The Young Age and Plant-Based Diet Hypothesis for Low SARS-CoV-2 Infection and COVID-19 Pandemic in Sub-Saharan Africa.

Since the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease-19 (COVID-19), in December 2019, the infection has spread around the globe. Some of the risk factors include social distancing, mask wearing, hand washing with soap, obesity, diabetes, hypertension, asthma, cardiovascular disease, and dysbiosis. Evidence has shown the incidence of total infection and death rates to be lower in sub-Saharan Africa when compared with North Africa, Europe and North America and many other parts of the world. The higher the metabolic syndrome rate, the higher the risk of SARS-CoV-2 infection. Africa has a lower rate of metabolic syndrome risk than many other continents. This paradox has puzzled several in the biomedical and scientific communities. Published results of research have demonstrated the exciting correlation that the combination of young age of the population coupled with their native plant-based diet has lowered their risk factors. The plant-based diet include whole grains (millet, sorghum), legumes (black-eye peas, dry beans, soybean), vegetables, potato, sweet potato, yams, squash, banana, pumpkin seeds, and moringa leaves, and lower consumption of meat. The plant-based diet results in a different gut microbiota than of most of the rest of the world. This has a significant impact on the survival rate of other populations. The "plant-based diet" results in lower rates of obesity, diabetes and dysbiosis, which could contribute to lower and less severe infections. However, these hypotheses need to be supported by more clinical and biostatistics data.

Correlates of HIV testing among men from the Democratic Republic of Congo: an analysis of the 2014 Demographic Health Survey.

Human immunodeficiency virus (HIV) testing is a cornerstone in preventing HIV infections and accessing treatment for HIV. However, HIV testing remains low among men in the Democratic Republic of Congo (DRC). The purpose of this study was to assess the correlates of HIV testing among men in the DRC. Data from the 2014 DRC Demographic Health Survey were analyzed to assess the relationships between HIV testing and the correlates of HIV testing among 7830 men aged 15-59 years. Although more than half (4763 or 63.7%) knew of an HIV testing site, only one-sixth (1187 or 16.6%) reported ever being tested for HIV. The multivariate logistic regression indicated that men aged between 25 and 34 years were more likely to have tested for HIV than those aged between 15 and 24 years (aOR = 1.70; 95% CI: [1.23-2.34]). In addition, men with college experience were 5.47 more likely to have tested for HIV than men with no formal education (aOR = 5.47; 95% CI: [2.53-11.84]). The results highlight the need for a national HIV testing awareness and uptake campaign for Congolese men to increase HIV testing among this group and prevent HIV infections.

Use of Insecticide-Treated Mosquito Net among Pregnant Women and Guardians of Children under Five in the Democratic Republic of the Congo.

BACKGROUND: Insecticide-treated mosquito nets (ITNs) are one of the most effective tools for preventing malaria in sub-Saharan Africa. OBJECTIVE: This study examined knowledge, attitude, and practice on the use of ITNs in the prevention of malaria among pregnant women and guardians of children under five in the Democratic Republic of the Congo. METHODS: A total of 5,138 pregnant women and guardians of children under five were interviewed. RESULTS: The majority of participants (>80%) knew the signs and symptoms of malaria; 81.6% reported having an ITN in the household, but 78.4% reported using it the night before the interview. Only 71.4% of pregnant women used ITN the night compared to 68.2% of children under five. In the Logistic Regression model, women who believed that it is normal to use ITNs were 1.9 times more likely to use it than those who did not (OR: 1.930); women who were confident in their abilities to use ITNs were 1.9 times more likely than those who were not confident (OR: 1.915); and women who had a good attitude towards ITNs were also more likely to use ITNs compared to those who did not (OR: 1.529). CONCLUSION: New and innovative evidence-based behavior change interventions are needed to increase the utilization of ITNs among vulnerable groups.

FACTORS ASSOCIATED WITH THE UPTAKE OF SODIUM DICHLOROISOCYANURATE (NADCC) TABLETS AS HOUSEHOLD WATER-TREATMENT PRODUCT AMONG CAREGIVERS OF CHILDREN UNDER FIVE IN BENIN, WEST AFRICA.

Improving access to safe drinking water is a critical step in mitigating diarrheal diseases that affect millions of children under 5 years throughout the developing world each year. While the delivery of safe water is out of the reach of many countries, the utilization of Sodium dichloroisocyanurate (NaDCC) is a proven cost-effective alternative to prevent diarrhea caused by waterborne pathogens. However, its uptake remains low in many developing countries, such as the Republic of Benin. This study examines the trends and the determinants of NaDCC uptake in Benin. Population Services International and its affiliate conducted two multistage household surveys among caregivers of children under five in Benin to examine the practices towards diarrheal disease in children under five and identify the factors associated with the use of NaDCC in this population. 2912 respondents/caregivers of children under five were interviewed in 2009 versus 3196 in 2011. The proportion of caregivers who reported ever treating water with NaDCC increased from 5.8% in 2009 to 11.5% in 2011, p < 0.001. The logistic regression model showed that caregivers who knew places that sell NaDCC in the community; those who felt capable of utilizing NADCC correctly to treat drinking water as well as caregivers who reported to be Muslim were more likely than their counterparts to use NaDCC as water treatment product. In order to increase the use of NADCC among caregivers, the Government of Benin and its development partners should focus not only on making NADCC available in the community and informing the community members about the different points of sale, but also in building up the capacity and confidence of caregivers in utilizing it.

Pregnancy and other factors associated with higher CD4+ T-cell counts at HIV diagnosis in Southeast Michigan, 1992-2002.

BACKGROUND: Early diagnosis of HIV infection provides the opportunity for treatment to prevent progression to AIDS and for intervention to prevent further transmission. The impact of routine screening of pregnant women and other factors on the stage of HIV disease at diagnosis were evaluated. METHODS: Data were collected in 1992-2002 from the medical records of persons presenting for HIV-related care at 2 major medical centers in Detroit, Michigan. Patients were included in the analysis if they had a CD4+ T-cell count recorded within 6 months of their first positive HIV test (N = 1858). RESULTS: Half of the patients (49%) had a first CD4+ T-cell count of < 200 cells/mm3 and 19% had an AIDS-defining illness at the time of HIV diagnosis. In the multivariate model, pregnant women were less likely than nonpregnant women to enter care with a CD4+ T-cell count of < 200 cells/mm3 (odds ratio, .24; 95% confidence interval, .14-.41). Even after adjusting for pregnancy, female sex was protective, as was age < 30 years. HIV-transmission risk factors, race, and time period of HIV diagnosis were not significantly associated with first CD4+ T-cell counts of < 200 cells/mm3. CONCLUSION: Routinely offering HIV testing in prenatal care, as required by Michigan law, resulted in earlier diagnoses of HIV in pregnant women, as indicated by their higher CD4+ T-cell counts. Increasing routine HIV testing of all persons seeking medical care may increase the overall proportion of HIV diagnoses that are made early in the disease process.

Shift in the reasons why adults seek HIV testing in the United States: policy implications.

HIV testing is an important step in the continuum of HIV care. It provides the opportunity to counsel people who seek testing and links those who test positive to health services. To determine the number of adults who had ever been tested for HIV, compare the reasons they sought testing, and evaluate the policy implications of their decision, data from the 1998 and 2002 National Health Interview Surveys were analyzed. Of 31,138 adults interviewed in 1998, 9728 (31.2%) reported they had been tested for HIV, whereas 10,760 (34.7%) of the 31,044 adults interviewed in 2002 had been tested for HIV. Persons who were interviewed in 1998 and 2002 were similar with regard to sociodemographic characteristics (age, gender, ethnicity, education, and region of origin). The reasons for seeking HIV testing changed between 1998 and 2002. The proportion of adults who were tested for HIV "to find out if infected or not" declined significantly, from 33.9% in 1998 to 11.8% in 2002 (P < .05); the proportion of those who were tested because the HIV test was "part of a routine medical checkup or surgical procedure" increased from 11.4% to 24.6% (P < .05). During the same period, the proportion of adults who ever were tested for HIV because the test was required for health/life insurance, immigration, or military induction decreased slightly, from 14.9% to 14.4%. The increase in testing overall may be explained, in part, by the growing acceptance of routine HIV testing among adults in the United States. While mandatory HIV testing remains controversial, it accounted for 13% to 15% of adults who became aware of their HIV serostatus in 1998 and 2002. This contribution raises questions about its merit in the fight against HIV infection.

African American women: a life course of care?

Twenty-five years of research on family care to dependent elders has produced a theoretically sophisticated understanding of the process of family caregiving. Although caregiving models initially were developed and tested on predominantly White samples, more recent work has applied these models to African American caregivers. This investigation builds on the comparative perspective by describing elder care in African American families through the eyes of the culture in which it occurs. Thirty-two African American caregivers were interviewed and asked to discuss their caregiving careers from a life course perspective. Qualitative narratives described three pathways to care: elder care only, limited life course of care, and live course of care. Recognition of the various pathways to care will enlighten tailored interventions.

Potential barriers to seeking human immunodeficiency virus testing among adults in the United States: data from the 1998 National Health Interview Survey.

To assess potential barriers to seeking human immunodeficiency virus (HIV) testing among adults in the United States, data from the 1998 National Health Interview Survey (NHIS) were analyzed. The NHIS is a multistage cluster survey of the United States noninstitutionalized civilian population ages 18 years or older. The 1998 NHIS survey was conducted using the computer-assisted personal interview. Of a nationally representative sample (n = 32,440) of the U.S. noninstitutionalized civilian population, 21,410 (66%) have never been tested for HIV, 9,728 (30%) have been tested, and 1302 (4%) did not complete the survey or refused to answer the question. Among individuals who completed the survey, men (odds ratio [OR]: 1.08, 95% confidence interval [CI] = 1.04, 1,22), individuals ages 50 years or older (OR: 4.01, 95% CI = 3.16, 5.08), or 18-19 years (OR: 2.12, 95% CI = 1.71, 2.63), those who had "up to 11 grade" level of education (OR: 2.16, 95% CI = 1.74, 2.63), those who lived in nonmetropolitan areas (OR: 1.21, 95% CI = 1.14, 1.28), or lived in the Midwest (1.34, 95% CI = 1.24, 1.43) were significantly more likely than their counterparts to have not sought HIV testing. Among individuals who have never been tested for HIV, 58% had no particular reason, 38% felt they were not at risk of contracting HIV, whereas less than 1% feared adverse consequences. The high proportion of adults who never tested for HIV after two decades of HIV epidemic underscores the need for new approaches to fight the spread of HIV infection in the United States.