RESUMEN
The last few years has seen a rapid growth in life sciences in Scotland, in terms of scientific achievement, business development and expansion of core research facilities and infrastructure. The dramatic increase in investment, both internal and external, underlines the increasing recognition and strength of Scotland's academic research base. This editorial seeks to illustrate this from a personalised medicine perspective, with examples of major initiatives in Scotland in component disciplines such as pharmacogenomics, stem cell science, bioinformatics and systems biology. The scientific advances being made in these and other areas will inevitably result in the identification of new or improved applications of personalised therapies.
RESUMEN
Chromium carbene-mediated Dötz benzannulation has been shown to proceed remarkably rapidly and with enhanced efficiency under developed microwave-assisted conditions.
RESUMEN
A series of mono- and per-6-substituted cyclodextrin derivatives were synthesized as synthetic receptors (or host molecules) of rocuronium bromide, the most widely used neuromuscular blocker in anaesthesia. By forming host-guest complexes with rocuronium, these cyclodextrin derivatives reverse the muscle relaxation induced by rocuronium in vitro and in vivo and therefore can be used as reversal agents of the neuromuscular blocker to assist rapid recovery of patients after surgery. Because this supramolecular mechanism of action does not involve direct interaction with the cholinergic system, the reversal by these compounds, e.g., compound 14 (Org 25969), is not accompanied by cardiovascular side effects usually attendant with acetylcholinesterase inhibitors such as neostigmine. The structure-activity relationships are consistent with this supramolecular mechanism of action and are discussed herein. These include the effects of binding cavity size and hydrophobic and electrostatic interaction on the reversal activities of these compounds.