BACKGROUND: Cyprodinil is a widely used fungicide with broad-spectrum activity, but it has been associated with cardiac abnormalities. (-)-Epicatechin gallate (ECG), a natural polyphenolic compound, has been shown to possess protective properties in cardiac development. METHODS: In this study, we investigated whether ECG could mitigate cyprodinil-induced heart defects using zebrafish embryos as a model. Zebrafish embryos were exposed to cyprodinil with or without ECG. RESULTS: Our results demonstrated that ECG significantly improved the survival rate, embryo movement, and hatching delay induced by cyprodinil. Furthermore, ECG effectively ameliorated cyprodinil-induced cardiac developmental toxicity, including pericardial anomaly and impairment of cardiac function. Mechanistically, ECG attenuated the cyprodinil-induced alterations in mRNA expression related to cardiac development, such as amhc, vmhc, tbx5, and gata4, as well as calcium ion channels, such as ncx1h, atp2a2a, and cdh2. Additionally, ECG was found to inhibit the activity of the aryl hydrocarbon receptor (AhR) signaling pathways induced by cyprodinil. CONCLUSIONS: In conclusion, our findings provide evidence for the protective effects of ECG against cyprodinil-induced cardiac developmental toxicity, mediated through the inhibition of AhR activity. These findings contribute to a better understanding of the regulatory mechanisms and safe utilization of pesticide, such as cyprodinil.
Catechin , Heart , Receptors, Aryl Hydrocarbon , Zebrafish , Animals , Receptors, Aryl Hydrocarbon/metabolism , Heart/drug effects , Catechin/analogs & derivatives , Catechin/pharmacology , Heart Defects, Congenital/metabolism , Embryo, Nonmammalian/drug effects , Embryo, Nonmammalian/metabolism , Signal Transduction/drug effects , Fungicides, Industrial/pharmacology , Gene Expression Regulation, Developmental/drug effects
OBJECTIVE: The OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings. METHODS: We analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword "supraventricular tachycardia." Trade names and generic names were obtained by querying the RxNav database, and the proportions were summarized. The proportionate reporting ratio (PRR), reporting odds ratio, and chi-square values were also summarized. We created Asahi diagrams and set the screening criteria to drug events ≥30, PRR >2, and chi-square >4. Outcomes were evaluated using the Side Effect Resource database, several scientific literature databases, and the Hangzhou Yiyao Rational Medication System. RESULTS: A total of 2435 distinct medications were found to induce SVT between the first quarter of 2004 and 2023, leading to 22,375 documented adverse events related to SVT. Further investigation revealed that salbutamol, paroxetine, formoterol, paclitaxel, venlafaxine, and theophylline were most likely to cause SVT. CONCLUSION: We conducted signal mining of adverse drug events using the OpenVigil database and evaluated the six drugs most likely to cause SVT. The results of this research can serve as a drug safety reference in the clinic.
Drug-Related Side Effects and Adverse Reactions , Tachycardia, Supraventricular , Humans , Tachycardia, Supraventricular/drug therapy , Tachycardia, Supraventricular/epidemiology , Albuterol , Databases, Factual , Formoterol Fumarate
The monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio (monocyte-to-HDL-C ratio) was proposed as a marker of atherosclerosis. Osteoporosis and atherosclerosis share common risk factors and pathophysiological mechanisms. This study aimed to assess the relationship between monocyte-to-HDL-C ratio and osteoporosis. Participants aged ≥50 years with complete bone mineral density (BMD), monocyte, and HDL-C examination data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were included. Descriptive analysis was performed separately according to males and females. Weight linear regression and weight logistic regression analyses were used to analyze the association between the monocyte-to-HDL-C ratio and BMD and osteopenia and osteoporosis and vertebral fracture. A total of 1804 participants were included. Among the participants with osteopenia, 398 (48.31%) were males and 466 (51.91%) were females. Among those with osteoporosis, 38 (2.77%) were males and 95 (9.50%) were females. In females, monocyte-to-HDL-C ratio was negatively associated with femoral neck BMD (regression coefficient (ß) = -0.18; 95% confidence interval (CI): (-0.29, -0.07)) and high monocyte-to-HDL-C ratio was associated with higher odds of osteopenia (odds ratio (OR) = 1.22; 95% CI: (1.01, 1.47)) and osteoporosis (OR = 1.68; 95% CI: (1.13, 2.49)) after adjusting for confounders. In males, only monocyte-to-HDL-C ratio >0.35 was observed to be associated with higher odds of osteoporosis (OR = 1.96; 95% CI: (1.02, 3.79)). Stratified analyses showed that similar results were also found in different populations. This study showed that the monocyte-to-HDL-C ratio was negatively associated with BMD and the risk of osteopenia and osteoporosis in females. The monocyte-to-HDL-C ratio may be a new marker of osteoporosis or osteopenia.
Atherosclerosis , Bone Diseases, Metabolic , Osteoporosis , Male , Female , Humans , Nutrition Surveys , Cholesterol, HDL , Monocytes , Osteoporosis/complications , Bone Density , Bone Diseases, Metabolic/epidemiology , Bone Diseases, Metabolic/complications , Bone Diseases, Metabolic/diagnosis , Atherosclerosis/complications
ABSTRACT Teenagers are the future of our country, and their physical health has a great impact on the economic and social development of our country. In view of this, this study applied questionnaire survey, analytic hierarchy and situation analysis to construct the evaluation index system and hierarchical structure model of youth physical health promotion path, and used empirical analysis to analyze and deal with the key factors in the index system. The results show that the coordinates are (0.648, 0.648, 0.648, 654) located in the first quadrant, which indicates that the external opportunities and internal advantages have a high degree of matching; the effect of youth physical health management under the government mechanism is poor, but youth physical health management under the market mechanism needs to be established. The internal advantages of youth physical health management are relatively large, and the public management service market has great potential, and the market-oriented health construction. It is hoped that this study can provide certain reference for the improvement of Chinese teenagers' physical health.
RESUMO Os adolescentes são o futuro do nosso país, e sua saúde física tem grande impacto no desenvolvimento econômico e social do nosso país. Em vista disso, este estudo aplicou o método de levantamento por questionário, processo de hierarquia analítica e método de análise situacional para construir o sistema de índice de avaliação e modelo de estrutura hierárquica do caminho da melhora da saúde física entre os jovens, e usou o método de análise empírica para analisar e tratar os fatores-chave do sistema de índice. Os resultados mostram que as coordenadas estão (0.648, 0.648, 0.648, 0.648, 654) localizadas no primeiro quadrante, o que indica que as oportunidades externas e as vantagens internas têm um alto grau de correspondência; o efeito da gestão da saúde física dos jovens no âmbito do mecanismo governamental é precária, mas a gestão da saúde física dos jovens no âmbito do mecanismo de mercado precisa de ser estabelecida. As vantagens internas da gestão da saúde física dos jovens são relativamente grandes, e o mercado de serviços de gestão pública tem um grande potencial, além da saúde orientada para o mercado. Espera-se que este estudo possa fornecer alguma referência para a melhoria da saúde física dos adolescentes chineses.
RESUMEN Los adolescentes son el futuro de nuestro país y su salud física tiene un gran impacto en el desarrollo económico y social de nuestro país. En vista de esto, este estudio aplicó encuestas de cuestionario, procesos de jerarquía analítica y análisis de situación para construir el sistema de índices de evaluación y el modelo de estructura jerárquica del camino de promoción de la salud física de los jóvenes, y utilizó análisis empíricos para tratar los factores clave en el sistema de índices. Los resultados muestran que las coordenadas están (0.648, 0.648, 0.648, 654) ubicadas en el primer cuadrante, lo que indica que las oportunidades externas y las ventajas internas tienen un alto grado de coincidencia. El efecto de la gestión de la salud física de los jóvenes bajo el mecanismo del gobierno es pobre, es necesario establecer la gestión de la salud física de los jóvenes bajo el mecanismo del mercado. Las ventajas internas de la gestión de la salud física de los jóvenes son relativamente grandes y el servicio de gestión pública del mercado tiene un gran potencial. Por eso es necesaria la construcción de la salud orientada al mercado. Se espera que este estudio pueda proporcionar una referencia para la mejora de la salud física de los adolescentes chinos.
Humans , Adolescent , Sports , Health Status , Public Sector , Health Promotion , China
