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1.
Sci Prog ; 106(4): 368504231205985, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37844880

RESUMEN

This study investigated the differences in programming novices' intrinsic motivation and performance within a Scratch-based programming learning environment using a pretest-posttest intervention design. Specifically, this study aimed to examine what and how achievement emotions were aroused to impact learners' academic success during Scratch implementation processes by employing regression analyses. One hundred and seventy-two undergraduates (Mage = 20.44, SDage = 1.09, 55.8% female) were voluntarily recruited to participate in a Scratch-based instruction workshop during a 6-week period. The workshop was structured with regard to preparation, Scratch-based programming learning and projects, and assessment activities and questionnaire implemented both before the instructional period and after the workshop. The results suggested that the Scratch-based intervention significantly increased students' overall motivation and examination performance. Concerning achievement emotions, the outcome emotion of hopelessness first negatively predicted students' motivation and performance. Anxiety then replaced hopelessness as a negative predictor, while enjoyment was the strongest predictor of motives and performance. Taking eight emotions together, the arousal of activity and outcome emotions within visual programming environments facilitated students' emotion dynamics that impacted motivation and performance. The discussion and contributions concerning the mechanism behind the effectiveness of visualization and the emotion-performance relationship are presented herein.


Asunto(s)
Aprendizaje , Motivación , Humanos , Femenino , Masculino , Logro , Emociones , Estudiantes/psicología
2.
Front Public Health ; 10: 1005252, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36684977

RESUMEN

Background: Although early dementia detection is crucial to optimize the treatment outcomes and the management of associated symptoms, the published literature is scarce regarding the effectiveness of active screening protocols in enhancing dementia awareness and increasing the rate of early detection. The present study compared the detection ratio of an active community-based survey for dementia detection with the detection ratio of passive screening during routine clinical practice. Data for passive screening were obtained from the National Health Insurance (NHI) system, which was prospectively collected during the period from 2000 to 2003. Design: A population-based cohort study with historical control. Setting: Taiwan. Participants: A total of 183 participants aged 65 years or older were involved in a community-based survey. Data from 1,921,308 subjects aged 65 years or older were retrieved from the NHI system. Measurements: An adjusted detection ratio, defined as a ratio of dementia prevalence to incidence was used. Results: The results showed that the dementia prevalence during the 2000-2003 period was 2.91% in the elderly population, compared with a prevalence of 6.59% when the active survey was conducted. The incidence of dementia in the active survey cohort was 1.83%. Overall, the dementia detection ratio was higher using active surveys [4.23, 95% confidence interval (CI): 2.68-6.69] than using passive detection (1.45, 95% CI: 1.43-1.47) for those aged 65-79 years. Similar findings were observed for those aged 80 years and older. Conclusion: The implementation of an active community-based survey led to a 3-fold increase in the detection rate of early dementia detection compared to passive screening during routine practice.


Asunto(s)
Demencia , Humanos , Anciano , Estudios de Cohortes , Taiwán/epidemiología , Encuestas y Cuestionarios , Incidencia , Demencia/diagnóstico , Demencia/epidemiología
3.
Acta Neurol Taiwan ; 30(2): 74-77, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34549392

RESUMEN

PURPOSE: Paraneoplastic neurological disorders associated with autoantibodies are rare diseases, causing abnormal manifestations in the central or peripheral nervous system separately or simultaneously. Early recognizing the occurrence of paraneoplastic syndrome can lead to prompt and effective management. CASE REPORT: We presented a patient of subacute cerebellar degeneration with cachectic and bed-ridden status, who was proven to have positive SOX1 antibody. A coexisting Lambert-Eaton myasthenic syndrome was also documented by electrophysiological study. CONCLUSION: Intensive and regular follow up for an occult malignancy is crucial in patients with SOX1 antibody. Coadministration of therapies for underlying malignancy and LEMS improve the functional disability.


Asunto(s)
Enfermedades Cerebelosas , Síndrome Miasténico de Lambert-Eaton , Neoplasias Pulmonares , Síndromes Paraneoplásicos , Humanos , Síndrome Miasténico de Lambert-Eaton/complicaciones , Síndrome Miasténico de Lambert-Eaton/diagnóstico , Degeneración Nerviosa , Síndromes Paraneoplásicos/etiología
4.
J Clin Monit Comput ; 32(3): 519-525, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28466203

RESUMEN

Sedative anesthetic procedures outside the operating room may depend on cylinders as oxygen source. Cylinders have limited storage capacity and a low oxygen flow rate improves the durability. We conducted the bench study to evaluate the fraction of inspired oxygen (FiO2) in different oxygen entrainment devices under low oxygen flow rate. The purpose of the bench study was to provide information to choose appropriate oxygen entrainment devices in non-operating room sedative anesthetic procedures. We utilized a manikin head-test lung-ventilator model and evaluated eight oxygen entrainment devices, including four nasal cannulas, two oral bite blocks, and two masks. Two different minute volumes that defined as the normal ventilation and the hypoventilation group were evaluated. Three pneuflow resistors were placed in turn in the mouth represented ratio of the nasal/oral breathing. Each condition was sampled 70 times after a 3 min ventilation period. Most devices had few drop in FiO2 according to the increased oral breathing ratio in normal ventilation. Most devices had obvious drop in FiO2 related to the increased oral breathing ratio in hypoventilation. Oxygen reservoir units had little effect for accumulating oxygen in normal ventilation. In the hypoventilation group, oxygen reservoir units helped oxygen retention in local area and maintained a higher oxygen concentration. There were multiple factors lead to different oxygen fraction that we measured, such as different devices, respiratory patterns, and oxygen reservoir units. The result of our bench study provided some information for anesthesiologist to choose appropriate oxygen entrainment devices in various sedative anesthetic procedures.


Asunto(s)
Anestesia/métodos , Cánula , Pulmón , Terapia por Inhalación de Oxígeno/instrumentación , Terapia por Inhalación de Oxígeno/métodos , Oxígeno/química , Respiración , Anestésicos , Humanos , Máscaras , Quirófanos , Pruebas de Función Respiratoria , Fenómenos Fisiológicos Respiratorios , Ventiladores Mecánicos
5.
J Clin Monit Comput ; 30(2): 169-73, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25895481

RESUMEN

Esophagogastroduodenoscopy procedures are typically performed under conscious sedation. Drug-induced respiratory depression is a major cause of serious adverse effects during sedation. Capnographic monitoring of respiratory activity improves patient safety during procedural sedation. This bench study compares the performance of the nasal cannulas and oral bite blocks used to monitor exhaled CO2 during sedation. We used a spontaneously breathing mechanical lung to evaluated four CO2 sampling nasal cannulas and three CO2 sampling bite blocks. We placed pneumatic resistors in the mouth of the manikin to simulate different levels of mouth opening. We compared CO2 measurements taken from the sampling device to CO2 measurements taken directly from the trachea. The end tidal CO2 concentration (PETCO2) measured through the bite blocks and nasal cannulas was always lower than the corresponding PETCO2 measured at the trachea. The difference became larger as the amount of oxygen delivered through the devices increased. The difference was larger during normal ventilation than during hypoventilation. The difference became larger as the amount of oral breathing increased. The two nasal cannulas without oral cups failed to provide sufficient CO2 for breath detection when the mouth was fully open and oxygen was delivered at 10 L/min. Our simulation found that respiratory rate can be accurately monitored during the procedure using a CO2 sampling bite block or a nasal cannula with oral cup. The accuracy of PETCO2 measurements depends on the device used, the amount of supplement oxygen, the amount of oral breathing and the patient's minute ventilation.


Asunto(s)
Cánula , Capnografía/instrumentación , Dióxido de Carbono/análisis , Sedación Consciente/instrumentación , Endoscopía del Sistema Digestivo/instrumentación , Monitoreo Intraoperatorio/instrumentación , Humanos , Monitoreo Fisiológico/instrumentación , Cavidad Nasal
6.
Opt Express ; 22(22): 27169-74, 2014 Nov 03.
Artículo en Inglés | MEDLINE | ID: mdl-25401867

RESUMEN

We report on the enhancement of photoluminescence and laser action behaviors of ZnO submicron spheres fabricated by a sol-gel process. As annealing temperature increases, intense ultraviolet excitonic emission at room temperature can be observed. Upon pulsed excitations, the lasing threshold gradually decreases as annealed temperature increases, which is consistent with the results of the ratio of surface-trapped exciton to donor-bound exciton emissions at low temperature. X-ray photoelectron spectroscopy confirmed that adsorbed OH bonds played a critical role in trapping species of exciton at the ZnO surface. The superior optical properties of high-annealing ZnO mainly result from the elimination of a surface-trapped state.

7.
J Clin Neurosci ; 20(4): 604-6, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23298881

RESUMEN

A patient with typical Lambert-Eaton myasthenic syndrome (LEMS) has a clinical manifestation of proximal muscle weaknesses, a larger-than-100% incremental change in repetitive nerve stimulation on high-rate stimulation electrophysiological testing, and a paraneoplastic origin from small cell carcinoma of the lung. Here, we present a patient with an atypical myasthenic syndrome with an oculobulbar-predominant muscle involvement, a borderline incremental change in repetitive nerve stimulation at high frequencies, and a paraneoplastic origin from extrapulmonary mixed small cell carcinoma and adenocarcinoma. The purpose of this report is to emphasize the importance of painstaking scrutiny in the examination of a patient with a less-common presentation of LEMS.


Asunto(s)
Adenocarcinoma/complicaciones , Carcinoma de Células Pequeñas/complicaciones , Síndrome Miasténico de Lambert-Eaton/complicaciones , Adenocarcinoma/patología , Anciano , Dióxido de Carbono/metabolismo , Carcinoma de Células Pequeñas/patología , Estimulación Eléctrica , Humanos , Síndrome Miasténico de Lambert-Eaton/patología , Ganglios Linfáticos/diagnóstico por imagen , Ganglios Linfáticos/patología , Masculino , Debilidad Muscular/etiología , Examen Neurológico , Síndromes Paraneoplásicos/patología , Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos X
8.
Opt Express ; 19 Suppl 3: A219-24, 2011 May 09.
Artículo en Inglés | MEDLINE | ID: mdl-21643363

RESUMEN

Omnidirectional and broadband light harvesting is critical to photovoltaics due to the sun's movement and its wide spectral range of radiation. In this work, we demonstrate distinctive indium-tin-oxide nanowhiskers that achieve superior angular and spectral characteristics for crystalline silicon solar cells using angle-resolved reflectance spectroscopy. The solar-spectrum weighted reflectance is well below 6% for incident angles of up to 70° and for the wavelength range between 400nm and 1000nm. As a result, the nanowhisker coated solar cell exhibits broadband quantum efficiency characteristics and enhanced short-circuit currents for large angles of incidence.

9.
Nanotechnology ; 22(9): 095201, 2011 Mar 04.
Artículo en Inglés | MEDLINE | ID: mdl-21258142

RESUMEN

As silicon photovoltaics evolve towards thin-wafer technologies, efficient optical absorption for the near-infrared wavelengths has become particularly challenging. In this work, we present a solution that employs combined micro- and nano-scale surface textures to increase light harvesting in the near-infrared for crystalline silicon photovoltaics, and discuss the associated antireflection and scattering mechanisms. The surface textures are achieved by uniformly depositing a layer of indium-tin-oxide nanowhiskers on micro-grooved silicon substrates using electron-beam evaporation. The nanowhiskers facilitate optical transmission in the near-infrared by functioning as impedance matching layers with effective refractive indices gradually varying from 1 to 1.3. Materials with such unique refractive index characteristics are not readily available in nature. As a result, the solar cell with combined textures achieves over 90% external quantum efficiencies for a broad wavelength range of 460-980 nm, which is crucial to the development of advanced thin-substrate silicon solar cells.


Asunto(s)
Suministros de Energía Eléctrica , Nanoestructuras/química , Nanoestructuras/efectos de la radiación , Nanotecnología/instrumentación , Silicio/química , Energía Solar , Cristalización/métodos , Diseño de Equipo , Análisis de Falla de Equipo , Rayos Infrarrojos , Luz , Ensayo de Materiales , Propiedades de Superficie
10.
Neurologist ; 16(3): 206-7, 2010 May.
Artículo en Inglés | MEDLINE | ID: mdl-20445433

RESUMEN

BACKGROUND: Hypoglycemia is a frequently encountered cause of altered mental status in clinical practice. OBJECTIVES: To report a rare case with hypoglycemia-induced coma as the sole and initial clinical manifestation of a hepatic tumor. CASE REPORT: A previously healthy 32-year-old man presenting with acute change in consciousness was found to have hepatoma related hypoglycemia. CONCLUSION: This case highlights the importance of a hepatic evaluation in, otherwise, unexplained hypoglycemic coma in high prevalence areas of hepatocellular carcinoma such as the Asian-Pacific region.


Asunto(s)
Encefalopatías Metabólicas/etiología , Encefalopatías Metabólicas/fisiopatología , Carcinoma Hepatocelular/complicaciones , Hipoglucemia/etiología , Hipoglucemia/fisiopatología , Neoplasias Hepáticas/complicaciones , Adulto , Pueblo Asiatico , Biomarcadores de Tumor/análisis , Glucemia/metabolismo , Encéfalo/metabolismo , Encéfalo/fisiopatología , Carcinoma Hepatocelular/diagnóstico por imagen , Carcinoma Hepatocelular/virología , Glucosa/uso terapéutico , Hepatitis B/complicaciones , Hepatitis B/etnología , Humanos , Neoplasias Hepáticas/diagnóstico por imagen , Neoplasias Hepáticas/virología , Masculino , Pronóstico , Taiwán/epidemiología , Taiwán/etnología , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
11.
Am J Phys Med Rehabil ; 89(8): 668-71, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19966559

RESUMEN

Friction massage is a commonly used physical therapy that is usually safe and without complication. We report an unusual case of posterior interosseous nerve palsy that arose after friction massage. Electrophysiologic findings confirmed a focal neuropathy 4-6 cm distal to the lateral epicondyle. The neurologic symptoms resolved completely 2 mos after discontinuation of friction massage. This case experience broadens the spectrum of etiologies of posterior interosseous nerve palsy. Nerve conduction studies may be a useful adjunct to a thorough physical examination to confirm the diagnosis and is important to prognostic evaluation, if unexplained neurologic symptoms develop after certain physical therapy procedures. Further treatment includes avoiding compression and observation.


Asunto(s)
Masaje/efectos adversos , Neuropatía Radial/etiología , Codo de Tenista/rehabilitación , Adulto , Electromiografía , Femenino , Humanos , Masaje/métodos , Conducción Nerviosa
12.
Appl Opt ; 48(35): 6606-20, 2009 Dec 10.
Artículo en Inglés | MEDLINE | ID: mdl-20011000

RESUMEN

Wafer identifications (wafer ID) can be used to identify wafers from each other so that wafer processing can be traced easily. Wafer ID recognition is one of the problems of optical character recognition. The process to recognize wafer IDs is similar to that used in recognizing car license-plate characters. However, due to some unique characteristics, such as the irregular space between two characters and the unsuccessive strokes of wafer ID, it will not get a good result to recognize wafer ID by directly utilizing the approaches used in car license-plate character recognition. Wafer ID scratches are engraved by a laser scribe almost along the following four fixed directions: horizontal, vertical, plus 45 degrees , and minus 45 degrees orientations. The closer to the center line of a wafer ID scratch, the higher the gray level will be. These and other characteristics increase the difficulty to recognize the wafer ID. In this paper a wafer ID recognition scheme based on an asterisk-shape filter and a high-low score comparison method is proposed to cope with the serious influence of uneven luminance and make recognition more efficiently. Our proposed approach consists of some processing stages. Especially in the final recognition stage, a template-matching method combined with stroke analysis is used as a recognizing scheme. This is because wafer IDs are composed of Semiconductor Equipment and Materials International (SEMI) standard Arabic numbers and English alphabets, and thus the template ID images are easy to obtain. Furthermore, compared with the approach that requires prior training, such as a support vector machine, which often needs a large amount of training image samples, no prior training is required for our approach. The testing results show that our proposed scheme can efficiently and correctly segment out and recognize the wafer ID with high performance.

13.
Neuroepidemiology ; 33(4): 344-9, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19887841

RESUMEN

AIMS/HYPOTHESIS: To investigate the prevalence and correlates of somatic and autonomic neuropathies concurrently in prediabetic and diabetic subjects in the general population. SUBJECTS AND METHODS: Nerve conduction and heart rate variability studies were used for detecting both types of diabetic neuropathy. Of 1,576 inhabitants, 143 persons were identified as prediabetic or having diabetic mellitus. One hundred and thirty-three persons completed a nerve conduction test and 118 persons a valid heart rate variability test. Significant correlates responsible for diabetic neuropathies were also collected. RESULTS: The prevalence rates of definite, probable and no somatic neuropathy were 9.0% (12/133), 20.3% (27/133) and 70.7% (94/133), respectively. The corresponding figures for autonomic neuropathy were 14.4% (17/118), 54.2% (64/118) and 31.4% (37/118). The prevalence rate for the presence of both neuropathies was 16.9%. In a univariate analysis, age, renal insufficiency, HbA1c and fasting glucose level were significantly associated with somatic neuropathy whereas only systolic blood pressure was statistically significantly associated with autonomic neuropathy. In a multivariate analysis, systolic blood pressure and fasting glucose level were positively associated with somatic neuropathy and systolic blood pressure remained statistically significant for autonomic neuropathy. CONCLUSIONS: The prevalence of autonomic neuropathy is twofold compared with somatic neuropathy. Concurrence of the two kinds of neuropathy was approximately half of sole somatic neuropathy and a quarter of sole autonomic neuropathy. Systolic blood pressure and fasting glucose level were related to somatic neuropathy whereas only systolic blood pressure was correlated with autonomic neuropathy.


Asunto(s)
Diabetes Mellitus Tipo 2/epidemiología , Neuropatías Diabéticas/epidemiología , Estado Prediabético/epidemiología , Anciano , Arritmias Cardíacas/epidemiología , Comorbilidad , Neuropatías Diabéticas/diagnóstico , Electrocardiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Conducción Nerviosa , Prevalencia , Factores de Riesgo , Taiwán/epidemiología
14.
J Nanosci Nanotechnol ; 7(1): 374-80, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17455507

RESUMEN

We have investigated the optothermal property and decomposition characteristics of PtO(x) ultrathin film protected by ZnS-SiO2 layers and effects of the constituent phases of PtO(x) on super-resolution capability and read stability of the super-RENS disk. All the ZnS-SiO2/PtO(x)/ZnS-SiO2 multilayers exhibited a steep reflectivity drop at the temperature range between 265 and 350 degrees C, corresponding to the decomposition of PtO(x). The decomposition temperature of the 4-nm-thick PtO(x) ultrathin film protected by ZnS-SiO2 layers was much lower than those obtained in thick PtO(x) films without protection. The activation energy for thermal decomposition was approximately 1.3 eV. Both the decomposition temperature and activation energy for thermal decomposition were unaffected by the constituent phases of PtO(x). Carrier to noise ratios (CNR) of over 40 dB for mark size of 150 nm were achieved in all super-resolution near-field structure (super-RENS) disks, while the super-resolution readout was limited to 2.5 x 10(3) approximately 4.5 x 10(4) cycles. The effect of constituent phases of PtO(x) on the super-resolution capability of super-RENS disk with a PtO(x) mask layer was minimal. However, as the constituent phases of PtO(x) mask layer transformed from a mixture of Pt and PtO, to pure PtO, and then to a mixture of PtO and PtO2, the readout stability of super-RENS disk increased dramatically since less heat was absorbed by the PtO(x) mask layer composed of PtO and PtO2 during the readout process, prohibiting the diffusion of materials inside the bubble to the GeSbTe phase change layer.


Asunto(s)
Equipos de Almacenamiento de Computador , Almacenamiento y Recuperación de la Información , Nanotecnología/métodos , Óxidos/química , Platino (Metal)/química , Dióxido de Silicio/química , Sulfuros/química , Compuestos de Zinc/química , Electroquímica/métodos , Calor , Microscopía Electrónica de Rastreo , Óptica y Fotónica , Temperatura , Difracción de Rayos X
15.
Eur J Nucl Med Mol Imaging ; 34(9): 1458-66, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17437108

RESUMEN

PURPOSE: The purpose of this study was to further localize cerebral perfusion abnormalities, and to better correlate these abnormalities with the clinical severity of Parkinson's disease (PD). METHODS: A single-photon emission computed tomography (SPECT) study was performed on 27 patients with PD and 24 age-matched controls. SPECT images were spatially normalized, concatenated, and then decomposed using Infomax independent component analysis (ICA). The resulting image components were separated by logistic regression into two subspaces: "disease-related" components whose subject weights differed between groups, and "disease-unrelated" components. The resultant regional cerebral blood flow (rCBF) subspace images were normalized to global CBF for each subject, and then processed using statistical parametric mapping to compare rCBF values between PD and control subjects. RESULTS: In the disease-related image subspace, patients with PD exhibited significantly higher adjusted rCBF in the putamen, globus pallidum, thalamus, brainstem, and the anterior lobe of the cerebellum, and significant hypoperfusion in the parieto-temporo-occipital cortex, the dorsolateral prefrontal cortex, the insula, and the cingulate gyrus. The motor Unified Parkinson's Disease Rating Scale scores correlated negatively with rCBF in the insula and cingulate gyrus. In the disease-unrelated image subspace, no brain voxels exhibited a significant group difference. CONCLUSION: ICA-based separation of normalized images into disease-related and disease-unrelated subspaces revealed many disease-related group blood flow differences. The regions revealed by ICA are consistent with the current model of PD. These rCBF changes in PD have not been fully demonstrated in any single functional imaging study previously.


Asunto(s)
Circulación Cerebrovascular , Enfermedades Neurodegenerativas/diagnóstico , Enfermedades Neurodegenerativas/patología , Enfermedad de Parkinson/diagnóstico , Enfermedad de Parkinson/patología , Tomografía Computarizada de Emisión de Fotón Único/métodos , Anciano , Femenino , Giro del Cíngulo/patología , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Masculino , Persona de Mediana Edad , Modelos Estadísticos , Enfermedades Neurodegenerativas/sangre , Enfermedad de Parkinson/sangre , Análisis de Componente Principal , Flujo Sanguíneo Regional
16.
Neuroepidemiology ; 28(1): 50-5, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17215587

RESUMEN

This study sought to determine the sensitivity of sural sensory action amplitude (SAP) and peroneal motor conduction velocity (MCV) for differentiating the status of other nerve conduction velocities and identifying important correlates of diabetic polyneuropathy. Subjects (n = 708) with type 2 diabetes from one community completed a preliminary questionnaire. Among the 298 subjects with positive questionnaire results, 272 completed nerve conduction tests. The means of 6 nerve conduction velocities of subjects with both SAP and MCV abnormalities were compared to those of normal controls. The mean conduction velocities of all motor and sensory nerves were slower (p < 0.05) in subjects with polyneuropathy than without polyneuropathy. Important known correlates of diabetic polyneuropathy can also be identified by this electrophysiological definition. The sural SAP and peroneal MCV together serve as a good diagnostic for diabetic polyneuropathy and can be used as a simplified criterion in field studies.


Asunto(s)
Potenciales de Acción/fisiología , Neuropatías Diabéticas/diagnóstico , Electrodiagnóstico/métodos , Conducción Nerviosa/fisiología , Nervio Peroneo/fisiopatología , Nervio Sural/fisiopatología , Adulto , Anciano , Neuropatías Diabéticas/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tiempo de Reacción/fisiología , Sensibilidad y Especificidad
17.
J Formos Med Assoc ; 105(6): 503-7, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16801039

RESUMEN

Paralysis periodica paramyotonica is an overlapping disease that shares the features of paramyotonia characteristic of paramyotonia congenita (PC) and periodic paralysis characteristic of hyperkalemic periodic paralysis. We report the case of a 23-year-old man with paralysis periodica paramyotonica. His father and a younger brother also exhibited a similar phenotype. A SCN4A Arg1448Cys mutation was detected in this family. The affected family members exhibited marked shifts in compound muscle action potential amplitudes on exercise test, and muscle weakness could be induced by potassium loading and cold exposure. This case demonstrates that SCN4A Arg1448Cys can produce paralysis periodica paramyotonica. Other genetic or environmental factors may modulate the manifestation of SCN4A Arg1448Cys mutation.


Asunto(s)
Miotonía Congénita/genética , Parálisis Periódica Hiperpotasémica/genética , Canales de Sodio/genética , Adulto , Humanos , Masculino , Mutación , Canal de Sodio Activado por Voltaje NAV1.4 , Linaje
20.
Appl Opt ; 44(15): 3001-5, 2005 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-15929290

RESUMEN

We present a study in which we enhance the carrier-to-noise ratio of a superresolution near-field structure (super-RENS) disk to read below 100-nm marks by implementing a mask layer comprising a Au nanocluster-embedded dielectric film. Various Au nanocluster-embedded mask layers are fabricated by a radio-frequency cosputtering process, and the size and distribution of Au nanoclusters are controlled. To verify the enhancement of the various films for super-RENS disk applications, the sensitivity enhancement of plasmonic gas sensing is demonstrated.

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