico , Síndromes de Compresión Nerviosa/cirugía , Recurrencia , Raíces Nerviosas Espinales/patologíaAsunto(s)
Tumor Carcinoide/patología , Tumor Carcinoide/secundario , Neoplasias de la Columna Vertebral/secundario , Neoplasias del Timo/patología , Tumor Carcinoide/diagnóstico , Vértebras Cervicales , Humanos , Vértebras Lumbares , Metástasis Linfática , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Neoplasias de la Columna Vertebral/diagnóstico , Neoplasias del Timo/diagnóstico , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVE: Although fast spin-echo images and slower spin-echo images have similar contrast characteristics, the two techniques have not yet been shown to be equivalent in all aspects of brain imaging. To determine if the two sequences are equivalent, we compared detection of white matter lesions, image quality, and artifact degradation on fast spin-echo and spin-echo proton density-weighted and T2-weighted MR images of the brain in prospectively selected patients who were seropositive for HIV. SUBJECTS AND METHODS: Fast spin-echo and spin-echo MR images of the brain were obtained in 153 consecutive subjects. The images were reviewed independently by three experienced neuroradiologists. The size, number, and location of white matter lesions were compared for the two techniques. Image quality, motion artifact, CSF flow artifact, and gray-white matter differentiation were graded on a five-point scale. RESULTS: No statistical difference was found in gray-white matter differentiation. Overall image quality, CSF flow artifacts, and motion artifacts were slightly worse on the fast spin-echo images (p < .05). Although some variability existed in the detection of lesions less than 5 mm in diameter, the differences was small, and all larger lesions were detected by both techniques. Agreement between fast spin-echo and conventional spin-echo techniques was nearly exact with respect to characterizing findings in brain as either normal or abnormal. CONCLUSIONS: Fast spin-echo and spin-echo MR of the brain produce images of similar quality and show white matter lesions equally well. These results support the replacement of slower, conventional spin-echo pulse sequences with faster fast spin-echo sequences.
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Complejo SIDA Demencia/diagnóstico , Artefactos , Encéfalo/patología , Imagen por Resonancia Magnética/métodos , Complejo SIDA Demencia/epidemiología , Adulto , Humanos , Masculino , Persona de Mediana Edad , Estudios ProspectivosRESUMEN
PURPOSE: To describe the flow patterns in a model of the vertebrobasilar artery and use these observations to explain the appearance of the flow on the MR images. METHODS: We created an anatomically precise, transparent elastic model of the human vertebrobasilar artery containing a basilar tip aneurysm and perfused the model with non-Newtonian fluid which has similar rheologic properties to blood. Flow patterns in the vessels were directly observed. MR angiogram images were obtained with commercially available two-dimensional time-of-flight, three-dimensional time-of-flight, and 3-D phase-contrast MR angiographic pulse sequences, and they were correlated with the directly seen flow patterns. Quantitative flow velocity measurements were performed with 2-D cine phase-contrast MR angiography and correlated with the flow measured with an electromagnetic flow meter. RESULTS: Visualization studies showed the dye stream patterns in the vertebrobasilar arteries to be extremely complex and variable. During the MR experiments we found that often the same segment of a vessel could appear very different depending on the pulse sequence. In some instances, the model experiments helped to explain the MR appearance of the vessels. Flow profiles measured with 2-D cine phase contrast were found to be consistent with those measured directly with an electromagnetic flow meter. CONCLUSION: Clear elastic models can be used to duplicate the flow in human cranial vessels and thus provide a unique means to observe these flow patterns directly. The flow patterns helped to explain the variation in appearance of the vessels and the artifacts with different MR angiography pulse sequences. The artifacts depend on both the geometry of the vessel and the flow pattern within it. Two-dimensional cine phase-contrast MR provides temporal flow field information that is directly related to physiological information about flow volumes and velocity patterns.
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Arteria Basilar/fisiología , Imagen por Resonancia Magnética , Modelos Cardiovasculares , Arteria Vertebral/fisiología , Adulto , Aneurisma/patología , Aneurisma/fisiopatología , Artefactos , Arteria Basilar/anatomía & histología , Velocidad del Flujo Sanguíneo/fisiología , Arterias Cerebrales/fisiología , Colorantes , Diseño de Equipo , Hemorreología , Humanos , Aumento de la Imagen , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética/métodos , Cemento de Policarboxilato , Polisacáridos Bacterianos , Flujo Pulsátil/fisiología , Flujo Sanguíneo Regional/fisiología , Siliconas , Cloruro de Sodio , Arteria Vertebral/anatomía & histología , Grabación de Cinta de VideoRESUMEN
A number of new techniques have been developed to enhance MR imaging of the spine. Fat-suppression techniques used in conjunction with gadolinium-based contrast material improve visualization of enhancing inflammatory and neoplastic diseases. Fast spin-echo (FSE) sequences can be used to decrease imaging times, to increase resolution, or to improve signal-to-noise ratios on T2-weighted images. In general, FSE images provide a better myelographic effect with reduced magnetic susceptibility compared with gradient-recalled echo (GRE) techniques. With volume GRE sequences, thin contiguous sections can be obtained, and images can be reformatted into multiple planes from a single data set. High-contrast imaging can be accomplished by using three-dimensional (3D) turbo-fast low-angle shot (FLASH) or magnetization prepared rapid acquisition gradient-echo (MP RAGE) techniques with gadolinium contrast enhancement. Finally, CSF flow dynamics within the subarachnoid space and within cystic lesions can be elucidated with phase-contrast techniques. Judicious selection of these methods and other innovative MR techniques is necessary to maximize the potential of MR in diagnosis of spinal disease.
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Imagen por Resonancia Magnética/métodos , Enfermedades de la Columna Vertebral/diagnóstico , Columna Vertebral/patología , Medios de Contraste , Femenino , Gadolinio , Humanos , Aumento de la Imagen/métodos , Procesamiento de Imagen Asistido por Computador , MasculinoRESUMEN
Surface-coil MR imaging of the spine is one of the most commonly performed MR imaging procedures. As the spine is the region of interest in these studies, extraspinal abnormalities may be overlooked. Such lesions can be difficult to perceive because they are out of the area of interest or distant from the surface coil. MR studies may be interpreted without other radiographic studies for comparison, as the other studies often have been performed elsewhere. Consequently, it is important for radiologists to be aware of the extraspinal anatomy and the appearances of extraspinal abnormalities. We describe the appearances of some common extraspinal diseases and normal variants detected with surface-coil MR imaging of the spine.
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Imagen por Resonancia Magnética , Columna Vertebral/patología , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
PURPOSE: To determine the benefit of fat suppression in conjunction with gadolinium enhancement for evaluating neoplastic and inflammatory diseases of the spine. METHODS: Contrast-enhanced T1-weighted images were compared with the corresponding contrast-enhanced T1-weighted images with fat suppression in 14 patients with various neoplastic and inflammatory spine diseases. RESULTS: Contrast-enhanced T1-weighted images with fat suppression showed enhancing lesions in all cases of vertebral disease (five cases), but in one case some metastases did not enhance. Paravertebral (nine lesions), epidural (seven lesions), and intradural-extramedullary (six lesions) were delineated better with contrast-enhanced fat suppression. In the 14 cases (29 lesions), nine lesions were seen only on contrast-enhanced images with fat suppression. Integrity of the vertebral end plates was assessed more accurately on fat-suppressed images. CONCLUSION: Although noncontrast T1-weighted images are sufficient to screen for vertebral disease, contrast-enhanced images with fat suppression may detect additional lesions. Fat suppression should be used in conjunction with gadolinium for evaluating epidural, paravertebral, and intradural-extramedullary spinal lesions.
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Imagen por Resonancia Magnética/métodos , Enfermedades de la Columna Vertebral/diagnóstico , Tejido Adiposo , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Gadolinio , Humanos , Aumento de la Imagen/métodos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Neoplasias de la Columna Vertebral/diagnóstico , Espondilitis/diagnósticoRESUMEN
MR examination of the spine after injection of gadopentetate dimeglumine showed enhancement of the cauda equina in a case of Guillain-Barré syndrome. These MR observations may help confirm the diagnosis of Guillain-Barré syndrome.
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Imagen por Resonancia Magnética , Polirradiculoneuropatía/diagnóstico , Columna Vertebral/patología , Cauda Equina/patología , Preescolar , Femenino , Humanos , Examen Neurológico , Raíces Nerviosas Espinales/patologíaRESUMEN
OBJECTIVE: Psychosis is an uncommon but serious complication of infection with HIV. This article presents the results of a study of HIV-infected individuals with psychosis. METHOD: The authors evaluated 20 HIV-infected men who had noniatrogenic new-onset psychosis without delirium, current substance abuse, or previous psychotic episodes. Clinical, neuropsychological, CSF, magnetic resonance imaging, and neuropathologic assessments were made. A comparison group consisting of 20 nonpsychotic HIV-infected men matched to the psychotic subjects with respect to age, race, years of education, and Centers for Disease Control HIV stage was also evaluated. RESULTS: The psychotic patients differed from the nonpsychotic comparison subjects in having significantly higher rates of past stimulant and sedative/hypnotic abuse or dependence and, at follow-up, a significantly higher rate of mortality. They also showed a trend toward greater global neuropsychological impairment. CONCLUSIONS: New-onset psychosis may be, at least in part, a manifestation of an HIV-associated encephalopathy.