RESUMEN
OBJECTIVES: Multiple sclerosis (MS) is a complicated disease which occurs due to relationship between genes and environmental factors that causes tissue damage by autoimmune mechanisms.We investigated and illustrated the hypotheses correlated to the evidence of several putative environmental risk factors for MS onset and progression in this part of Iran. MATERIALS AND METHODS: Univariate logistic regression was used to detect the effects of environmental factors on the risk of MS. Data were analyzed using SPSS version 16. RESULTS: The childhood history of patients with rubella, measles and chickenpox increased the risk of MS significantly. Moreover, low consumption of dairy products, avoidance of seafood consumption, cigarette smoking and exposure to tobacco smoke, stress, anxiety disorders, depress and disturbing thoughts, negative and disturbing thoughts, developing a sudden shock upon hearing bad news, having obsessive-compulsive and being depressed increased the risk of MS significantly. CONCLUSIONS: The results of the current research partially solved the puzzling question of complex interplay between environmental factors and MS disease in this part of Iran. Incorporating these factors enables more powerful and accurate detection of novel risk factors with diagnostic and prognostic methods.
Asunto(s)
Varicela/inmunología , Interacción Gen-Ambiente , Sarampión/inmunología , Esclerosis Múltiple/inmunología , Rubéola (Sarampión Alemán)/inmunología , Adolescente , Adulto , Ansiedad/fisiopatología , Autoinmunidad , Estudios de Casos y Controles , Varicela/complicaciones , Varicela/genética , Varicela/virología , Depresión/fisiopatología , Conducta Alimentaria/psicología , Femenino , Humanos , Irán/epidemiología , Modelos Logísticos , Masculino , Sarampión/complicaciones , Sarampión/genética , Sarampión/virología , Persona de Mediana Edad , Esclerosis Múltiple/complicaciones , Esclerosis Múltiple/genética , Esclerosis Múltiple/virología , Recurrencia , Factores de Riesgo , Rubéola (Sarampión Alemán)/complicaciones , Rubéola (Sarampión Alemán)/genética , Rubéola (Sarampión Alemán)/virología , Fumar/fisiopatología , Estrés Psicológico/fisiopatologíaRESUMEN
AIM: Multiple sclerosis is a demyeliting autoimmune inflammatory disorder of central nervous system (CNS) with unknown etiology, which afflicts more than 2.5 millions of the world's population. The aim of this study was to investigate the association between some immunological-related risk factors (tonsillectomy, appendectomy and hepatitis B vaccination) and multiple sclerosis in 2014 in Hamadan city, west of Iran. METHODS: As a case-control study, data of filled questionnaire with written consents from 250 patients and 250 age and sex matched controls, were collected and analyzed using SPSS version 16 software and Logistic regression test. RESULTS: In both groups, the case and the control, with average age of 33 years, 70% of the participants were women. Statistical analysis showed that there was no significant association between tonsillectomy and appendectomy with the multiple sclerosis (p > 0.05). Also hepatitis B vaccination did not increase the risk of MS significantly (p > 0.05), although there was a trend toward more vaccination rate in the patients. CONCLUSION: Considering previous global investigations on this topic with the result of our study, it seems more studies are needed to determine the definitive association between tonsillectomy, appendectomy and hepatitis B vaccination with multiple sclerosis.
